Summary
The effect of peripheral nerve transection on the size of the microglial cell population in cytoarchitecturally distinct regions of the spinal cord dorsal horn of rats was evaluated at selected intervals 2 through 35 days after unilateral brachial plexotomy. The identification of cells was verified by electron microscopic examination of a representative random sample of cells included in the counts. Microglial cell numbers were increased in laminae I, II as well as the arbitrarily defined deeper laminae 3.5 days after surgery. Although microglial cell numbers in laminae I were within normal range 35 days after axotomy, those of the more ventrally located laminae remained significantly greater than control values for the duration of the experimental period. These findings demonstrate that: 1) microglial cell proliferation in the dorsal horn is an early event in the central changes that are attendant to peripheral nerve injury 2) the time course of the response varies in cytoarchitecturally different regions.
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Cova, J.L., Aldskogius, H., Arvidsson, J. et al. Changes in microglial cell numbers in the spinal cord dorsal horn following brachial plexus transection in the adult rat. Exp Brain Res 73, 61–68 (1988). https://doi.org/10.1007/BF00279661
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DOI: https://doi.org/10.1007/BF00279661