Abstract
Intracisternal A-particle (IAP) proviral elements are moderately reiterated and widely dispersed in the mouse genome. Oligonucleotide probes have been derived from three distinctive IAP element subfamilies (LS elements) that are transcriptionally active in normal mouse B- and T-cells. In HindIII digests, LS element-specific oligonucleotides each react with a limited number of restriction fragments that represent junctions between proviral and flanking DNA. These fragments have characteristic strain distribution patterns (SDPs) which are polymorphic in the DNAs of different mouse strains. We have established chromosomal assignments for 44 LS proviral loci by comparing their SDPs with those of known genetic markers in the BXD set of RI mouse strains. Some of the loci have also been scored in the CXB RI set. The IAP LS loci can provide a significant number of markers with a recognized genetic organization to the mouse genome map.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernier, L., Colman, D.R., and D'Eustachio, P.: Chromosomal locations of genes encoding 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and glial fibrillary acidic protein in the mouse. J Neurosci Res 20: 497–504, 1988.
Blatt, C., Saxe, D., Marzluff, W.F., Lobo, S., Nesbitt, M.N., and Simon, M.I.: Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequences, amylase and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet 14: 133–142, 1988.
Bottaro, D.P., Rubin, J.S., Faletoo, D.L., Chan, A. M-L., Kmiecik, T.E., Vande Woude, G.F., and Aaronson, S.A.: Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 251: 802–804, 1991.
Brilliant, M.Y., Gondo, Y., and Eicher, E.M.: Direct molecular identification of the mouse pink-eyed unstable mutation by genome scanning. Science 252: 566–569, 1991.
Campbell, G.R., Zimmerman, K., Blank, R.D., Alt, F.W., and D'Eustachio, P.: Chromosomal location of N-myc and L-myc genes in the mouse. Oncogene Res 4: 47–54, 1989.
Collins, M.S. and Hunsaker, W.R.: Improved hybridization assays employing tailed oligonucleotide probes: a direct comparison with 5′-end-labeled oligonucleotide probes and nick-translated plasmid probes. Anal Biochem 151: 211–244, 1985.
Cornall, R.J., Aitman, T.J., Hearne, C.M., and Todd, J.A.: The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics 10: 874–881, 1991.
Dean, M., Kozak, C., Robbins, J., Callahan, R., O'Brien, S., and Vande Woude, G.F.: Chromosomal localization of the met protooncogene in the mouse and cat genome. Genomics 1: 167–173, 1987.
Devlin, P.E., Ramachandran, K.L., and Cate, R.L.: Southern analysis of genomic DNA with unique and degenerate oligonucleotide probes: a method for reducing probe degeneracy. DNA 7: 499–507, 1988.
Dietrich, W.F., Katz, H., Lincoln, S.E., Shin, H.-S., Friedman, J., Dracopoli, N., and Lander, E.S.: A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131: 423–447, 1992.
DiLella, A.G. and Woo, S.L.C.: Hybridization of genomic DNA to oligonucleotide probes in the presence of tetramethylammonium chloride. In S.L. Berger and A.R. Kimmel (eds.); Guide to Molecular Cloning Techniques, pp. 447–451, Academic Press, New York, 1987.
Douville, P.J. and Carbonetto, S.: Genetic linkage analysis in recombinant inbred mice of P40, a putative clone for high-affinity laminin receptor. Mammalian Genome 3: 438–446, 1992.
Elliott, R.W. and Yen, C-H.: DNA variants with telomere probe enable genetic mapping of ends of mouse chromosomes. Mammalian Genome 1: 118–122, 1991.
Engler, P., Haasch, D., Pinkert, C.A., Doglio, L., Glymour, M., Brinster, R., and Storb, U.: A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell 65: 939–947, 1991.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic analysis of endogenous xenotropic murine leukemia viruses: association with two common mouse mutations and the viral restriction locus Fv-1. J Virol 63: 1763–1774, 1989a.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63: 3810–3821, 1989b.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: A linkage map of endogenous murine leukemia proviruses. Genetics 124: 221–236, 1990.
Frankel, W.N., Lee, B.K., Stoye, J.P., Coffin, J.M., and Eicher, E.M.: Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/BINJ and SM/J inbred strains. Mammalian Genome 2: 110–122, 1992.
Gora-Maslak, G., Smith, D.L., Plomin, R., and McClearn, G.E.: Prm-1 and DXWas 17 RFLP polymorphisms identify novel SDPs in the BXD RI strains. Mouse Genome 89: 852, 1991.
Hillyard, A.L., Doolittle, D.P., Davisson, M.T., and Roderick, T.H.: Locus map of mouse with comparative map points of human on mouse. The Jackson Laboratory, July 1992.
Jeffries, A.R., Wilson, V., Kelly, R., Taylor, B.A., and Bulfield, G.: Mouse DNA ‘fingerprints”: analysis of chromosome location and germ-line stability of hypervariable loci in recombinant inbred mice. Nucleic Acids Res 15: 2823–2836, 1987.
