Skip to main content
SpringerLink
Log in

AB0 incompatibility and its interaction with haptoglobins and placental alkaline phosphatase

  • Original Investigations
  • Published:
Humangenetik Aims and scope Submit manuscript

Summary

In a sample of 25 population groups, correlation coefficients were calculated between the proportion of AB0 blood-group incompatibility as well as the gene frequencies and haptoglobin and placental alkaline-phosphatase phenotypes and genotypes, separately. Correlation coefficients were also calculated between haptoglobin and placental alkaline phosphatase. A significant positive correlation was found between AB0 incompatibility and the PlF-gene frequency. There was a positive correlation between the Hp1-gene frequency and the 0 blood group, though no significant correlations were found between the proportion incompatibility and the Hp1-gene frequency. The results are discussed.

Zusammenfassung

An einer Stichprobe von 25 Populationen wurden die Korrelationen zwischen dem Anteil der AB0-Blutgruppen-Unverträglichkeit sowie den Genfrequenzen und den Phänotypen- und Genotypenfrequenzen der Haptoglobine und der placentaren alkalischen Phosphatasen bestimmt. Ebenso wurden die Korrelationskoeffizienten zwischen den Haptoglobin-und alkalischen Placentaphosphatasen-Genfrequenzen ermittelt. Eine signifikant positive Korrelation ergab sich für die Beziehung zwischen der AB0-Unverträglichkeit und der PlF-Frequenz. Weiterhin ergab sich eine positive Korrelation zwischen der Hp1-Frequenz und der 0-Blutgruppenfrequenz, obwohl zwischen dem Anteil der Blutgruppenunverträglichkeit und der Hp1-Frequenz keine signifikante Korrelation vorlag. Die Ergebnisse werden diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Allen, G. V., Scott McGregor, R. G.: Emergency blood transfusion in Singapore. Med. J. Malaya 2, 136–147 (1947)

    Google Scholar 

  • Ananthakrishnan, R., Beck, W., Walter, H., Arndt-Hanser, A., Gumbel, W., Leithoff, H., Wigand, R., Zimmermann, W. v. Boros, B.: A mother-child combination analysis for AB0-Hp interaction. Humangenetik 18, 203–206 (1973)

    Google Scholar 

  • Anderson, J. M.: Nature's transplant, pp. 1–139. London: Butterworths 1972

    Google Scholar 

  • Baitsch, H., Liebrich, K. G., Pinkerton, E. J., Mermod, L. E.: Zur Populationsgenetik der Haptoglobin-Serumgruppen. Allelenhäufigkeit in Europa und Ozeanien. Acta Genet. med. (Roma) 11, 308–313 (1962)

    Google Scholar 

  • Beck, W.: Verteilungs- und korrelationsstatistische Untersuchungen zur alkalischen Plazentaphosphatase. Diplom-Arbeit, pp 1–41, Universität Mainz

  • Beckman, G.: Placental alkaline phosphatase, relation between phenotype and enzyme activity. Hum. Hered. 20, 74–80 (1970)

    Google Scholar 

  • Beckman, G., Beckman, L.: Relation between AB0 blood groups and the level of placental alkaline phosphatase in sera of pregnant women. Hum. Hered. 20, 187–192 (1970)

    Google Scholar 

  • Beckman, G., Johannsson, E. O.: Distribution of placental alkaline phosphatase types in the Icelandic population. Acta genet. (Basel) 17, 413–417 (1967)

    Google Scholar 

  • Beckman, L.: Blood groups and serum alkaline phosphatase. Series Haematologica I, 137–152 (1968)

    Google Scholar 

  • Beckman, L., Beckman, G., Christodoulou, C., Ifekwunigwe, A.: Variations in human placental alkaline phosphatase. Acta genet. (Basel) 17, 406–412 (1967)

    Google Scholar 

  • Beckman, L., Grivea, M.: Haptoglobin variations in newborn children. Acta genet. (Basel) 14, 159–167 (1964)

    Google Scholar 

  • Beckman, L., Johannsson, E. O.: Haptoglobins and transferrins in the Icelandic population. 17, 341–344 (1967)

    Google Scholar 

  • Beer, A. E., Billingham, R. E.: Immunobiology of mammalian reproduction. In: Advances in immunology, Dickson, F. J., Kunkel, H. E., Eds., Vol. 14, p. 84. New York-London: Academic Press 1971

    Google Scholar 

  • Blake, N. M., Kirk, R. L., Bonham, D. G.: Placental alkaline phosphatase types in Maoris and Polynesian Islanders. N. Z. J. Med. 74, 170–172 (1971)

    Google Scholar 

  • Blake, N. M., Kirk, R. L., Fliegner, J. R. H.: Placental alkaline phosphatase types in Papuans and Fijians. Med. J. Aust. 2, 342–343 (1969a)

