Summary
One hundred and sixty-seven blood donors, 26 families with 72 offspring and 12 motherchild couples were studied for the phosphoglycolate phosphatase polymorphism. In hemolysates, the isozymes are stable for at least five weeks. The distribution of observed phenotypes in the population study did pot diverge from the expected values according to Hardy-Weinberg law. In the family study, the formal genetic model of three alleles—PGP 1, PGP 2 and PGP 3 at one autosomal locus-could be confirmed. Among 33 individuals from a Mongoloid population PGP 1 was observed in 100%. This observation lead us to the conclusion, based also on recent data in Negroid populations (Barker and Hopkinson 1978), that phosphoglycolate phosphatase may be a more recent polymorphism of Caucasoid populations. Linkage studies with the hpα locus an chromosome 16 resulted in 19 meiotic divisions of 4 informative families in a lod score peak of 0.23 at τ=0.25 being inconclusive. The inclusion of the PGP system in paternity testing is also discussed.
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References
Amorin A, Siebert G, Ritter H, Kömpf J (1980) Formal genetics of phosphoglycolate phosphatase (PGP): Investigation on 272 motherchild pairs. Hum Genet 53:419
Badwey JA (1977) Phosphoglycolate phosphatase in human erythrocytes. J Biol Chem 252:2441–2443
Barker RF, Hopkinson DA (1978) Genetic polymorphism of human phosphoglycolate phosphatase (PGP). Ann Hum Genet 42:143–151
Donald LJ, Wang HS, Hamerton JL (1980) Human phosphoglycolate phosphatase is coded by a gene on chromosome 16. Cytogenet Cell Genet 27:184–186
Golan R, Ben-Ezzer J, Szeinberg A (1981) Phosphoglycolate phosphatase in several population groups in Israel. Hum Hered 31:82–92
Martin W, Weise W, Himmelsbach B (1981) Polymorphismus der Phosphoglykolat-Phosphatase. Ärztl Lab (in press)
Ott J (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28:528
Povey S, Jeremiah SJ, Barker RF, Hopkinson DA, Robson EB, Cook PJL, Solomon E, Bobrow M, Carritt B, Buckton KE (1980) Assignment of the human locus determining phosphoglycolate phosphatase (PGP) to chromosome 16. Ann Hum Genet (London) 43:241
Richardson KE, Tolbert NE (1960) Phosphoglycolic acid phosphatase. J Biol Chem 236:1285–1290
Rittner Ch (1974) Begründung für eine serologische Zweistufen-Begutachtung im Abstammungsprozeß. NJW 14:590–592
Siebert G, Amorim A, Kömpf J (1980) Human phosphoglycolate phosphatase (PGP) E.C.3.1.3.18: Linkage analysis. Hum Genet 53:421
Rose ZB (1976) A procedure for decreasing the level of 2,3-biphosphoglycerate in red cells in vitro. Biochem Biophys Res Commun 73: 1011–1017
Rose ZB, Liebowitz J (1970) 2,3-Diphophosphoglycerate phosphatase from human erthrocytes. General properties and activation by anions. J Biol Chem 245:3232–3241
Sachs V, Christiansen R (1981) Untersuchungen über die Phosphoglycolat-Phosphatase in Schleswig-Holstein. (In press)
Scherz R, Pflughaupt R, Bütler R (1981) Phosphoglycolate phosphatase (PGP, EC 3.1.3.18) polymorphism in the Swiss population, its application in paternity testing (Abstract). For Sci Int 18:267
Turner MS, Hopkinson DA (1981) Biochemical characterization of the genetic variants of human phosphoglycolate phosphatase (PGP). Ann Hum Genet 45:121–127
Weil D, Van Cong N, Finaz C, Gross M-S, Cochet Ch, de Grouchy J, Frézal J (1979) Localization du gène phosphoglycolate phosphatase (PGP) sur le chromosome 16 par l'hybridation cellulaire interspecifique. Hum Genet 51:139
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Brink, W., Baur, M.P. & Rittner, C. Population, formal genetics, and linkage relations of the phosphoglycolate phosphatase (PGP)—E.C.3.1.3.18. Hum Genet 59, 386–388 (1981). https://doi.org/10.1007/BF00295477
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DOI: https://doi.org/10.1007/BF00295477