Abstract
This trial aimed to test if the half life of radioiodinated heptadecanoic acid (HDA) in acutely infarcted myocardium is of prognostic value. Twenty patients had an HDA scan and a MUGA scan within 6 days of acute myocardial infarction, eighteen of these had a visible defect on the HDA images. The mean half life of the areas of acute infarction (15.50 min+/-7.82 min) was significantly shorter than that of normal myocardium (20.77 min+/-4.00 min). The MUGA scan was repeated after 6 months in 15 patients. The mean acute infarct half life was longer in patients with an LVEF improvement of at least 5% at 6 months (16.92 min+/-10.56 min), compared to those with a deterioration of more than 5% (11.75 min+/-4.03 min), although the difference is not statistically significant. While the results in a few individuals suggested that the half life may be of prognostic significance, the variable response of the group reduced the ability of the half live to act as a prognostic indicator. Improvements in imaging and background subtraction techniques may be necessary before the half life is of practical value.
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Stoddart, P.G.P., Papouchado, M. & Wilde, P. Prognostic value of 123-IODO-heptadecanoic acid imaging in patients with acute myocardial infarction. Eur J Nucl Med 12, 525–528 (1987). https://doi.org/10.1007/BF00296090
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DOI: https://doi.org/10.1007/BF00296090