Summary
Sixteen patients with untreated small cell carcinoma of the bronchus received cyclophosphamide in a total dose of 160–200 mg/kg. Autologous marrow transplantation was used to minimise the period of hypoplasia and 2-mercaptoethane sulphonate to prevent urothelial toxicity. The procedure was well tolerated, with predictable and manageable toxicity. Complete radiological and bronchoscopic response was achieved in seven patients and partial response in a further seven. High-dose cyclophosphamide may be a useful initial treatment for this disease.
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References
Broder LE, Cohen MH, Selawry OS (1977) Treatment of bronchogenic carcinoma. II. Small cell. Cancer Treat Rev 4:219–260
Bruckner CD, Briggs R, Clift RA (1974) Intermittent high-dose cyclophosphamide treatment of stage III ovarian carcinoma. Cancer Chemother Rep 58:697–703
Gorin NC, Najman A, Salmon C, Muller JY, Petit JC, David R, Stachowiak J, Hirsch MF, Parlier Y, Duhamel G (1979) High-dose combination chemotherapy TACC with and without autologous bone marrow transplantation for the treatment of acute leukaemia and other malignant disease. Eur J Cancer 15:1113–1119
Hansen H, Dombernowsky P, Hirsch FR (1978) Staging procedures and prognostic features in small cell anaplastic bronchogenic carcinoma. Semin Oncol 5:280–287
McElwain TJ, Hedley DW, Burton G, Clink HM, Gordon MY, Jarman M, Juttner CA, Millar JL, Milsted RAV, Prentice G, Smith IE, Spence D, Woods M (1979) Marrow autotransplantation accelerates haematological recovery in patients with malignant melanoma treated with high-dose melphalan. Br J Cancer 40:72–80
Oldham RK, Greco GA (1980) Small-cell lung cancer. A curable disease. Cancer Chemother Pharmacol 4:173–177
Scheaf W, Oklein H, Brock N (1979) Controlled clinical studies with an antidote against the urotoxicity of oxazophorines: preliminary results. Cancer Treat Rep 63:501–505
Spitzer G, Dicke KA, Litam J, Verma DS, Zander A, Lanzotti V, Valdivieso M, McCredie K, Samuels ML (1980) High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumours. Cancer 45:3075
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Souhami, R.L., Harper, P.G., Linch, D. et al. High-dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus. Cancer Chemother. Pharmacol. 8, 31–34 (1982). https://doi.org/10.1007/BF00292868
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DOI: https://doi.org/10.1007/BF00292868