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Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome

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Abstract

The distribution of mitotic chiasmata from the lymphocytes of three patients with Bloom's syndrome was studied by Q-banding. An estimate was made of the average brightness of the human chromosomes and of the brightness and length of the Q-regions. A strong relationship was found between the average darkness of a chromosome and its chiasma density. The shorter and darker Q-regions contained more chiasmata, with the exception of the chromosome tips which had lower chiasma densities. A few “hot spots” had particularly high chiasma densities. Centric regions contained 17% of the chiasmata. The data are consistent with the assumptions that chiasmata are favored in darker regions and at borders between light and dark regions.

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Author notes

  1. Evelyn Meyer Kuhn

    Present address: Institute for Developmental Research, Children's Hospital Research Foundation, Elland and Bethesda Avenues, 45229, Cincinnati, Ohio, USA

Authors and Affiliations

  1. Laboratory of Genetics, University of Wisconsin, USA

    Evelyn Meyer Kuhn

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  1. Evelyn Meyer Kuhn
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This is paper No. 1972 from the Genetics Laboratory, University of Wisconsin, Madison

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Kuhn, E.M. Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome. Chromosoma 57, 1–11 (1976). https://doi.org/10.1007/BF00292945

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  • DOI: https://doi.org/10.1007/BF00292945

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