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Regional localization of human ecto-5′nucleotidase to chromosome 6q14–q21

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Summary

Human and mouse hybrids that contain fragments of human chromosome 6 as translocations were analysed for expression of ecto-5′nucleotidase enzymic activity measured by the conversion of AMP to adenosine and for antigenicity recognized by a monoclonal antibody specific for the human isozyme. Both methods allow a regional assignment of ecto-5′nucleotidase to 6q14–q21.

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Authors and Affiliations

  1. Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, M20 9BX, Manchester, UK

    J. M. Boyle, Y. Hey & M. Fox

  2. Institut für Humangenetik und Genetische Poliklinik, Klinikum der Philipp-Universität, Bannhofstrasse 7a, D-3550, Marburg/Lahn, Germany

    K. -H. Grzeschik

  3. Department of Immunology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    L. Thompson

  4. Genetics Laboratory, Department of Biochemistry, Oxford University, OX1 5RG, Oxford, UK

    E. Munro

Authors
  1. J. M. Boyle
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  2. Y. Hey
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  3. K. -H. Grzeschik
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  4. L. Thompson
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  5. E. Munro
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  6. M. Fox
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Boyle, J.M., Hey, Y., Grzeschik, K.H. et al. Regional localization of human ecto-5′nucleotidase to chromosome 6q14–q21. Hum Genet 83, 179–180 (1989). https://doi.org/10.1007/BF00286714

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  • DOI: https://doi.org/10.1007/BF00286714

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