Summary
The binding capacity for H-Y antigen was studied in various rat tissues of both sexes. In nongonadal tissues (liver, kidney, brain, epidermis) binding could not be demonstrated. In contrast, the gonads are able to bind exogenously supplied H-Y antigen. In the ovary, the binding capacity remains unchanged in newborn and adult animals, while in the testis, this capacity decreases with age. A receptor like that of a proteohormone is assumed to exist in the gonads but not in other tissues. In nongonadal tissues, H-Y antigen apparently is present only if the cell itself synthesizes the antigen. The H-Y antigen receptor of the gonads is not sex-specific. Thus, the primary sex differentiation depends on whether H-Y antigen is synthesized in the organism.
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Beutler, B., Nagai, Y., Ohno, S., Klein, G., Shapiro, I. M.: The HLA dependent expression of testis-organizing H-Y antigen by human male cells. Cell 13, 509–513 (1978)
Gasser, D. L., Silvers, W. K.: Genetics and immunology of sex-linked antigens. Adv. Immunol. 15, 215–247 (1972)
Goldberg, E. H., Boyse, E. A., Bennett, D., Scheid, M., Carswell, E. A.: Serological demonstration of H-Y (male) antigen on mouse sperm. Nature 232, 478–480 (1971)
Müller, U., Zenzes, M. T., Bauknecht, T., Wolf, U., Siebers, J. W., Engel, W.: Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro. Hum. Genet. (in press, 1978)
Ohno, S.: The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins. Immunol. Rev. 33, 59–69 (1977)
Ohno, S., Christian, L. C., Wachtel, S. S., Koo, G. C.: Hormone-like role of H-Y antigen in bovine freemartin gonads. Nature 261, 597–599 (1976)
Ohno, S., Ciccarese, S., Nagai, Y., Wachtel, S. S.: H-Y antigen in testes of XX(BALB)XY(C3H) chimaeric male mouse. Arch. Androl. 1, 103–109 (1978a)
Ohno, S., Nagai, Y., Ciccarese, S.: Testicular cells lysostripped of H-Y antigen organize ovarian follicle-like aggregates. Cytogenet. Cell Genet. 20, 351–364 (1978b)
Scheid, M., Boyse, E. A., Carswell, E. A., Old, L. J.: Serologically demonstrable alloantigens of mouse epidermal cells. J. Exp. Med. 135, 938–955 (1972)
Siebers, J. W., Peters, F., Zenzes, M. T., Schmidtke, J., Engel, W.: Binding of human chorionic gonadotrophin to rat ovary during development. J. Endocrinol. 73, 491–496 (1977)
Wachtel, S. S., Koo, G. L., Boyse, E. A.: Evolutionary conservation of H-Y (“male”) antigen. Nature 254, 270–272 (1975a)
Wachtel, S. S., Ohno, S., Koo, G. C., Boyse, E. A.: Possible role for H-Y antigen in the primary determination of sex. Nature 257, 235–236 (1975b)
Zenzes, M. T., Wolf, U., Engel, W.: Organization in vitro of ovarian cells into testicular structures. Hum. Genet. (in press, 1978a)
Zenzes, M. T., Wolf, U., Günther, E., Engel, W.: Studies on the function of H-Y antigen: Dissociation and reorganization experiments on rat gonadal tissue. Cytogenet. Cell Genet. 20, 365–372 (1978b)
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Müller, U., Aschmoneit, I., Zenzes, M.T. et al. Binding studies of H-Y antigen in rat tissues. Hum Genet 43, 151–157 (1978). https://doi.org/10.1007/BF00293592
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DOI: https://doi.org/10.1007/BF00293592