Skip to main content
SpringerLink
Log in

Virus-induced gene mutations of eukaryotic cells

  • Review Articles
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

Most animal viruses studied so far induce chromosomal aberrations. In addition, adenoviruses, papovaviruses, and retroviruses are known to induce gene mutations like mutagenic bacteriophages. At least in one case studied retrovirus induced mutagenesis involves gene and/or scripton splitting analogous to the mutagenic mechanism of action of mutatorphage Mu and other movable DNA elements. On the contrary, several results obtained by independent means indicate that Simian virus 40, a papovavirus, does not act by splitting the affected gene but presumably by generation of base pair substitutions or of other minor DNA damages leading to amino acid substitutions. The mechanisms involved are still unknown. There a some hints, however, that these mechanisms might have some step(s) in common with processes leading to malignancy. In fact those viruses proved unequivocally so far to be capable of inducing gene mutations are oncogenic viruses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abbondandolo A (1977) Prospects for evaluating genetic damage in mammalian cells in culture. Mutat Res 42:279–298

    CAS  PubMed  Google Scholar 

  • Abrahams PJ, Van Der Eb AJ (1975) In vitro transformation of rat and mouse cells by DNA from simian virus 40. J Virol 16:206–209

    CAS  PubMed  PubMed Central  Google Scholar 

  • Arber W (1981) Das Bakterium E. coli unter der Lupe der Molekular-genetiker. Mannheimer Forum 81/82. Boehringer, Mannheim, pp 9–81

    Google Scholar 

  • Arber W, Kümbelin M, Caspers P, Reif HJ, Iida S, Meyer J (1981) Spontaneous mutations in the Escherichia coli prophage P1 and IS-mediated processes. Cold Spring Harbor Symp Quant Biol 45:38–40

    Google Scholar 

  • Astrin SM (1978) Endogenous viral genes of the White Leghorn chicken: Common site of residence and sites associated with specific phenotypes of viral gene expression. Proc Natl Acad Sci USA 75:5941–5945

    CAS  PubMed  PubMed Central  Google Scholar 

  • Baker RM (1979) Nature and use of ouabain-resistant mutants. In: Hsie AW, O'Neill JP, McElheny VK (eds) Banbury Report 2. Mammalian cell mutagenesis: The maturation of test systems. Cold Spring Harbor Laboratory, New York, pp 237–247

    Google Scholar 

  • Barrett JC, Crawford BD, Ts'O POP (1980) The role of somatic mutation in a multistage model of carcinogenesis. In: Mishra N, Dunkel VC, Mehlman M (eds) Mammalian cell transformation by chemical carcinogens. Senate Press Inc, New Jersey, pp 467–501

    Google Scholar 

  • Bartsch HD (1970) Virus-induced chromosomal alterations in mammals and man. In: Vogel F, Röhrborn G (eds) Chemical mutagenesis in mammals and man. Springer, Berlin Heidelberg New York, pp 420–432

    Google Scholar 

  • Bellett AJD (1977) Variants of mouse cells induced by infection with adenovirus. Proc Aust Biochem Soc 10:67

    Google Scholar 

  • Bellett AJD, Younghusband HB (1979) Spontaneous, mutagen-induced and adenovirus-induced anchorage independent tumorigenic variants of mouse cells. J Cell Physiol 101:33–47

    CAS  PubMed  Google Scholar 

  • Bender MA, Brockman WW (1981) Rearrangement of integrated viral DNA sequences in mouse cells transformed by simian virus 40. J Virol 38: 872–879

    CAS  PubMed  PubMed Central  Google Scholar 

  • Benn PA, Kelley RI, Mellman WJ, Amer L, Boches FS, Markus HB, Nichols W, Hoffman B (1981) Reversion from deficiency of galactose 1 phosphate uridyl-transferase (GALT) in an SV40-transformed human fibroblast line. Somatic Cell Genet 7:667–682

    CAS  PubMed  Google Scholar 

  • Bingham PM, Judd BH (1981) A copy of the copia transposable element is very tightly linked to the w allele at the white locus of D. melanogaster. Cell 25:705–711

    CAS  PubMed  Google Scholar 

  • Bishop JM (1981) Enemies within: the genesis of retrovirus oncogenes. Cell 23:5–6

