Summary
The growth rates of immobilized Penicillium chrysogenum strains are important in their application to semicontinuous penicillin production. Immobilized P. chrysogenum strains produced about 10–15% less biomass but about 1–2 times more penicillin than free suspended mycelia.
In a chemically defined medium an industrial P. chrysogenum strain, S1, produced about 10–12 times more penicillin than strain ATCC 12690. In a complex medium the immobilized P. chrysogenum S1 produced about 12% penicillin more than in shaken cultures. In bubble column fermentations, penicillin production was 163% higher in the complex medium than in the chemically defined medium.
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El-Sayed, AH.M.M., Rehm, H.J. Semicontinuous penicillin production by two Penicillium chrysogenum strains immobilized in calcium alginate beads. Appl Microbiol Biotechnol 26, 211–214 (1987). https://doi.org/10.1007/BF00286310
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DOI: https://doi.org/10.1007/BF00286310