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Cytokines, hematopoiesis, osteoclastogenesis, and estrogens

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References

  1. Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the proliferation of hemopoietic cells in-vitro. J Cell Physiol 91:335–344

    Google Scholar 

  2. Whitlock CA, Witte ON (1982) Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci USA 79:3608–3612

    Google Scholar 

  3. Namen AE, Schiemer AE, March CJ, Overell RW, Park LS, Urdal DL, Mochizuki DL (1988) B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J of Exp Med 167:988–1002

    Google Scholar 

  4. Heard JM, Fichelson S, Varet B (1982) Role of colony-stimulating activity in murine long-term bone marrow cultures: evidence for its production and consumption by the adherent cells. Blood 59:761

    Google Scholar 

  5. Gualtieri RJ, Shadduck RK, Baker DG, Quesenberry PJ (1982) Hematopoietic regulatory factors produced in long-term murine bone marrow cultures and the effect of in-vitro irradiation. Blood 59:761

    Google Scholar 

  6. Gualtieri RJ, Yang G, Shadduck RK, Waheed A, Banks J (1987) Identification of the hematopoietic growth factors elaborated by bone marrow stromal cells using antibody neutralization analysis. Exp Hematol 15:883

    Google Scholar 

  7. Boswell HS, Mochizuki DY, Burgess GS, Gillis S, Walker EB, Williams DE (1990) A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with IL-3 and IL-4. Exp Hematol 18:794–800

    Google Scholar 

  8. Kurihara N, Suda T, Miura Y, Nakauchi H, Kodama H, Hiura K, Hakeda Y, Kumegawa M (1989) Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 74:1295–1302

    Google Scholar 

  9. Kahn AJ, Simmons DJ (1975) Investigation of the cell lineage in bone using a chimera of chick and quail embryonic tissue. Nature 258:325

    Google Scholar 

  10. Scheven BAA, Visser JWM, Nijweide PJ (1986) In-vitro osteoclast generation from different bone marrow fractions, including a highly enriched hematopoietic stem cell population. Nature 321:79

    Google Scholar 

  11. Kurihara N, Civin C, Roodman GD (1991) Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype. J Bone Miner Res 6:257–261

    Google Scholar 

  12. Hattersley G, Kerby JA, Chambers TJ (1991) Identification of osteoclast precursors in multilineage hemopoietic colonies. Endocrinology 128:259–262

    Google Scholar 

  13. Owen M (1985) Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed) Bone and mineral research, vol 3. Elsevier, Amsterdam, pp 1–24

    Google Scholar 

  14. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T (1988) Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600–2602

    Google Scholar 

  15. McSheehy PMJ, Chambers TJ (1986) Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118:824–828

    Google Scholar 

  16. McSheehy PM, Chambers TJ (1987) 1,25-dihydroxyvitamin D3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J Clin Invest 80:425–429

    Google Scholar 

  17. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T (1989) The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805–1813

    Google Scholar 

  18. Hattersley G, Chambers TJ (1989) Generation of osteoclasts from hemopoietic cells and a multipotential cell line in-vitro. J Cell Physiol 140:478–482

    Google Scholar 

  19. Boyce BF, Aufdemorte TB, Garrett IR, Yates AJP, Mundy GR (1989) Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 125:1142–1150

    Google Scholar 

  20. Johnson RA, Boyce BF, Mundy GR, Roodman GD (1989) Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice. Endocrinology 124:1424–1427

    Google Scholar 

  21. Gowen M, Wood D, Ihrie EJ, McGuire KB, Russell RG (1983) An interleukin-1-like factor stimulates bone resorption in-vitro. Nature 306:378–380

    Google Scholar 

  22. Bertolini DR, Nedwin GE, Bringman TS (1986) Stimulation of bone resorption and inhibition of bone formation in-vitro by human tumour necrosis factors. Nature 319:516–518

    Google Scholar 

  23. Pfeilschifter J, Chenu C, Bird A, Mundy GR, Roodman GD (1989) Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in-vitro. J Bone Miner Res 4:113–118

    Google Scholar 

  24. Horowitz MC, Coleman DL, Flood PM, Kupper TS, Jilka RL (1989) Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest 83:149–157

