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Extrachromosomal inheritance of paromomycin resistance in Saccharomyces cerevisiae

Genetic and biochemical characterization of mutants

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Summary

In Saccharomyces cerevisiae, mutants were isolated which show high resistance to the aminoglycoside paromomycin. Amino acid incorporation of mitochondria isolated from such mutant strains proved also to be paromomycin resistant. All of them are cross-resistant to the structurally related antibiotic neomycin. Three independent methods revealed the resistance to be extrachromosomally, presumably mitochondrially inherited.

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Authors and Affiliations

  1. Institut für Genetik der Universität München, Munchen, Germany

    Regina Kutzleb, Rudolf J. Schweyen & Fritz Kaudewitz

Authors
  1. Regina Kutzleb
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  2. Rudolf J. Schweyen
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  3. Fritz Kaudewitz
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Communicated by W. Gajewski

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Kutzleb, R., Schweyen, R.J. & Kaudewitz, F. Extrachromosomal inheritance of paromomycin resistance in Saccharomyces cerevisiae . Molec. Gen. Genet. 125, 91–98 (1973). https://doi.org/10.1007/BF00292984

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  • DOI: https://doi.org/10.1007/BF00292984

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