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The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6

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Summary

We have studied the segregation of the Lp(a) glycoprotein phenotypes and of the plasminogen (PLG) polymorphism in three two-generation families. The inheritance of the Lp(a) gene was followed using the Lp(a) glycoprotein size polymorphism and that of the plasminogen gene, using protein and DNA polymorphisms. In the three families studied, no recombination was observed in 18 meioses. The lod score for linkage between the Lp(a) glycoprotein locus and the plasminogen locus in these families is greater than 5.0 at a recombination fraction of θ=0. Our results show that the structural gene for the Lp(a) glycoprotein is closely linked to the gene for plasminogen on chromosome 6.

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Authors and Affiliations

  1. Charing Cross Sunley Research Centre, Lurgan Avenue, Hammersmith, W6 8LW, London, UK

    Gisela Lindahl & Steve Humphries

  2. Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020, Innsbruck, Austria

    Elisabeth Gersdorf, Han Jürgen Menzel, Christoph Duba & Gerd Utermann

  3. Institut für Humangenetik und Anthropologie der Universität, Richard-Wagner-Strasse 10/5, D-8000, München 2, Federal Republic of Germany

    Hartmut Cleve

Authors
  1. Gisela Lindahl
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  2. Elisabeth Gersdorf
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  3. Han Jürgen Menzel
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  4. Christoph Duba
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  5. Hartmut Cleve
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  6. Steve Humphries
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  7. Gerd Utermann
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Lindahl, G., Gersdorf, E., Menzel, H.J. et al. The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6. Hum Genet 81, 149–152 (1989). https://doi.org/10.1007/BF00293891

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  • DOI: https://doi.org/10.1007/BF00293891

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