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Variant chromosome 3 (inv3) in normal newborns and their parents, and in children with mental retardation

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Summary

The chromosomes of 102 normal newborn babies (51 boys and 51 girls) born at term, their parents, and 45 nonrelated children with mental retardation at the level of imbecility were investigated by fluorescence microscopy using propyl quinacrine mustard. In each of the 11 families, one of the parents had a variant chromosome 3 that was interpreted as resulting from a pericentric inversion of the brilliant band (or C band) only (inv3). In four cases inv3 was transmitted to the child. The frequency of inv3 in newborn boys and girls was 2 and 6% respectively, and in adult men and women 5 and 6% respectively. In children with mental retardation of unknown etiology the inv3 was detected in five cases (11.1%). This difference from normal persons was not significant.

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References

  • Arrighi, F. E., Hsu, T. C.: Localization of heterochromatin in human chromosomes. Cytogenetics 10, 81–86 (1971)

    Google Scholar 

  • Geraedts, J. P. M., Pearson, P. L.: Fluorescent chromosome polymorphisms: Frequencies and segregations in a Dutch population. Clin. Genet. 6, 247–258 (1974)

    Google Scholar 

  • Mellman, W. J.: Human peripheral blood leucocyte cultures: In: Human chromosome methodology, J. J. Yunis, ed. New York-London: Academic Press 1965

    Google Scholar 

  • Schwarzacher, H. G.: Fluorescence microscopy of chromosomes and interphase nuclei. In: Methods in human cytogenetics, H. G. Schwarzacher, U. Wolf, eds. Berlin-Heidelberg-New York: Springer 1974

    Google Scholar 

  • Soudek, D., O'Shaughnesky, S., Laraya, P., McCreary, B. D.: Pericentric inversion of “fluorescent” segment in chromosome No. 3. Humangenetik 22, 343–346 (1974)

    Google Scholar 

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Authors and Affiliations

  1. Genetic Unit of Central Medical Research Laboratory of Tartu State University, 202400, Tartu, Estonia, USSR

    A. -V. Mikelsaar, Tiiu Ilus & Sirje Kivi

  2. Laboratory of Medical Genetics of Tartu Republican Clinical Hospital, 202400, Tartu, Estonia, USSR

    A. -V. Mikelsaar, Tiiu Ilus & Sirje Kivi

Authors
  1. A. -V. Mikelsaar
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  2. Tiiu Ilus
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  3. Sirje Kivi
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Mikelsaar, A.V., Ilus, T. & Kivi, S. Variant chromosome 3 (inv3) in normal newborns and their parents, and in children with mental retardation. Hum Genet 41, 109–113 (1978). https://doi.org/10.1007/BF00278877

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  • DOI: https://doi.org/10.1007/BF00278877

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