    CAS  PubMed  Google Scholar 

  • Breitburd F, Favre M, Zoorob R, Fortin D, Orth A (1981) Detection and characterization of viral genomes and search for tumoral antigens in two hamster cell lines derived from tumors induced by bovine papillomavirus type-1. Int J Cancer 27:693–702

    CAS  PubMed  Google Scholar 

  • Bukhari AI, Shapiro JA, Adhya SL (eds) (1977) DNA insertion elements, plasmids, and episomes. Cold Spring Harbor Laboratory, Cold Spring Harbor

    Google Scholar 

  • Buzhievskaya TI, Lukash LL (1980) Virus-induced mutagenesis in mammalian cells. Zh Obshch Biol 41:918–923

    Google Scholar 

  • Cairns J (1981) The origin of human cancers. Nature 289:353–357

    CAS  PubMed  Google Scholar 

  • Campbell A (1962) Episomes. Adv Genet 11:101–145

    Google Scholar 

  • Chain HW, Garon CF, Chang EH, Lowry DR, Hager G, Scolnick EM, Repaske R, Martin MA (1980) Molecular cloning of the Harvey sarcoma virus circular DNA intermediates. II. Further structural analysis. J Virol 33:845–855

    Google Scholar 

  • Chaleff D, Fink G (1980) Genetic events associated with an insertion mutation in yeast. Cell 21:227–237

    CAS  PubMed  Google Scholar 

  • Chang C-C, Trosko JE, Akera T (1978) Characterization of ultraviolet light-induced ouabain-resistant mutations in Chinese hamster cells. Mutat Res 51:85–98

    CAS  PubMed  Google Scholar 

  • Cornelis JJ, Lupker JH, Van Der Eb AJ (1980) UV-reaction, virus production and mutagenesis of SV40 in UV-irradiated monkey kidney cells. Mutat Res 71:139–146

    CAS  PubMed  Google Scholar 

  • Cornelis JJ, Su ZZ, Ward DC, Rommelaere J (1981) Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or SV40. Proc Natl Acad Sci USA 78:4480–4484

    CAS  PubMed  PubMed Central  Google Scholar 

  • Crawford LV, Lane DP, Denhardt DT, Harlow EE, Nicklin PM, Osborn K, Pim DC (1980) Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells. Cold Spring Harbor Symp Quant Biol 44:179–187

    CAS  PubMed  Google Scholar 

  • Crawford LV, Pim DC, Gurney EG, Goodfellow P, Taylor-Paradimitriou J (1981) Detection of a common feature in several human tumor cell lines—a 53,000-dalton protein. Proc Natl Acad Sci USA 78:41–45

    CAS  PubMed  PubMed Central  Google Scholar 

  • Day RS III, Ziolkowski CHJ, Scudiero DA, Meyer SA, Lubiniecki AS, Girardi AJ, Galloway SM, Bynum GD (1980) Defective repair of alkylated DNA by human tumors and SV40-transformed human cell strains. Nature 288:724–727

    CAS  PubMed  Google Scholar 

  • DeLeo AB, Jay G, Apella E, DuBois GC, Law LW, Old LJ (1979) Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci USA 76:2420–2424

    CAS  PubMed  PubMed Central  Google Scholar 

  • Diamond L, Knorr R, Shimizu Y (1974) Enhancement of simian virus 40-induced transformation of Chinese hamster embryo cells by 4-nitroquinoline 1-oxide. Cancer Res 34:2599–2604

    CAS  PubMed  Google Scholar 

  • Echols H (1981) SOS functions, cancer and inducible evolution. Cell 25:1–2

    CAS  PubMed  Google Scholar 

  • Erickson LC, Bradley MO, Ducore JM, Ewig RAG, Kohn KW (1980a) DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas. Proc Natl Acad Sci USA 77:467–471

    CAS  PubMed  PubMed Central  Google Scholar 

  • Erickson LC, Laurent G, Sharkey NA, Kohn KW (1980b) DNA crosslinking and monoadduct repair in nitrosourea-treated human tumor cells. Nature 288:727–729

    CAS  PubMed  Google Scholar 

  • Farabaugh P, Fink G (1980) Insertion of the eukaryotic transposable element Tyl creates a 5 bp duplication. Nature 286:352–356

    CAS  PubMed  Google Scholar 

  • Favera RD, Gelmann EP, Gallo RC, Wong-Staal F (1981) A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus. Nature 292:31–35

