Summary
Cytogenetic studies of three Fanconi's anemia patients are reported, one of the patients having erythroleukemia, the other two preleukemia. Clonal abnormalities were present in all three cases. Partial chromosomal duplication uncommon in other leukemias was observed. Partial duplication of the long arm of chromosome 3 has been observed in the present case of erythroleukemia examined as well as in a previously reported one.
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References
Berger R, Bussel A, Schenmetzler C (1975) Anomalies chromosomiques et anémie de Fanconi. Etude de 4 cas. Nouv Rev Fr Hematol 15:539–550
Berger R, Bussel A, Schenmetzler C (1977) Somatic segregation and Fanconi anemia. Clin Genet 11:409–415
Bourgeois CA, Hill FGH (1977) Fanconi anemia leading to acute myelomonocytic leukemia. Cytogenetic studies Cancer 39: 1163–1167
Crossen PE, Mellor JEL, Adams AC, Gunz FW (1972) Chromosome studies in Fanconi's anaemia before and after treatment with oxymetholone. Pathology 4:27–33
Frocrain C, Tanzer J, Desmaret MC (1978) Preleukemic syndrome (“Belgian type”) in a patient with Fanconi's anemia. Symposium on Chromosomes et hémopathies, Poitiers
Hirschman RJ, Shulman NR, Abuelo JG, Whang-Peng J (1969) Chromosomal aberrations in two cases of inherited aplastic anemia with unusual clinical features. Ann Intern Med 71: 107–117
Lisker R, Cobo de Gutierrez A (1974) Cytogenetic studies in Fanconi's anemia. Description of a case with bone marrow clonal evolution. Clin Genet 5:72–76
Paris Conference. 1971 (1972) Standardization in Human Cytogenetics. Birth Defects: Orig Art Ser VIII: 7. The National Foundation, New York
Paris Conference, 1971; Supplement, 1975 (1975) Standardization in Human Cytogenetics. Birth Defects: Orig Art Ser XI:9. The National Foundation, New York
Perona G, Cetto GL, Bernadi F, Todeschini G, d'Andrea F (1977) Fanconi's anaemia in adults: study of three families. Haematologica (Pavia) 62:615–628
Schroeder TM, Drings P, Beilner P, Buchinger G (1977) Clinical and cytogenetic observations during a six-year period in an adult with Fanconi's anaemia. Blut 34:119–132
Schroeder TM, Pöhler E, Hufnagl HD, Stahl-Mauge C (1979) Fanconi's anemia: terminal leukemia and “forme fruste” in one family. Clin Genet 16:260–268
Von Koskull H, Aula P (1973) Nonrandom distribution of chromosome breaks in Fanconi's anaemia. Cytogenet Cell Genet 12:423–434
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Berger, R., Bernheim, A., Le Coniat, M. et al. Chromosomal studies of leukemic and preleukemic Fanconi's anemia patients. Hum Genet 56, 59–62 (1980). https://doi.org/10.1007/BF00281569
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DOI: https://doi.org/10.1007/BF00281569