Summary
Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest.
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Warren, S.T., Glover, T.W., Davidson, R.L. et al. Linkage and recombination between fragile X-linked mental retardation and the factor IX gene. Hum Genet 69, 44–46 (1985). https://doi.org/10.1007/BF00295528
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DOI: https://doi.org/10.1007/BF00295528