    Google Scholar 

  • Fink G, Farabaugh P, Roeder G, Chaleff D (1981) Transposable elements (Ty) in yeast. Cold Spring Harb Symp Quant Biol 45:575–580

    CAS  PubMed  Google Scholar 

  • Geissler E (1983) Movable DNA elements and evolution. In: Geissler E, Scheler W (eds) Darwin today, Berlin (in press)

  • Geissler E, Scherneck S, Waehlte H, Zimmermann W, Luebbe L, Krause H, Theile M, Herold H-J, Rudolph M, Weickmann F, Nisch G (1980a) Further studies on the relationship of SV40-like viruses to human tumors. Cold Spring Harb Conf Cell Proliferation 7:343–356

    CAS  Google Scholar 

  • Geissler E, Scherneck S, Theile M, Herold H-J, Staneczek W, Zimmermann W, Krause H, Prokoph H, Vogel F, Platzer M (1980b) Studies on the mutagenic and transforming activities of SV40-like viruses. In: Bachmann PA (ed) Leukemias, lymphomas and papillomas: Comparative aspects. Taylor and Francis Ltd., London, pp 43–55

    Google Scholar 

  • Gershenson SM (1981) Mutagenic action of DNA, insertions, transpositions and gene instability. Proc 14th Internat Congr Genet, Moscow 1978, vol I, Book two. Mir Publishers, Moscow, pp 96–115

    Google Scholar 

  • Girardi AJ, Jensen FC, Koprowski H (1965) SV40-induced transformation of human diploid cells: crisis and recovery. J Cell Comp Physiol 65:69–84

    CAS  PubMed  Google Scholar 

  • Goldberg S, Defendi V (1979) Increased mutation rates in doubly viral transformed Chinese hamster cells. Somat Cell Genet 5:887–895

    CAS  PubMed  Google Scholar 

  • Golubovsky MD, Plus N (1982) Mutability studies in two Drosophila melanogaster isogenic stocks, endemic for C picornavirus and virusfree. Mutation Res 103:29–32

    CAS  PubMed  Google Scholar 

  • Graffi A, Schramm T, Graffi I, Bierwolf D, Bender E (1968) Virus-associated skin-tumors of the Syrian hamster: Preliminary note. J Nat Cancer Inst 40:867–873

    CAS  PubMed  Google Scholar 

  • Greenspan DS, Carroll RB (1981) Complex of simian virus 40 large tumor antigen and 48,000-dalton host tumor antigen. Proc Natl Acad Sci USA 78:105–109

    CAS  PubMed  PubMed Central  Google Scholar 

  • Greer H, Igo M, de Bruijn F (1981) Transposable elements involving the his4 region of yeast. Cold Spring Harb Symp Quant Biol 45:567–574

    CAS  PubMed  Google Scholar 

  • Harbers K, Jähner D, Jaenisch R (1981) Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 293:540–542

    CAS  PubMed  Google Scholar 

  • Harnden DG (1974) Viruses, chromosomes and tumors: The interaction between viruses and chromosomes. In: German J (ed) Chromosomes and cancer. J. Wiley and Sons, New York, pp 151–190

    Google Scholar 

  • Hayward WS, Neel BG, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475–480

    CAS  PubMed  Google Scholar 

  • Heddle JA, Arlett CF (1980) Untransformed xeroderma pigmentosum cells are not hypersensitive to sister-chromatide exchange production by ethyl methanesulphonate—Implications for the use of transformed cell lines and for the mechanism by which SCE arise. Mutation Res 72:119–125

    CAS  PubMed  Google Scholar 

  • Hirai K, Campbell G, Defendi V (1974a) Changes of regulation of host DNA synthesis and viral DNA integration in SV40-infected cells. Cold Spring Harb Conf Cell Proliferation 1:151–166

    CAS  Google Scholar 

  • Hirai K, Defendi V, Diamond L (1974b) Enhancement of simian virus 40 transformation and integration by 4-nitroquinoline 1-oxide. Cancer Res 34:3497–3500

    CAS  PubMed  Google Scholar 

  • Hiscott JB, Murphy D, Defendi V (1980) Amplification and rearrangement of integrated SV40 DNA sequences accompany the selection of anchorage independent transformed mouse cells. Cell 22:535–543

    CAS  PubMed  Google Scholar 

  • Hiscott JB, Murphy D, Defendi V (1981) Instability of integrated viral DNA in mouse cells transformed by simian virus 40. Proc Natl Acad Sci USA 78:1736–1740

