Summary
Banded chromosomes of leukemic cells were studied in 53 children with chronic myeloid leukemia (CML). Ph1 chromosome was found in 21 children, and the remaining 32 cases were Ph1 negative. Besides Ph1 translocation additional chromosomal abnormalities, including marker i(17q), were revealed in three of eight children studied in blastic crisis of Ph1 positive CML.
Leukemic cells of most patients with Ph1 negative CML possessed normal karyotype. Clones with chromosomal abnormalities were found in 12 of 32 cases. Most characteristic were monosomy 7 (in four children) and trisomy 8 (in three). Abnormal karyotype may be a bad prognostic sign in Ph1 negative CML. The presented data confirm the difference in age of appearance, bone marrow pattern and clinical course between Ph1 positive (“adult”) and Ph1 negative (juvenile) types of CML in children. Probable prenatal commencement of CML in babies and children in the first years of life is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Altman AJ, Palmer CG, Baehner RL (1974) Juvenile “chronic granulocytic” leukemia: a panmyelopathy with prominent monocytic involvement and circulating monocyte colony-forming cells. Blood 43:341–350
Astaldi G, Mauri C (1953) Recherches sur l'activité proliferative de l'hemocytoblaste de la leucémie aigue. Rev Belge Pathol Med Exp 23:70–82
Berghe van den H, David G, Michaux J-L, Sokal G (1979) Non-random chromosome anomalies in human myeloproliferative disorders. Cancer Detect Prevent 2:113–123
Borgström GH, Teerenhovi L, Vuopio P, de la Chapelle A, van den Berghe H, Brandt L, Golomb HM, Louwagie A, Mitelman F, Rowley JD, Sandberg AA (1980) Clinical implications of monosomy 7 in acute nonlymphocytic leukaemia. Cancer Genet Cytogenet 2: 115–126
Brodeur GM, Dow LW, Williams DL (1979) Cytogenetic features of juvenile chronic myelogenous leukemia. Blood 53:812–819
Casalone R, Francesconi D, Pasquali F, Comotty B, Vaccari F (1981) Isochromosome (17q) in Philadelphia chromosome (Ph1)—negative juvenile chronic myelocytic leukemia. Cancer Genet Cytogenet 3: 145–148
Clarkson BD (1969) Review of recent studies of cellular proliferation in acute leukemia. In: Human tumor cell kinetics. Natl Cancer Inst Monogr 30:81–120
Clarkson BD (1981) The elusive goal: Presidential address. Cancer Res 41:4865–4884
Fleischman EW, Prigogina EL, Volkova MA, Frenkel MA, Zakhartchenko NA, Konstantinova LN, Puchkova GP, Balakirev SA (1981) Correlations between the clinical course, characteristic of blast cells, and karyotype patterns in chronic myeloid leukemia. Hum Genet 58:285–293
Hardisty RM, Speed DE, Till M (1964) Granulocytic leukemia in childhood. Br J Haematol 10:551–556
Hays T, Morse H, Peakman D, Rose B, Robinson A (1979) Cytogenetic studies of chronic myelocytic leukemia in children and adolescents. Cancer 44:210–214
Inoue S, Ravindranath Y, Thompson RI, Zuelzer NW, Ottenbreit MJ (1977) Cytogenetics of juvenile type chronic granulocytic leukemia. Cancer 39:2017–2024
ISCN (1978) An international system for human cytogenetic nomenclature (1978). Cytogenet Cell Genet 21:309–404
Kamada N, Uchino N (1978) Chronologic sequence in appearance of clinical and laboratory findings characteristic of chronic myelocytic leukemia. Blood 51:843–850
Prigogina EL, Fleischman EW, Volkova MA, Frenkel MA (1978) Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia. Hum Genet 41:143–156
Sandberg AA (1980) The chromosomes in human cancer and leukemia. Elsevier, New York Amsterdam
Sieff CA, Chessells JM, Harvey BAM, Pickthall VJ, Lawler SD (1981) Monosomy 7 in childhood: a myeloproliferative disorder. Br J Haematol 49:235–249
Smith KL, Johnson WW (1974) Classification of chronic myelocytic leukemia in children. Cancer 34:670–679
Srivastava AK, Gruppo RA, Siegrist CW (1981) Chromosomal anomaly of 6q in chronic myelogenous leukemia (CML). Cancer Genet Cytogenet 3:131–136
Symann M, de Montpellier C, Ninane J, van Den Berge H (1982) “Spontaneous” erythroid progenitor cells in the circulation and monosomy 7 in juvenile chronic myelogenous leukemia. Cancer Genet Cytogenet 6:183–185
Warburton D, Shah N (1976) A 9/11 translocation in a child with Ph1-negative chronic myelogenous leukemia. J Pediatr 38:599–602
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Puchkova, G.P., Prigogina, E.L., Fleischmann, E.W. et al. Chromosome abnormalities in chronic myeloid leukemia in children. Hum Genet 64, 257–262 (1983). https://doi.org/10.1007/BF00279405
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00279405