Skip to main content
SpringerLink
Log in

An increased frequency of chromosomal changes and SCE's in cultured blood lymphocytes of 12 subjects vaccinated against smallpox

  • Short Communications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

An increased frequency of chromosomal changes and sister chromatid exchanges was detected in 10 women 7 days after smallpox vaccination.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Baldauf, W., Stenglein, B., Unglaub-Leisten, I., Bulheller, H., Stickl, H.: Chromosomenveränderungen an menschlichen Lymphocyten in vivo und in vitro durch Vaccinia-Virus. Klin. Wochenschr. 49, 260–263 (1971)

    Google Scholar 

  • Brown, R. L., Crossen, P. E.: Increased incidence of sister chromatid exchanges in Rauscher leukaemia virus infected mouse embryo fibroblasts. Exp. Cell Res. 103, 418–420 (1976)

    Google Scholar 

  • Changanti, R. S. K., Schonberg, S., German, J.: A many-fold increase, in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. (USA) 71, 4508–4512 (1974)

    Google Scholar 

  • Crossen, P. E., Drets, M. E., Arrighi, F. E., Johnston, D. A.: Analysis of the frequency and distribution of sister chromatid exchanges in cultured human lymphocytes. Hum. Genet. 35, 345–352 (1977)

    Google Scholar 

  • Galloway, S. M., Evans, H. J.: Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia. Cytogenet. Cell Genet. 15, 17–29 (1975)

    Google Scholar 

  • Hertzberg-Kremmer, H., Hertzberg, K.: Untersuchungen über postvakzinale Enzephalitis. Verhalten des Vakzinevirus im Menschen bei normalem und gestörtem Impfverlauf. Zbl. Bakt., I. Abt. Orig. 115, 271 (1930)

    Google Scholar 

  • Latt, S. A.: Localization of sister chromatid exchanges in human chromosomes. Science 185, 74–76 (1974)

    Google Scholar 

  • Mikhailova, G. R., Gorshunova, L. P., Tcherkezia, S. E.: Chromosomal aberration in the bone marrow cells in mice immunized with vaccinia, virus. Tsitologia 16, 1289–1295 (1974)

    Google Scholar 

  • Schuler, D., Hervei, S., Gács, G., Kirchner, M., Szathmary, J.: Einfluß von Pockenimpfviren, auf menschliche Chromosomen in vivo und in vitro. Humangenetik 6, 55–60 (1968)

    Google Scholar 

  • Shiraishi, Y., Freeman, A. I., Sandberg, A. A.: Increased sister chromatid exchange in bone marrow and blood cells from Bloom's syndrome. Cytogenet. Cell Genet 17, 162–173 (1976)

    Google Scholar 

  • Sperling, K., Wegner, R. D., Riehm, H., Obe, G.: Frequency and distribution of sister chromatid exchanges in a case of Fanconi's anemia. Humangenetik 27, 227–230 (1975)

    Google Scholar 

  • Zur Hausen, H., Lanz, E.: Chromosomale Aberrationen bei L-Zellen nach Vaccinia-Virus-Infektion. Z. Med. Mikrobiol. Immunol. 152, 60–65 (1966)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Department, Rinnekoti Institution for Mentally Retarded, Espoo 98, Finland

    Sakari Knuutila & Jorma Mäki-Paakkanen

  2. Department of Genetics, University of Helsinki, Finland

    Marketta Kähkönen

  3. The Medical Care Center of Laukaa, Finland

    Eeva Hokkanen

Authors
  1. Sakari Knuutila
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jorma Mäki-Paakkanen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marketta Kähkönen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eeva Hokkanen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Knuutila, S., Mäki-Paakkanen, J., Kähkönen, M. et al. An increased frequency of chromosomal changes and SCE's in cultured blood lymphocytes of 12 subjects vaccinated against smallpox. Hum Genet 41, 89–96 (1978). https://doi.org/10.1007/BF00278874

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278874

Keywords

Search

Navigation