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hoffman RM, Jacobsen SJ, Erbe RW (1979) Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation. Proc Natl Acad Sci USA 76:1313–1317

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hoffman RM, Jacobsen SJ (1980) Reversible growth arrest in simian virus 40-transformed human fibroblasts. Proc Natl Acad Sci USA 77:7306–7310

    CAS  PubMed  PubMed Central  Google Scholar 

  • Horan PK, Jett JH, Romero A, Lehman JM (1974) Flow microfluorometry analysis of DNA content in Chinese hamster cells following infection with simian virus 40. Int J Cancer 14:514–521

    CAS  PubMed  Google Scholar 

  • Howard BV, Estes MK, Pagano JS (1971) The upstake of SV40 DNA by nonpermissive cells in the presence of DEAE-dextran. Biochim Biophys Acta 228:105–116

    CAS  PubMed  Google Scholar 

  • Hughes SH, Payvar F, Spector DH, Schimke RT, Robinson HL, Bishop JM, Varmus HE (1979) Heterogeneity of genetic loci in chickens: Analysis of endogenous viral and non-viral genes by cleavage of DNA with restriction endonucleases. Cell 18:347–359

    CAS  PubMed  Google Scholar 

  • Hughes SH, Toyoshima K, Bishop JM, Varmus HE (1981) Organization of the endogenous proviruses of chickens: Implications for origin and expression. Virology 108:189–207

    CAS  PubMed  Google Scholar 

  • Ide T, Anzai K, Andoh T (1976) Enhancement of SV40 transformation by treatment of C3H2K cells with UV light and caffeine. II. The effects of multiplicity of infection, cell phase and time with caffeine. Virology 72:480–485

    CAS  PubMed  Google Scholar 

  • Ising G, Block K (1981) Derivation-dependent distribution of insertion sites for a Drosophila transposon. Cold Spring Harb Sym Quant Biol 45:527–544

    CAS  Google Scholar 

  • Jaenisch R, Nobis P, Jähner D, Stuhlmannn H (1980) Molecular parameters and immunotherapy of leukemia in BALB/Mo mice. In: Essex M, Todaro G, Zur Hausen H (eds) Viruses in naturally occurring cancers, Book B. Cold Spring Harb, NY, pp 1021–1032

    Google Scholar 

  • Jay G, DeLeo AB, Appella E, DuBois G, Law LW, Khoury G, Old LJ (1980) A common transformation-related protein in murine sarcomas and leukemias. Cold Spring Harb Symp Quant Biol 44:659–664

    CAS  PubMed  Google Scholar 

  • Jenkins NA, Copeland NG, Taylor BA, Lee BK (1981) Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293:370–374

    CAS  PubMed  Google Scholar 

  • Ju G, Boone L, Skalka A (1980) Isolation and characterization of recombinant DNA clones of avian retroviruses: Size heterogeneity and instability of the direct repeat. J Virol 33:1026–1033

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kaighn ME, Narayan KS, Ohnuki Y, Jones LW, Lechner JF (1980) Differential properties among clones of simian virus 40-transformed human epithelial cells. Carcinogenesis 1:635–645

    CAS  PubMed  Google Scholar 

  • Kleckner N (1981) Transposable elements in prokaryotes. Ann Rev Genet 15:341–404

    CAS  PubMed  Google Scholar 

  • Klein G (1981) The role of gene dosage and genetic transposition in carcinogenesis. Nature 294:313–318

    CAS  PubMed  Google Scholar 

  • Kuhlmann I, Achten S, Rudolph R, Doerfler W (1982) Tumor induction by human adenovirus type 12 in hamsters: loss of the viral genome from adenovirus type 12-induced tumor cells is compatible with tumor formation. THE EMBO J 1:79–86

    CAS  PubMed  Google Scholar 

  • Landy A, Ross W (1977) Viral integration and excision: Structure of the lambda att sites. Science 197:1147–1160

    CAS  PubMed  PubMed Central  Google Scholar 

  • Law MF, Lowy DR, Dvoretzky I, Howley PM (1981) Mouse cells transformed by Bovine papillomavirus contain only extrachromosomal viral DNA sequences. Proc Natl Acad Sci USA 78:2727–2731

