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Beitrag zur Populationsgenetik der Pyruvatkinase menschlicher Erythrocyten

Population genetics of pyruvate kinase from red blood cells

ATP-Pyruvate phosphotransferase, E.C.2.7.1.40

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Summary

In 214 healthy young Germans the activity of Pyruvatekinase from red blood cells has been determined. Three persons had values in the heterozygote range between 10.0 and 20.0 U. Suggesting a 2-allele-model the frequency of the three phenotypes in the German population can be calculated as followed: PK(A)=98.6%, PK(AB)=1.4%, PK(B)=0.005%.

No correlation could be found between the distribution of blood-and serum-groups and the enzyme-activity.

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Authors and Affiliations

  1. Medizinische Universitäts-Poliklinik Marburg a. d. Lahn, Marburg a. d. Lahn, Deutschland

    K. G. Blume, G. W. Löhr, O. Praetsch & H. W. Rüdiger

  2. Institut für Humangenetik der Universität Marburg a. d. Lahn, Marburg a. d. Lahn, Deutschland

    G. G. Wendt

Authors
  1. K. G. Blume
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  2. G. W. Löhr
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  3. O. Praetsch
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  4. H. W. Rüdiger
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  5. G. G. Wendt
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Additional information

Direktor: Prof. Dr. med. G. W. Löhr

Direktor: Prof. Dr. med. G. G. Wendt

Mit dankenswerter Unterstützung durch die Deutsche Volkswagen-Stiftung.

Herrn Professor Dr.H. E. Bock, Tübingen, zum 65. Geburtstag gewidmet. Wesentliche Teile dieser Arbeit werden von Olaf Praetsch der Medizinischen Fakultät als Dissertation vorgelegt.

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Blume, K.G., Löhr, G.W., Praetsch, O. et al. Beitrag zur Populationsgenetik der Pyruvatkinase menschlicher Erythrocyten. Hum Genet 6, 261–265 (1968). https://doi.org/10.1007/BF00291870

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  • DOI: https://doi.org/10.1007/BF00291870

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