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Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6

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Summary

Viral leukemogenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called Pim-1. Here we report the chromosomal localization of the human homologue by Southern blot analyses of DNAs obtained from human-rodent somatic cell hybrids. The single copy human homologue was assigned to the 6pter-q12 segment.

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References

  • Bishop JM, Varmus HE (1982) RNA tumor viruses. In: Weiss RA, Teich N, Varmus HE, Coffin J (eds) The molecular biology of tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 999–1009

    Google Scholar 

  • Bodmer WF, Bodmer JG (1978) Evolution and function of the HLA system. Br Med Bull 34:309–316

    Google Scholar 

  • Corcoran LM, Adams JM, Dunn AR, Cory S (1984) Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37:113–122

    Google Scholar 

  • Croce CM, Thierfelder W, Erikson J, Nishikura K, Finan J, Lenoir GM, Nowell P (1983) Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a Cλ locus in Burkitt lymphoma cells. Proc Natl Acad Sci USA 80:6922–6926

    Google Scholar 

  • Cuypers HT, Selten G, Quint W, Zijlsta M, Robanus-Maandag E, Boelens W, van Wezenbeek P, Melief C, Berns A (1984) Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37:141–150

    Google Scholar 

  • Fung YKT, Lewis WG, Kung HJ, Crittenden LB (1983) Activation of the cellular oncogene c-erbB by LTR insertion; molecular basis for induction of erythroblastosis by avian leukosis virus. Cell 33:357–368

    Google Scholar 

  • Geurts van Kessel AHM, ten Brinke H, Boere WAM, den Boer WC, de Groot PG, Hagemeijer A, Meera Khan P, Pearson PL (1981) Characterization of the Philadelphia chromosome by gene mapping. Cytogenet Cell Genet 30:83–91

    Google Scholar 

  • Geurts van Kessel AHM, Tetteroo PAT, von dem Borne AEGKr, Hagemeijer A, Bootsma D (1983) Expression of human myeloid associated surface antigens in human-mouse myeloid cell hybrids. Proc Natl Acad Sci USA 80:3748–3751

    Google Scholar 

  • Hayward WS, Neel BG, Astrin S (1981) Activation of a cellular onc gene by promotor insertion in ALV-induced lymphoid leukosis. Nature 290:475–480

    Google Scholar 

  • Heisterkamp N, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, Grosveld G (1983) Localization of the c-able oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature 306:239–242

    Google Scholar 

  • Hilkens J, Cuypers HTh, Selten G, Kroezen V, Hilgers J, Berns A (1986) Genetic mapping of the Pim-1 putative oncogene to mouse chromosome 17. Somatic Cell Mol Genet 12:1–8

    Google Scholar 

  • Klein G (1983) Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and man. Cell 32:311–315

    Google Scholar 

  • Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R (1983) Translocation among antibody genes in human cancer. Science 222:765–771

    Google Scholar 

  • Miyamoto K, Tomita N, Ishii A, Nonaka H, Kondo T, Tanaka T, Kitajima K (1984) Chromosome abnormalities of leukemia cells in adult patients with T-cell leukemia. JNCI 73:353–362

    Google Scholar 

  • Nadeau JH, Taylor B (1984) Lengths of chromosomal segments conserved since divergence of man and mouse. Proc Natl Acad Sci USA 81:814–818

    Google Scholar 

  • Neel BG, Hayward WS, Robinson HL, Fang J, Astrin SM (1981) Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promotor insertion. Cell 23:323–334

    Google Scholar 

  • Neil JC, Hughes D, McFarlane R, Wilkie NM, Onions DE, Lees G, Jarret O (1984) Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukemias. Nature 308:814–820

    Google Scholar 

  • Nusse R, Varmus HE (1982) Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31:99–109

    Google Scholar 

  • Payne GS, Bishop JM, Varmus HE (1982) Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature 295:209–214

    Google Scholar 

  • Peters G, Brookes S, Smith R, Dickson C (1983) Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors. Cell 33:369–377

    Google Scholar 

  • Robson EB, Lamm LU (1983) Report of the committee on the genetic constitution of chromosome 6. Cytogenet Cell Genet 37:47–70

    Google Scholar 

  • Selten G, Cuypers HT, Zijlstra M, Melief C, Berns A (1984) Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO J 3:3215–3222

    Google Scholar 

  • Selten G, Cuypers HTh, Berns A (1985) Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J 4:1793–1798

    Google Scholar 

  • Swift RA, Shaller E, Witter RL, Kung HJ (1985) Insertion activation of c-myc by reticuloendotheliosis virus in chicken B lymphoma: nonrandom distribution and orientation of the proviruses. J Virol 54:869–872

    Google Scholar 

  • Teich N, Wyke J, Mak T, Bernstein A, Hardy W (1982) Pathogenesis of retrovirus-induced disease. In: Weiss RA, Teich N, Varmus HE, Coffin J (eds) RNA tumor viruses. The molecular biology of tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 785–998

    Google Scholar 

  • van Someren H, Westerveld A, Hagemeijer A, Mees JR, Meera Khan P, Zaalberg OB (1974) Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between HL-A, PGMe, ME1 and IPO-B loci. Proc Natl Acad Sci USA 71:962–965

    Google Scholar 

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Cuypers, H.T., Selten, G., Berns, A. et al. Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6. Hum Genet 72, 262–265 (1986). https://doi.org/10.1007/BF00291892

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  • DOI: https://doi.org/10.1007/BF00291892

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