    CAS  PubMed  PubMed Central  Google Scholar 

  • Leder A, Swan D, Ruddle F, D'Eustachio P, Leder P (1981) Dispersion of α-like globin genes of the mouse to three different chromosomes. Nature 293:196–200

    CAS  PubMed  Google Scholar 

  • Lehman JM (1974) Early chromosome changes in diploid Chinese hamster cells after infection with simian virus 40. Int J Cancer 13: 164–172

    CAS  PubMed  Google Scholar 

  • Lubiniecki AS, Blattner WA, Fraumeni JF (1977a) Elevated expression of T-antigen in simian papovavirus 40-infected skin fibroblasts from individuals with cytogenetic defects. Cancer Res 37:1580–1583

    CAS  PubMed  Google Scholar 

  • Lubiniecki AS, Blattner WA, Fraumeni JF (1977b) SV40 T antigen expression in skin fibroblasts from normal individuals, patients with Fanconi's anemia, and a family at high risk of leukemia. In: Mulvihill JJ, Miller RW, Fraumeni JF (eds) Genetics of human cancer. Raven Press, New York, pp 377–381

    Google Scholar 

  • Lubiniecki AS, Blattner WA, Martin GM, Fialkow PJ, Dosik H, Eatherly C, Fraumeni JF Jr (1979) SV40 T-antigen expression in cultured fibroblasts from patients with Donn syndrome and their parents. Am J Hum Genet 31:469–477

    CAS  PubMed  PubMed Central  Google Scholar 

  • Luebbe L, Strauss M, Geissler E (1979) Reversion of HGPRT deficiency of skin fibroblasts from Lesch-Nyhan patients. FEBS Proc Meet 56:67–78

    Google Scholar 

  • Luebbe L (1981) Untersuchung der SV40-induzierten Transformation und Reversion der HGPRT-Defizienz kultivierter Hautfibroblasten von Lesch-Nyhan-Patienten. Dissertation Academy of Sciences of the GRD, Berlin

  • Lukasch LL, Buzhievskaya TI, Varshaver NB, Shapiro NI (1981) Oncogenic adenovirus as mutagen for Chinese hamster cells in vitro. Somatic Cell Genet 7:133–146

    Google Scholar 

  • Majors JN, Swanstrom R, DeLorbe WJ, Payne GS, Hughes SH, Ortiz S, Quintrell N, Bishop JM, Varmus HE (1981) DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements. Cold Spring Harb Symp Quant Biol 45:731–738

    CAS  PubMed  Google Scholar 

  • Makino S (1975) Human chromosomes. Tokyo, pp 42–46, 356–386

  • Malz W, Koerner IJ, Theile M (1979) Mutation induction and repair processes in Chinese hamster V79/4 cells after SV40-infection. Stud Biophys 76:47–48

    Google Scholar 

  • Marengo C, Mbikay M, Weber J, Thirion J-P (1981) Adenovirus-induced mutations at the hypoxanthine-phosphoribosyltransferase locus of Chinese hamster cells. J Virol 38:184–190

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marshak MI, Varshaver NB, Shapiro NI (1973) Induction of gene mutations in cultured mammalian cells by the simian virus 40. Genetica (USSR) 9:138–141

    CAS  Google Scholar 

  • Marshak MI, Varshaver NB, Shapiro NI (1975) Induction of gene mutations and chromosomal aberrations by simian virus 40 in cultured mammalian cells. Mutation Res 30:383–396

    CAS  PubMed  Google Scholar 

  • Matthews REF (1979) Classification and nomenclature of viruses. S. Karger, Basel München Paris London New York Sydney

    Google Scholar 

  • McClements WL, Enquist LW, Oskarsson M, Sullivan M, Vande Woude GF (1980) Frequent site specific deletion of coliphage α murine sarcoma virus recombinants and its use in the identification of a retrovirus integration site. J Virol 35:488–497

    CAS  PubMed  PubMed Central  Google Scholar 

  • McClintock B (1951) Chromosome organisation and genic expression. Cold Spring Harb Symp Quant Biol 16:14–47

    Google Scholar 

  • Meuth M, L'Heureux-Huard N, Trudel M (1979) Characterization of a mutator gene in Chinese hamster ovary cells. Proc Natl Acad Sci USA 76:6505–6509

    CAS  PubMed  PubMed Central  Google Scholar 

  • Meuth M (1981) Sensitivity of a mutator gene in Chinese hamster ovary cells to deoxynucleoside triphosphate pool alterations. Molec and Cell Biol 1:652–660