Jenkins, N.A. and Copeland, N.G.: Retroviral DNA content of the mouse genome. Birth Defects 23: 109–122, 1987.
Johnson, K.R.: Improved oligonucleotide labeling and hybridization assay for endogenous nonecotropic murine leukemia proviruses. Mammalian Genome 1: 260–262, 1991.
Jolicoeur, P.: The Fv-1 gene of the mouse and its control of murine leukemia virus replication. Curr Top Microbiol Immunol 86: 67–122, 1979.
Kipling, D., Ackford, H.E., Taylor, B.A., and Cooke, H.J.: Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere. Genomics 11: 874–881, 1991.
Kuff, E.L. and Fewell, J.W.: Intracisternal A-particle gene expression in normal mouse thymus tissue: gene products and strain-related variability. Mol Cell Biol 5: 474–483, 1985.
Kuff, E.L. and Lueders, K.K.: Intracisternal A-particle gene family: structural and functional aspects. Adv Cancer Res 51: 183–276, 1988.
Lee, B.K. and Eicher, E.E.: Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets. J Virol 64: 4568–4572, 1990.
Lueders, K.K. and Kuff, E.L.: Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library. Proc Natl Acad Sci USA 77: 3571–3575, 1980.
Manly, K.F. and Elliott, R.W.: RI Manager, a computer program for analysis of data from recombinant inbred strains. Mammalian Genome 1: 123–126, 1991.
Meinkoth, J. and Wahl, G.: Hybridization of nucleic acids immobilized on solid support. Anal Biochem 138: 267–284, 1984.
Mietz, J.A. and Kuff, E.L.: IAP-specific oligonucleotides provide multilocus probes for genetic linkage studies in the mouse. Mammalian Genome 3: 447–451, 1992.
Mietz, J.A., Grossman, Z., Lueders, K.K., and Kuff, E.L.: Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function. J Virol 61: 3020–3029, 1987.
Mietz, J.A., Fewell, J.W., and Kuff, E.L.: Selective activation of a discrete family ofendogenous proviral elements in normal BALB/c lymphocytes. Mol Cell Biol 12: 220–228, 1992.
Mullins, J.J., Zeng, Q., and Gross, K.W.: Mapping of the mouse atrial natriuretic factor gene. Hypertension 9: 518–521, 1987.
Nadeau, J.H., Bedigian, H.G., Bouchard, G., Denial, T., Kosowsky, M., Norberg, R., Pugh, S., Sargeant, E.S., Turner, R., and Paigen, B. Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence. Mammalian Genome 3: 55–64, 1992.
Neumann, P.E.: Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem. Genetics 126: 277–284, 1990.
Poznanski, A.A. and Calarco, P.G.: The expression of intracisternal A particle genes in the preimplantation mouse embryo. Dev Biol 143: 271–281, 1991.
Sanford, J.P., Clark, H.J., Chapman, V.M., and Rossant, J.: Differences to DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev 1: 1039–1046, 1987.
Sarvetnick, N. Tsai, J-Y, Fox, H., Pilder, S.H., and Silver, L.M.: A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. Immunogenetics 30: 34–41, 1989.
Stoye, J.P. and Coffin, J.M.: Polymorphism of murine endogenous proviruses revealed by using virus class-specific oligonucleotide probes. J Virol 62: 168–175, 1988.
Taylor, B.A.: Recombinant inbred strains. In M.F Lyon and A.G. Searle (eds.); Genetic Variants and Strains of the Laboratory Mouse, pp. 773–796, Oxford University Press, Oxford, 1989.
Vincek, V., Kawaguchi, H., Mizuno, K., Zaleska-Rutczynaska, Z., Kasahara, M., Fore, J.T., Figueroa, F., and Klein, J.: Linkage map of mouse chromosome 17: localization of 27 new DNA markers. Genomics 5: 773–786, 1989.
Wallace, R.B. and Miyada, C.G.: Oligonucleotide probes for the screening of recombinant DNA libraries. In S.L. Berger and A.R. Kimmel (eds.): Guide to Molecular Cloning Techniques, pp. 432–442, Academic Press, New York, 1987.
Wood, W.I., Gitschier, J., Lasky, L.A., and Lawn, R.M.: Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screeing of highly complex gene libraries. Proc Natl Acad Sci USA 82: 1585–1588, 1985.
Woodward, S.R., Sudweeks, J., and Teuscher, C.: Random sequence oligonucleotide primers detect polymorphic DNA products which segregate in inbred strains of mice. Mammalian Genome 3: 73–78, 1992.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lueders, K.K., Frankel, W.N., Mietz, J.A. et al. Genomic mapping of intracisternal A-particle proviral elements. Mammalian Genome 4, 69–77 (1993). https://doi.org/10.1007/BF00290429
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00290429