Summary
In a previous report (Zenzes et al., 1978 b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was used as a parameter characteristic for the newborn testis, but not for the newborn ovary. In the converted ovary, the LH/hCG receptor becomes detectable a few hours after onset of the culture and remains continuously present afterward. The appearance of this receptor may be due to a hormone-like action of H-Y antigen.
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Müller, U., Zenzes, M.T., Bauknecht, T. et al. Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro. Hum. Genet. 45, 203–207 (1978). https://doi.org/10.1007/BF00286964
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DOI: https://doi.org/10.1007/BF00286964