    CAS  Google Scholar 

  • Milo GE, Blakeslee JR, Hart R, John DS (1978) Chemical carcinogen alteration of SV40 virus induced transformation of normal human cell populations in vitro. Chem-Biol Interactions 22:185–197

    CAS  Google Scholar 

  • Moar MH, Campo MS, Laird H, Jarrett WFH (1981) Persistence of non-integrated viral DNA in bovine cells transformed in vitro by bovine papillomavirus type 2. Nature 293:749–751

    CAS  PubMed  Google Scholar 

  • Neel BG, Hayward WS, Robinson HL, Fang J, Astrin SM (1981) Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion. Cell 23:323–334

    CAS  PubMed  Google Scholar 

  • Neel JV, Rothman E (1981) Is there a difference among human populations in the rate with which mutation produces electrophoretic variants? Proc Natl Acad Sci USA 78:3108–3112

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nichols WW (1974) Viruses and chromosomes. In: Busch H (ed) The cell nucleus, vol 2. Academic Press, New York, pp 437–458

    Google Scholar 

  • Nichols WW, Bradt CI, Toji LH, Godley M, Segawa M (1978) Induction of sister chromatid exchanges by transformation with simian virus 40. Cancer Res 38:960–964

    CAS  PubMed  Google Scholar 

  • Nichols WW, Toji LH, Dion AS (1981) Genetic effects of virus transformation. Proc 14th Internat Congr Genet Moscow 1978, vol II, Book one. Mir Publishers, Moscow, pp 258–263

    Google Scholar 

  • Nishiyama Y, Rapp F (1981) Enhanced capacity of DNA repair in human cytomegalovirus-infected cells. J Virol 38:164–172

    CAS  PubMed  PubMed Central  Google Scholar 

  • Paquin LA, Baumiller RC (1978) Sigma virus induced mutation in inversion entire X chromosome and in the second chromosome of Drosophila melanogaster. Abstracts XIV. Internat Congr of Genetics, Moscow, pt II, p 265

  • Perier F, Efstratiadis A, Lomedico P, Gilbert W, Kolodner R, Dodgson J (1980) The evolution of genes: the chicken preproinsulin gene. Cell 20:555–556

    Google Scholar 

  • Roeder GS, Fink G (1980) DNA rearrangements associated with a transposable element in yeast. Cell 21:239–249

    CAS  PubMed  Google Scholar 

  • Rubin GM, Brorein WJ Jr, Dunsmuir P, Flavell AJ, Levis R, Strobel E, Toole JJ, Young E (1981) copia-like transposable elements in Drosophila genome. Cold Spring Harb Symp Quant Biol 45:619–628

    CAS  PubMed  Google Scholar 

  • Sack GH (1981) Human cell transformation by simian virus 40—A review. in vitro 17:1–19

    CAS  PubMed  Google Scholar 

  • Sager R, Anisowiez A, Howell N (1981) Genomic rearrangements and tumor-forming potential in an SV40-transformed mouse cell line and its hybrid and cybrid progeny. Cold Spring Harb Symp Quant Biol 45:747–754

    CAS  PubMed  Google Scholar 

  • Sarasin A, Benoit A (1980) Induction of an error-prone mode of DNA repair in UV-irradiated monkey kidney cells. Mutation Res 70:71–81

    CAS  PubMed  Google Scholar 

  • Scherneck S, Luebbe L, Geissler E, Nisch G, Rudolph M, Waehlte H, Weickmann F, Zimmermann W (1979a) Detection of simian virus 40 related T-antigen in human meningiomas. Zbl Neurochir 40:121–130

    CAS  Google Scholar 

  • Scherneck S, Rudolph M, Geissler E, Vogel F, Luebbe L, Waehlte H, Nisch G, Weickmann F, Zimmermann W (1979b) Isolation of a SV40-like papovavirus from a human glioblastoma. Int J Cancer 24:523–531

    CAS  PubMed  Google Scholar 

  • Scherneck S, Boettger M, Feunteun J (1979c) Studies on the DNA of an oncogenic papovavirus of the Syrian hamster. Virology 96:100–107

    CAS  PubMed  Google Scholar 

  • Scherneck S, Vogel F, Boettger M (1980) Physical characterization of the genome of a papovavirus of the Syrian hamster. In: Zadrazil S, Sponar J (eds) DNA-recombinations, interactions and repair. Pergamon Press, Oxford New York, pp 181–190

