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The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

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Summary

The cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and chemicals. Using a full length cDNA clone for the human nifedipine oxidase gene (CYP3) and a panel of human-rodent somatic cell hybrids, we have assigned this gene family to chromosome 7q22-qter. A search for RFLPs using this probe yielded no results.

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Author information

Authors and Affiliations

  1. Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, EN6 3LD, South Mimms, Herts., UK

    Nigel K. Spurr & Alan C. Gough

  2. Laboratory of Molecular Pharmacology and Drug Metabolism, Imperial Cancer Research Fund, University Department of Biochemistry, Hugh Robson Building, George Square, EH8 9XP, Edinburgh, UK

    Karen Stevenson & C. Roland Wolf

Authors
  1. Nigel K. Spurr
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  2. Alan C. Gough
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  3. Karen Stevenson
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  4. C. Roland Wolf
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Additional information

The nomenclature used in this paper is that recommened by the Human Gene Mapping Nomenclature Committee 1988. The gene assignment of the CYP3 was presented as an abstract at Human Gene Mapping 9, Paris 1987

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Spurr, N.K., Gough, A.C., Stevenson, K. et al. The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter. Hum Genet 81, 171–174 (1989). https://doi.org/10.1007/BF00293896

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  • DOI: https://doi.org/10.1007/BF00293896

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