    Google Scholar 

  25. Horowitz MC, Einhorn TA, Philbrick W, Jilka RL (1989) Functional and molecular changes in colony stimulating factor secretion by osteoblasts. J Connect Tissue Res 20:159–168

    Google Scholar 

  26. MacDonald BR, Mundy GR, Clark S, Wang EA, Kuehl TJ, Stanley ER, Roodman GD (1986) Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures. J Bone Miner Res 1:227–233

    Google Scholar 

  27. Hattersley G, Chambers TJ (1990) Effects of interleukin-3 and of granulocyte-macrophage and macrophage colony-stimulating factors on osteoclast differentiation from mouse hemopoietic tissue. J Cell Physiol 142:201–209

    Google Scholar 

  28. Lee MY, Fukunaga R, Lee TJ, Lottsfeldt JL, Nagata S (1991) Bone modulation in sustained hematopoietic stimulation in mice. Blood 77:2135–2141

    Google Scholar 

  29. Thomson BM, Saklatvala J, Chambers TJ (1986) Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. J Exp Med 164:104–112

    Google Scholar 

  30. Thompson BM, Mundy GR, Chambers TJ (1987) Tumor necrosis factors α and β induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunol 138:775

    Google Scholar 

  31. Kishimoto T (1989) The biology of interleukin-6. Blood 74(1):1–10

    Google Scholar 

  32. Michalevicz R, Lifshitz D, Revel M (1989) Interferon-β 2/interleukin-6 and interleukin-3 synergize in stimulating proliferation of human early hematopoietic progenitor cells. Scanning Microsc 3:1143–1150

    Google Scholar 

  33. Lowik CWGM, van der Pluijm G, Bloys H, Hoekman K, Bijvoet OLM, Aarden LA, Papapoulos SE (1989) Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Comm 62, No. 3:1546–1552

    Google Scholar 

  34. Ishimi Y, Miyaura C, He Jin C, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297–3303

    Google Scholar 

  35. Al-Humidan A, Ralston SH, Hughes DE, Chapman K, Aarden L, Russell RGG, Gowen M (1991) Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae. J Bone Miner Res 6:3–8

    Google Scholar 

  36. Garrett IR, Black KS, Mundy GR (1990) Interactions between interleukin-6 and interleukin-1 in osteoclastic bone resorption in neontal mouse calvariae (abstract). Calcif Tissue Int 46 (suppl 2):A37

    Google Scholar 

  37. Black K, Garrett IR, Mundy GR (1991) Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 128:2657–2659

    Google Scholar 

  38. Feyen JHM, Elford P, DiPadova FE, Trechsel U (1989) Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 4:633–638

    Google Scholar 

  39. Girasole G, Sakagami Y, Hustmyer FG, Yu X, Derrigs HG, Boswell S, Peacock M, Boder G, Manolagas SC (1990) 17β-estradiol inhibits cytokine-induced IL-6 production by bone marrow stromal cells and osteoblasts (abstract 795). J Bone Miner Res 5 (suppl 2)

  40. Klein B, Zhang XG, Jourdan M, Content J, Houssiau F, Aarden L, Piechaczyk M, Bataille R (1989) Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73:517–526

    Google Scholar 

  41. Agematsu K, Takeuchi S, Ichikawa M, Yabuhara A, Uehara Y, Kawai H, Miyagawa Y, Ishii K, Katsuyama T, Nakahata T, Komiyama A (1991) Spontaneous production of interleukin-6 by KI-1-position large-cell anaplastic lymphoma with extensive bone destruction. Blood 77:2299–2303

    Google Scholar 

  42. Abe E, Ishimi Y, Takahashi N, Akatsu T, Ozawa H, Yamana H, Yoshiki S, Suda T (1988) A differentiation-inducing factor produced by the osteoblastic cell line MC3T3-E1 stimulates bone resorption by promoting osteoclast formation. J Bone Miner Res 3:635

    Google Scholar 

  43. Shiina-Ishimi Y, Abe E, Tanaka H, Suda T (1986) Synthesis of colony-stimulating factor (CSF) and differentiation-inducing factor (D-factor) by osteoblastic cells, clone MC3T3-E1. Biochem Biophys Res Commun 134:400