    Google Scholar 

  • Scherneck S, Waehlte H, Theile M, Boettger M, von Mickwitz C-U, Geissler E (1982) In vitro transformation and mutation of Chinese hamster cells by different SV40 nucleoprotein complexes. Acta virol (in press)

  • Shanabruch WG, Behlau I, Walker GC (1981) Spontaneous mutators of Salmonella typhimurium LT2 generated by insertion of transposable elements. J Bact 147:827–835

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shapiro NI (1981) Viral mutagenesis in cultured mammalian somatic cells. Proc 14th Internat Congr Genet Moscow 1978, vol II, Book one. Mir publishers, Moscow, pp 220–228

    Google Scholar 

  • Siegel EC, Wain SL, Meltzer SF, Binion ML, Steinberg JL (1982) Mutator mutations in Escherichia coli induced by the insertion of phage Mu and the transposable resistance elements Tn5 and Tn10. Mutation Res 93:25–33

    CAS  PubMed  Google Scholar 

  • Siminovitch L (1976) On the nature of hereditable variation in cultured somatic cells. Cell 7:1–11

    CAS  PubMed  Google Scholar 

  • Starlinger P (1980) IS elements and transposons. Plasmid 3:241–259

    CAS  PubMed  Google Scholar 

  • Strauss M, Theile M, Eckert R, Geissler E (1978) Detection of antigenically active mutant HGPRT after mutagenesis with simian virus 40. Mutation Res 51:297–300

    CAS  PubMed  Google Scholar 

  • Strauss M, Luebbe L, Geissler E (1981) HGPRT structural gene mutation in Lesch-Nyhan syndrome as indicated by antigenic activity and reversion of the enzyme deficiency. Hum Genet 57:185–188

    CAS  PubMed  Google Scholar 

  • Tabuchi K, Kirsch WM, Low M, Graskin D, Van Buskirk J, Maa S (1978) Screening of human brain tumors for SV40-related T-antigen. Int J Cancer 21:12–17

    CAS  PubMed  Google Scholar 

  • Taylor AL (1963) Bacteriophage-induced mutation in Escherichia coli. Proc Natl Acad Sci USA 50:1043–1051

    CAS  PubMed  PubMed Central  Google Scholar 

  • Temin HM (1980a) Viral oncogenes. Cold Spring Harb Symp Quant Biol 44:1–7

    PubMed  Google Scholar 

  • Temin HM (1980b) Origin of retroviruses from cellular movable genetic elements. Cell 21:599–600

    CAS  PubMed  Google Scholar 

  • Theile M, Scherneck S (1978) Zellgenetik. Akademie-Verlag, Berlin

    Google Scholar 

  • Theile M, Scherneck S, Geissler E (1976) Mutagenesis by simian virus 40. I. Detection of mutations in Chinese hamster cell lines using different resistance markers. Mutation Res 37:111–124

    CAS  PubMed  Google Scholar 

  • Theile M, Scherneck D, Geissler E (1979a) Mutagenese durch Simian Virus 40. IV. Einfluß der Infektionsmultiplizität auf die Frequenz nachweisbarer Resistenzmutanten bei in vitro kultivierten Säugerzellen. Erg exp Med 34:55–62

    CAS  Google Scholar 

  • Theile M, Scherneck S, von Mickwitz C-U (1979b) Studies on resistance mutations in Chinese hamster cells induced by simian virus 40 and its DNA. Scripta medica (Brno) 52:53–54

    Google Scholar 

  • Theile M, Scherneck S, Geissler E (1980a) DNA of simian virus 40 mutates Chinese hamster cells. Arch Virol 55:293–309

    Google Scholar 

  • Theile M, Strauss M, Luebbe L, Scherneck S, Krause H, Geissler E (1980b) SV40-induced somatic mutations: Possible relevance to viral transformation. Cold Spring Harb Symp Quant Biol 44:377–382

    CAS  PubMed  Google Scholar 

  • Theile M, Strauss M (1977) Mutagenesis by simian virus 40. II. Changes in substrate affinities in mutant hypoxanthine-guanine phosphoribosyltransferase enzymes at different pH values. Mutation Res 45:111–123

