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Orosomucoid (ORM) typing by isoelectric focusing: evidence for two structural loci ORM1 and ORM2

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Summary

Orosomucoid (ORM) phenotyping was performed by isoelectric focusing and immunoprinting. The band patterns of desialyzed ORM indicated that the ORM system is controlled by two structural loci ORM1 and ORM2. In a total of 253 samples from two Caucasoid populations, five phenotypes determined by three polymorphic alleles, ORM1 *1, ORM1 *2, and ORM1 *3 were identified. The ORM1 *3 was characteristic of the Caucasoids. The ORM2 locus was monomorphic.

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References

  • Berger EG, Wyss SR, Nimberg RB, Schmid K (1980) The microheterogeneity of human plasma α1-acid glycoprotein. Hoppe-Seylers Z Physiol Chem 361:1567–1572

    Google Scholar 

  • Cooper R, Papaconstantinou J (1986) Evidence for the existence of multiple α1-acid glycoprotein genes in the mouse. J Biol Chem 261:1849–1853

    Google Scholar 

  • Dente L, Ciliberto G, Cortese R (1985) Structure of the human α1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res 13:3941–3952

    Google Scholar 

  • Johnson AM, Schmid K, Alper CA (1969) Inheritance of human α1-acid glycoprotein (orosomucoid) variants. J Clin Invest 48:2293–2299

    Google Scholar 

  • Schmid K (1975) Variants of α1-acid glycoprotein. In: Putnam FW (ed) The plasma proteins, vol 1. Academic Press, New York London, pp 183–228

    Google Scholar 

  • Tokita K, Schmid K (1963) Variants of α1-Acid glycoprotein. Nature 200:266

    Google Scholar 

  • Umetsu K, Ikeda N, Kashimura S, Suzuki T (1985) Orosomucoid (ORM) typing by print lectinofixation: a new technique for isoelectric focusing. Two common alleles in Japan. Hum Genet 71:223–224

    Google Scholar 

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Authors and Affiliations

  1. Department of Legal Medicine, Tottori University School of Medicine, 683, Yonago, Japan

    I. Yuasa

  2. Department of Forensic Medicine, Yamagata University School of Medicine, 990-23, Yamagata, Japan

    K. Umetsu

  3. Yamaguchi Red Cross Hospital, 753, Yamaguchi, Japan

    K. Suenaga

  4. Centre de Transfusion Sanguine, Institut d'Hematologie, F-34010, Montpellier, France

    M. Robinet-Levy

Authors
  1. I. Yuasa
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  2. K. Umetsu
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  3. K. Suenaga
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  4. M. Robinet-Levy
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Yuasa, I., Umetsu, K., Suenaga, K. et al. Orosomucoid (ORM) typing by isoelectric focusing: evidence for two structural loci ORM1 and ORM2. Hum Genet 74, 160–161 (1986). https://doi.org/10.1007/BF00282080

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  • DOI: https://doi.org/10.1007/BF00282080

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