    Google Scholar 

  44. Metcalf D, Gearing DP, (1990) Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc Natl Acad Sci USA 86:5948–5952

    Google Scholar 

  45. Leary AG, Wong GG, Clark SC, Smith AG, Ogawa M (1990) Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hemapoietic stem cells. Blood 75:1960–1964

    Google Scholar 

  46. Allan EH, Hilton DJ, Brown MA, Evely RS, Yumita S, Metcalf D, Gough NM, Ng KW, Nicola NA, Martin TJ (1990) Osteoblasts display receptors for and response to leukemia-inhibitory factor. J Cell Physiol 145:110–119

    Google Scholar 

  47. Noda M, Vogel RL, Hasson DM, Rodan GA (1990) Leukemia inhibitory factor suppresses proliferation, alkaline phosphatase activity, and type I collagen messenger ribonucleic acid level and enhances osteopontin mRNA level in murine osteoblast-like (MC3T3E1) cells. Endocrinology 127:185–190

    Google Scholar 

  48. Kodama H, Yamasaki A, Nose M, Niida S, Ohgame Y, Abe M, Kumegawa M, Suda T (1991) Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. 173:269–272

    Google Scholar 

  49. Umezawa A, Tachibana K, Harigaya K, Kusakari S, Kato S, Watanabe Y, Takano T (1991) Colony-stimulating factor 1 expression is down-regulated during the adipocyte differentiation of H-1/A marrow stromal cells and induced by cachectin/tumor necrosis factor. Mol Cell Biol 11:920–927

    Google Scholar 

  50. Crandall TL, Joyce RA, Boggs DR (1980) Estrogens and hematopoiesis: characterization and studies on the mechanism of neutropenia. J Lab Clin Med 95:857–867

    Google Scholar 

  51. Gaunt SD, Pierce KR (1985) Myelopoiesis and marrow adherent cells in estradiol-treated mice. Vet Pathol 22:403–408

    Google Scholar 

  52. Liu C-C, Howard GA (1991) Bone-cell changes in estrogen-induced bone-mass increase in mice: dissociation of osteoclasts from bone surfaces. Anat Rec 229:240–250

    Google Scholar 

  53. Pacifici R, Brown C, Puscheck E, Friedrich E, Slatopolsky E, Maggio D, McCracken R, Avioli LV (1991) Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA 88:5134–5138

    Google Scholar 

  54. Tabibzadeh SS, Santhanam U, Sehgal PB, May LT (1989) Cytokine-induced production of 202-1 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17β. J Immunol 142:3134–3139

    Google Scholar 

  55. Passeri G, Girasole G, Markus T, Abrams JS, Manolagas SC, Jilka RL (1991) 17β-estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures (abstract 716). J Bone Miner Res 6:S263

    Google Scholar 

  56. Girasole G, Paul D, Passeri G, Herring J, Jilka RL, Manolagas SC, Williams DC (1991) Increased osteoclast-like cell formation from bone marrow aspirates and trabecular bone loss are induced by ovariectomy and reversed by estrogen replacement in the mouse (abstract 859). J Bone Miner Res 6:S299

    Google Scholar 

  57. Kalu DN (1990) Proliferation of tartrate-resistant acid phosphatase-positive multinucleate cells in ovariectomized animals. Soc Exp Biol Med 195:70–74

    Google Scholar 

  58. Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314:1676

    Google Scholar 

  59. Riggs BL, Jowsey J, Kelly PJ, Jones JD, Maher FT (1969) Effect of sex hormones on bone in primary osteoporosis. J Clin Invest 48:1065–1072

    Google Scholar 

  60. Frost HM (1966) Bone dynamics in osteoporosis and osteomalacia. Springfield, Springfield IL, pp 1–176

  61. Frost HM (1981) Osteoporosis: quo vadis? Orthop Clin North Am 12:683–691

    Google Scholar 

  62. Frost HM (1973) Bone remodeling and its relation to metabolic bone disease. Springfield, Springfield IL, pp 1–210

  63. Witsell AL, Schook LB (1991) Macrophage heterogeneity occurs through a developmental mechanism. Proc Natl Acad Sci USA 88:1963–1967

    Google Scholar 

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Manolagas, S.C., Jilka, R.L. Cytokines, hematopoiesis, osteoclastogenesis, and estrogens. Calcif Tissue Int 50, 199–202 (1992). https://doi.org/10.1007/BF00296282

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