Skip to main content
Log in

Meiotic studies in human semen

Report of 180 cases

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

Meiotic studies can be carried out in the spermatogenic cells present in ejaculate. Using this technique, we identified one man with a reciprocal translocation and six oligochiasmatic males among 180 patients studied. The technique is easy and reliable; good-quality figures can be obtained, and meiotic studies can be carried out as often as needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Chaganti, R. S. K., German, J.: Human male infertility, probably genetically determined, due to defective meiotic pairing and chiasma formation. Am. J. Hum. Genet. 26, 19A (1974)

  • Chandley, A. C.: The chromosomal basis of human infertility. Br. Med. Bull. 35, 181–186 (1979)

    CAS  PubMed  Google Scholar 

  • Chandley, A. C., Maclean, N., Edmond, P., Fletcher, J., Watson, G. S.: Cytogenetics and infertility in man. II. Testicular histology and meiosis. Results of a five year survey of men attending a subfertility clinic. Ann. Hum. Genet. 40, 165–176 (1976)

    Article  CAS  PubMed  Google Scholar 

  • Dutrillaux, B., Guéguén, J.: Anomalies méiotiques et gamétiques multiples dans un cas de stérilité masculine. Ann. Genet. (Paris) 14, 49–52 (1971)

    CAS  Google Scholar 

  • Ferguson-Smith, M. A.: Meiosis in the human male. In: Chromosomes Today, Vol. 5, P. L. Pearson, K. R. Lewis (eds.), pp. 33–41. New York: John Wiley 1976

    Google Scholar 

  • Kjessler, B.: Facteurs génétiques dans la subfertilité mâle. In: Fécondité et stérilité du mâle, M. Durchon (ed.), pp. 205–225. Paris: Masson 1972

    Google Scholar 

  • Koulischer, L., Schoysman, R.: Chromosomes and human infertility. I. Mitotic and meiotic chromosome studies in 202 consecutive male patients. Clin. Genet. 5, 116–126 (1974)

    Article  CAS  PubMed  Google Scholar 

  • Hendry, W. F., Polani, P. E., Pugh, R. C. B.: The effect of meiotic chromosome abnormalities in male subfertility. Int. J. Androl. Suppl. 1, 156 (1978)

    Google Scholar 

  • Hultén, M., Eliasson, R., Tillinger, K. G.: Low chiasma count and other meiotic irregularities in two infertile 46,XY men with spermatogenic arrest. Hereditas 65, 285–290 (1970)

    Article  PubMed  Google Scholar 

  • Hultén, M., Solari, A. J., Skakkebaek, N. E.: Abnormal synaptonemal complex in an oligo-chiasmatic man with spermatogenic arrest. Hereditas 78, 105–116 (1974a)

    Article  PubMed  Google Scholar 

  • Hultén, M., de Weerd-Kastelein, E. A., Bootsma, D., Solari, A. J., Skakkebaek, N. E., Swanbeck, G.: Normal chiasma formation in a male with xeroderma pigmentosum. Hereditas 78, 117–124 (1974b)

    Article  PubMed  Google Scholar 

  • Miró, R., Templado, C., Ponsá, M., Serradell, J., Marina, S., Egozcue, J.: Balanced translocation (10;13) in the father, ascertained through the study of meiosis in semen, and partial trisomy 10q in his son. Hum. Genet. (in press, 1980)

  • Nicklas, R. B.: Chromosome distribution: experiments on cell hybrids and in vitro. Philos. Trans. R. Soc. Lond. [Biol.] 277, 267–276 (1977)

    Article  CAS  Google Scholar 

  • Pathak, S., Hsu, T. C.: Silver-stained structures in mammalian meiotic prophase. Chromosoma 70, 195–203 (1979)

    Article  CAS  PubMed  Google Scholar 

  • Pearson, P. L., Ellis, J. D., Evans, H. J.: A gross reduction in chiasma formation during meiotic prophase and a defective DNA repair mechanism associated with a case of human male infertility. Cytogenetics 9, 460–467 (1970)

    Article  CAS  PubMed  Google Scholar 

  • Skakkebaek, N. E., Bryant, J. J., Philip, J.: Studies on meiotic chromosomes in infertile men and controls with normal karyotypes. J. Reprod. Fertil. 35, 23–36 (1973)

    Article  CAS  PubMed  Google Scholar 

  • Sperling, K., Kaden, R.: Meiotic studies of the ejaculated seminal fluid of humans with normal sperm count and oligospermia. Nature 232, 481 (1971)

    Article  CAS  PubMed  Google Scholar 

  • Templado, C., Marina, S., Egozcue, J.: Three cases of low chiasma frequency associated with infertility in man. Andrologia 8, 285–289 (1976)

    Article  CAS  PubMed  Google Scholar 

  • Templado, C., Marina, S., Egozcue, J.: Meiotic studies in infertile and sterile males. Int. J. Androl. Suppl. 1, 155 (1978a)

    Article  Google Scholar 

  • Templado, C., Marina, S., Suárez Canal, F., Gil-Vernet, E., Izquierdo, L., Egozcue, J.: Four cases of low chiasma frequency diagnosed in semen. Int. J. Androl. 1, 153–161 (1978b)

    Article  Google Scholar 

  • Thomson, E., Fletcher, J., Chandley, A. C., Kučerová, M.: Meiotic and radiation studies in four oligochiasmatic men. J. Med. Genet. 16, 270–277 (1979)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Templado, C., Marina, S., Coll, M.D. et al. Meiotic studies in human semen. Hum Genet 53, 335–339 (1980). https://doi.org/10.1007/BF00287052

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00287052

Keywords

Navigation