Summary
The locus coding for the A subunit of coagulation factor XIII (F13A) is strongly linked with the major histocompatibility complex on chromosome 6. The maximum lod score was obtained at recombination fractions of 0.12 in males and 0.40 in females. The data suggest that the F13A locus is distal to HLA, probably within the 6p22 region.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berger R, Bernheim A, Sasportes M, Hauptmann G, Hors J, Legrand L, Fellows M (1979) Regional mapping of HLA on the short arm of chromosome 6. Clin Genet 15:245–351
Board PG (1979) Genetic polymorphism of the A subunit of human coagulation factor XIII. Am J Hum Genet 31:116–124
Board PG (1980) Genetic polymorphism of the B subunit of human coagulation factor XIII. Am J Hum Genet 31:348–353
Board PG, Coggan M (1981) Polymorphism of the A subunit of coagulation factor XIII in the Pacific region. Description of new phenotypes. Hum Genet 59:135–136
Board PG, Coggan M, Hamer JW (1980) An electrophoretic and quantitative analysis of coagulation factor XIII in normal and deficient subjects. Br J Haematol 45:633–640
Castle SL, Board PG (1983) Biochemical characterization of genetically variant and abnormal blood coagulation factor XIII A subunits. Clin Chim Acta 133:141–151
Castle SL, Board PG (1984) An extended survey of the genetic polymorphism at the human coagulation factor XIII A subunit structural locus. Hum Hered (to be published)
Castle S, Board PG, Anderson RAM (1981) Genetic heterogeneity of factor XIII deficiency: first description of unstable A subunits. Br J Haematol 48:337–342
Cook PJL, Noades JE, Lomas CG, Buckton KE, Robson EB (1980) Exclusion mapping illustrated by the MNSs blood group. Ann Hum Genet 44:61–73
Harris H, Hopkinson DA (1976) Handbook of enzyme electrophoresis in human genetics. North Holland, Amsterdam
Kreckel P, Kuhnl P, Spielmann W (1982) Human coagulation factor XIII (FXIIIA) phenotyping by immunofixation agarose gel electrophoresis (IAGE). Blut 44:309–314
McDonagh J, McDonagh RP, Duckert F (1971) Genetic aspects of factor XIII deficiency. Ann Hum Genet 35:197–206
Mulley JC, Hay J, Sheffield LJ, Sutherland GR (1983) Regional localization for HLA by recombination with a fragile site at 6p23. Am J Hum Genet 35:1284–1288
Nishigaki T, Omoto K, Juji T (1981) Genetic polymorphism of the A subunit of human coagulation factor XIII in Japanese. Jpn J Hum Genet 26:237–241
Olaisen B, Silverts A, Gedde-Dahl T Jr, Tiesberg P, Jonassen R, Thorsby E (1983) Linkage data for the coagulation factor genes FXIIIA and FXIIIB. International Human Gene Mapping Workshop VII. UCLA
Ott J (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28:528–529
Ratnoff OD, Steinberg AG (1968) Inheritance of fibrin stabilizing factor deficiency. Lancet 1:25–26
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Board, P.G., Reid, M. & Serjeantson, S. The gene for coagulation factor XIII a subunit (F13A) is distal to HLA on chromosome 6. Hum Genet 67, 406–408 (1984). https://doi.org/10.1007/BF00291400
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00291400