    CAS  PubMed  Google Scholar 

  • Theile M, Krause H (1979) The combined mutagenic action of simian virus 40 and other carcinogens in Chinese hamster cells. Stud Biophys 76:45–46

    CAS  Google Scholar 

  • Theile M (1982) Mutagenesis in mammalian cells induced by oncogenic DNA viruses. Biol Zbl 101:321–348

    Google Scholar 

  • Theile M, Scherneck S, Waehlte H, Geissler E (1983) Are transforming and mutagenic activities of oncogenic papovaviruses correlated? Arch Geschwulstforsch (in press)

  • Tooze J (1980) DNA tumor viruses. Cold Spring Harbor Laboratory, New York

    Google Scholar 

  • Varmus HE, Quintrell N, Ortiz S (1981) Retroviruses as mutagens: Insertion and excision of a non-transforming provirus alter expression of a resident transforming provirus. Cell 25:23–36

    CAS  PubMed  Google Scholar 

  • Varshaver NB, Marshak MI, Luss EV, Gorbunova LV, Shapiro NI (1977) Spontaneous, chemical and viral mutagenesis in temperature-sensitive glutamine-requiring Chinese hamster cells. Mutation Res 43:263–278

    CAS  PubMed  Google Scholar 

  • Varshaver NB, Marshak MI, Gorbunova LV, Lukash LL, Shapiro NI (1980) The synergistic effects of SV40 and BUdR on induction of gene mutations and chromosomal aberrations in Chinese hamster cells. Mutation Res 70:351–364

    CAS  PubMed  Google Scholar 

  • Vogel F (1983) Discussion remark. In: Geissler E, Scheler W (eds) Darwin today. Berlin (in press)

  • Weinberg RA (1980) Integrated genomes of animal viruses. Ann Rev Biochem 49:197–226

    CAS  PubMed  Google Scholar 

  • Weiner LP, Herndon RM, Narayan O, Johnson RT, Shak K, Rubinstein LJ, Preziosi TJ, Conley FK (1972) Isolation of virus related to SV40 from patients with progressive multifocal leucoencephalopathy. N Engl J Med 280:385–390

    Google Scholar 

  • Weiss AF, Portmann R, Fischer H, Simon J, Zang KD (1975) Simian virus 40-related antigens in three human meningiomas with defined chromosome loss. Proc Natl Acad Sci USA 72:609–613

    CAS  PubMed  PubMed Central  Google Scholar 

  • Weiss RA, Teich NM, Varmus H, Coffin JM (eds) (1982) RNA tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

    Google Scholar 

  • Westphal H, Dulbecco R (1968) Viral DNA in polyoma-and SV40-transformed cell lines. Proc Natl Acad Sci USA 59:1158–1165

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wilson JH (1978) Interference in SV40 DNA infections: A possible basis for cellular competence. Virology 91:380–388

    CAS  PubMed  Google Scholar 

  • Wright JA, Lewis WH, Parfett CLJ (1980) Somatic cell genetics: A review of dry resistance, lectine resistance and gene transfer in mammalian cells in culture. Can J Genet Cytol 22:443–496

    CAS  PubMed  Google Scholar 

  • Wolff S, Rodin B, Cleaver JE (1977) Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cells. Nature 265:347–349

    CAS  PubMed  Google Scholar 

  • Zang KD, Weiss A, Zanke H (1976) Cytogenetic and immunological evidence for SV40-related papovaviruses in human meningiomas. Abstracts of Proc Vth Intern Congr Hum Genet, Mexico DF, 1976; Excerpta Medica Series No. 397, Amsterdam, p 170

  • Zang KD, May G, Fischer H (1979) Expression of SV40-related T-antigen in cell cultures of human meningiomas. Naturwissenschaften 66:59

    CAS  PubMed  Google Scholar 

  • Zasukhina GD, Sinelschikova TA, Vasilyeva IM, Kirkova ZS (1981) An approach to modification of the repair activity in eukaryotic cells by biological factors. Mutation Res 81:123–132

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Virologie, Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, Robert-Rössle-Str. 10, DDR-1115, Berlin-Buch, Germany

    Erhard Geissler & Michael Theile

Authors
  1. Erhard Geissler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael Theile
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Geissler, E., Theile, M. Virus-induced gene mutations of eukaryotic cells. Hum Genet 63, 1–12 (1983). https://doi.org/10.1007/BF00285389

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00285389

Keywords

Search

Navigation