    Google Scholar 

  • Blake, N. M., Kirk, R. L., Mehra, B.: Placental alkaline phosphatase types in Malaysia. Hum. Hered. 19, 20–24 (1969b)

    Google Scholar 

  • Blake, N. M., Kirk, R. L., Osathanondh, V.: Placental alkaline phosphatase types in Thailand. Med. J. Aust. 2, 1042–1045 (1968)

    Google Scholar 

  • Bottini, E., Lucarelli, P., Gloria, F.: Placental alkaline phosphatase and AB0 system polymorphisms: analysis of relationships among gene frequencies in human populations. Further evidence at the population level for an interaction between the two polymorphisms. Amer. J. hum. Genet. 24, 505–513 (1972b)

    Google Scholar 

  • Bottini, E., Lucarelli, B., Palmarino, R., Spennati, G. F., Reynaud, G.: Placental alkaline phosphatase polymorphism in some Italian populations. Humangenetik 11, 62–65 (1970)

    Google Scholar 

  • Bottini, E., Lucarelli, B., Pigram, P., Palmarino, R., Spennati, G. F., Orzalesi, M.: Alkaline phosphatase polymorphism of the human plancenta in people of Negro and European origins living in Connecticut. Hum. Biol. 43, 1–6, (1971)

    Google Scholar 

  • Bottini, E., Lucarelli, B., Pigram, P., Palmarino, R., Spennati, G. F., Orzalesi, M.: Interaction between placental alkaline phosphatase and AB0 system polymorphisms during intrauterine life. Amer. J. hum. Genet. 24, 495–504 (1972a)

    Google Scholar 

  • Cavalli-Sforza, L. L., Bodmer, W.: The genetics of human populations, pp. 204–208. San Francisco: Freeman 1971

    Google Scholar 

  • Cohen, B.: AB0 and Rh incompatibility. I. Foetal and neonatal mortality with AB0 and Rh incompatibility: some new interpretations. Amer. J. hum. Genet. 22, 412–439 (1970a)

    Google Scholar 

  • Cohen, B. H.: AB0 and Rh incompatibility. II. Is there a dual interaction in combined AB0 and Rh incompatibility? Amer. J. hum. Genet. 22, 441–452 (1970b)

    Google Scholar 

  • Constatoulis, N. C., Paidoussis, M.: The distribution of AB0 and Rh blood groups in Greece. Bibl. haemat. (Basel) 7, 206–211 (1958)

    Google Scholar 

  • Das, S. R., Mukherjee, B. N., Das, S. K., Blake, N. M., Kirk, R. L.: Placental alkaline phosphatase types in Calcutta. Jap. J. hum. Genet. 3, 155–158 (1970)

    Google Scholar 

  • Galatius-Jensen, F.: The haptoglobins, a genetical study, pp. 1–116. Copenhagen: Dansk Videnskabs Forlag 1960

    Google Scholar 

  • Garlick, J. P., Barnicott, N. A.: Blood groups and haemoglobin variants in Nigerian (Yoruba) school children. Ann. hum. Genet. 21, 420–425 (1957)

    Google Scholar 

  • Giblett, E. R.: Genetic markers in human blood, pp. 64–125. Oxford-Edinburgh: Blackwell 1969

    Google Scholar 

  • Grundbacher, F. J.: Effects of AB0 incompatible pregnancies and the origin of isoantibodies on mothers of infants with AB0 hemolytic disease of the newborn. Z. Immun.-Forsch. 136, 68–78 (1968)

    Google Scholar 

  • Hervey, G. W., Diamond, L. K., Watson, V.: Geographic blood group variability in the United States. J. Amer. med. Ass. 145, 80–81 (1951)

    Google Scholar 

  • Hiraizumi, Y.: Prezygotic selection as a factor in the maintenance of variability. Cold Spr. Harb. Symp. quant. Biol. XXIX, 51–60 (1964)

    Google Scholar 

  • Hiraizumi, Y., Spradlin, C. T., Ho, R., Anderson, S. A.: Birth order dependent segregation frequency in the AB0 blood groups. Amer. J. hum. Genet. 25, 277–286 (1973a)

    Google Scholar 

  • Hiraizumi, Y., Spradlin, C. T., Ho, R., Anderson, S. A.: Frequency of prenatal deaths and its relationship to the AB0 blood groups in man. Amer. J. hum. Genet. 25, 362–371 (1973b)

    Google Scholar 

  • Ishimoto, G.: Distribution of placental alkaline phosphatase types in a Japanese population. Hum. Hered. 20, 193–198 (1970)

    Google Scholar 

  • Kehr-Löke, E. R., Weyrauch, U., Ritter, H., Goedde, H. W.: Untersuchungen zur Populationsgenetik der Haptoglobin-Untergruppen. Blut 14, 97–100 (1966)

    Google Scholar 

  • Kirk, R. L.: The haptoglobin groups in man. Monographs in human genetics No. 4, Beckman, L., Hauge, M. S., Eds., pp. 1–77. Basel: Karger 1968

