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The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling

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Summary

Complex segregation analysis of Lomholt's family data on psoriasis on the Faroe Islands gave evidence for an additive major gene with gene frequency of 0.07 and penetrance 0.12 and 0.44 in the heterozygote and in the homozygote, respectively. In addition, there was a multifactorial component with heritability 0.87. The implications of these findings for genetic counseling are discussed and analytical risk figures are presented for chosen pedigrees.

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Authors and Affiliations

  1. Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden

    Lennart Iselius

  2. Population Genetics Laboratory, University of Hawaii, 96822, Honolulu, HI, USA

    Lennart Iselius

  3. Department of Medical Genetics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Wick R. Williams

Authors
  1. Lennart Iselius
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  2. Wick R. Williams
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Iselius, L., Williams, W.R. The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling. Hum Genet 68, 73–76 (1984). https://doi.org/10.1007/BF00293877

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  • DOI: https://doi.org/10.1007/BF00293877

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