Summary
It has been postulated that accessory marker chromosomes, which frequently show satellites, are effective in inducing meiotic nondisjunction in the carrier. This hypothesis has been tested by comparing expectations derived from it with actual data. Due to the discrepancies between these expectations and actual observations this hypothesis does not hold true: The frequency of trisomy 21 in the offspring of a carrier of an accessory bisatellited marker chromosome cannot be shown to be actually increased, and there is no increase of either the rate of miscarriages to such carriers or the frequency of an accessory marker chromosome among the individuals with regular trisomy 21. This indicates that the risk of trisomy in the offspring of a carrier of an accessory marker chromosome corresponds to the overall incidence of this trisomy.
References
Alberman ED, Creasy MR (1977) Frequency of chromosomal abnormalities in miscarriages and perinatal deaths. J Med Genet 14:313–315
Armendares S, Buentello L, Cuevas-Sosa A, Cantú-Garza JM (1969) Familial extra centric bisatellited chromosome. Cytogenetics 8:177–186
Bartsch HD, Azevedo Moreira LM de, Röhrborn G, Claussen U, Gebauer HJ (1980) Possible origin of a small bisatellited additional chromosome. Hum Genet 54:319–322
Borgaonkar DS, Shaffer R, Reed WC, Jackson LG, Bresnahan K, Borgaonkar M, Eleuterio M, Huntington C, Levitsky K, Sokoloff B (1982) Repository of chromosomal variants and anomalies in man. An international registry of abnormal karyotypes. Wilmington Medical Center, Wilmington DW, Affred I. du Pont Institute, Wilmington DW, University of Delaware, Newark DE, Thomas Jefferson University, Philadelphia PA
Bridges CB (1916) Nondisjunction as proof of the chromosome theory of heredity. Genetics 1:107–163
Calabro A, Lungarotti MS, Dallapiccola B (1980) A comment on the paper: Recurence of Down syndrome associated with microchromosome. By Ramos C, Rivera L, Benitez J, Tejedor E, Sanchez-Cascos A. Hum Genet 53:287–288
Hook EB, Hamerton JL (1977) The frequency of chromosome abnomalities detected in consecutive newborn studies—Differencies between studies—Results by sex and by severity of phenotypic involvement. In: Hook EB, Porter IH (eds) Population cytogenetics studies in humans. Academic Press, New York, pp 63–79
Mulcahy MT, Jenkyn J (1972) Results on 538 chromosome studies on patients referred for cytogenetic analysis. Med J Aust 2: 1333–1338
Ramos C, Rivera L, Benitez J, Tejedor E, Sanchez-Cascos A (1979) Recurrence of Down syndrome associated with microchromosome. Hum Genet 49:7–10
Ricci N, Ventimiglia B, Preto G (1968) Transmission d'un petit chromosome surnumeraire dans une familie avec deux cas de trisomie 21. Ann Génét (Paris) 11:114–116
Steinbach P, Djalali M, Hansmann I, Kattner E, Meisel-Stosiek M, Probeck HD, Schmidt A, Wolf M (1983) The genetic significance of accessory bisatellited marker chromosomes. Hum Genet (in press)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Steinbach, P., Djalali, M. Ineffectivity of accessory bisatellited marker chromosomes in inducing meiotic nondisjunction. Hum Genet 64, 402–403 (1983). https://doi.org/10.1007/BF00292376
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00292376