    Google Scholar 

  • Kirk, R. L.: Haptoglobin mating frequency, segregation and AB0 blood group interaction analysis for additional series of families. Ann. hum. Genet. 34, 329–337 (1971)

    Google Scholar 

  • Kirk, R. L., Kinns, H., Morton, N. E.: Interaction between the AB0 blood group and haptoglobin systems. Amer. J. hum. Genet. 22, 384–389 (1970)

    Google Scholar 

  • Kockwa, S., Rosenfield, R. E., Tallal, L., Wassermann, L. R.: Isoagglutinins associated with AB0 erythroblastosis. J. clin. Invest. 40, 874–883 (1961)

    Google Scholar 

  • Lechat, M. F., Bias, W. V., Blumberg, B. S., Melartin, L., Guinto, R. S., Cohen, B. H., Tolentino, J. G., Abalos, R. M.: A controlled study of polymorphisms in serum globulin and glucose-6-phosphate dehydrogenase deficiency in leprosy. Int. J. Leprosy 36, 179–189 (1968)

    Google Scholar 

  • Loke, Y. W., Ballard, A. C.: Blood group A antigens on human trophoblast cells. Nature (Lond.) 245, 329–330 (1973)

    Google Scholar 

  • Matsunaga, E.: Selektion durch Unverträglichkeit im AB0-Blutgruppen-System zwischen Mutter und Fetus. Blut II, 188–198 (1956)

    Google Scholar 

  • Matsunaga, E., Itoh, S.: Blood groups and fertility in a Japanese population, with special reference to intrauterine selection due to maternal foetal incompatibility. Ann. hum. Genet. 22, 11–131 (1958)

    Google Scholar 

  • Morton, N. E., Chung, C. S., Mi, M. P.: Genetics of interracial crosses in Hawaii. In: Monographs in human genetics No. 3, Beckman, L., Gauge, M., Eds., pp. 1–158. Basel: Karger 1967

    Google Scholar 

  • Mourant, A. E., Kopec, A. C. Domaniewska-Sobezak, K.: The AB0 blood groups, pp. 1–270. Oxford: Blackwell 1958

    Google Scholar 

  • Peritz, E.: A statistical study of the intrauterine selection factors related to the AB0 system. II. The analysis of fetal mortality data. Ann. hum. Genet. 34, 389–394 (1971)

    Google Scholar 

  • Ritter, H., Hinkelmann, K.: Zur Balance des Polymorphismus der Haptoglobine. Humangenetik 2, 21–24 (1966)

    Google Scholar 

  • Robson, E. B., Harris, H.: Genetics of the alkaline phosphatase polymorphism of the human placenta. Nature (Lond.) 207, 1257–1259 (1965)

    Google Scholar 

  • Robson, E. B., Harris, H.: Further studies on the genetics of placental alkaline phosphatase. Ann. hum. Genet. 30, 219–232 (1967)

    Google Scholar 

  • Sever, L. E.: AB0 hemolytic disease of the newborn as a selection mechanism at the AB0 locus. Amer. J. Phys. Anthrop. 31, 177–186 (1969)

    Google Scholar 

  • Shim, B., Bearn, A. G.: The distribution of haptoglobin subtypes in various populations including subtype patterns in some non-human primates. Amer. J. hum. Genet. 16, 477–483 (1964)

    Google Scholar 

  • Spennati, G. F., Pizzoferrato, A.: Ripartizione di groupe sanguigne nella popolazione del'aquila e provincia. Difesa soc. 34, 1–9 (1955)

    Google Scholar 

  • Takano, K., Miller, J. R.: AB0 incompatibility as a cause of spontaneous abortion: evidence from abortuses. J. med. Genet. 9, 144–150 (1972)

    Google Scholar 

  • Voak, D.: The pathogenesis of AB0 hemolytic disease of the newborn. Vox. Sang. (Basel) 17, 481–513 (1969)

    Google Scholar 

  • Vogel, F.: Blood groups and disease. Amer. J. hum. Genet. 22, 464–475 (1970)

    Google Scholar 

  • Vogel, F., Helmbold, W.: Blutgruppen-Populationsgenetik und Statistik. In: Human-genetik. Ein kurzes Handbuch in fünf Bänden, Becker, P. E., Ed., Bd. 1–4, pp. 129–389. Stuttgart: Thieme 1972

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anthropologisches Institut, Mainz

    R. Ananthakrishnan, W. Beck & H. Walter

Authors
  1. R. Ananthakrishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Walter
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the Deutsche Forschungsgemeinschaft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ananthakrishnan, R., Beck, W. & Walter, H. AB0 incompatibility and its interaction with haptoglobins and placental alkaline phosphatase. Humangenetik 23, 31–43 (1974). https://doi.org/10.1007/BF00295680

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00295680

Keywords

Search

Navigation