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Identification of the origin of triploidy by HLA markers

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Summary

HLA-A and HLA-B markers have been determined in fibroblasts grown from tissues of triploid conceptuses and have been tested in the parents. Informative data on the origin of triploidy were obtained in eight cases: diandry I or dispermy in 4 cases, diandry II or dispermy in 2, digyny I or II in 2. This confirms that triploidy involved more frequently two sets of paternal chromosomes.

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References

  • Beatty, R. A.: Genetic aspects of spermatozoa. In: Physiology and genetics of reproduction, E. M. Coutinho, F. Fuchs, eds. pp. 183–196. New York: Plenum 1974

    Google Scholar 

  • Bisson, J. P., David, G., Kolevski, P., Hors, J., Dausset, J.: Azoospermy and HLA antigens. HLA and diseases. INSERM 58, 242 (1976)

    Google Scholar 

  • Blackwell, N. L., Keeling, J. W., Lindenbaum, H.: Dispermic origin of a 69, XXY triploid. Hum. Genet. 37, 121–124 (1977)

    Google Scholar 

  • Boué, A., Boué, J.: Chromosome abnormalities and abortion. In: Physiology and genetics of reproduction, E. M. Coutinbo, F. Fuchs, eds., Part B, pp. 317–399. New York: Plenum 1974

    Google Scholar 

  • Boué, A., Boué, J., Cure, S., Dèluchat, C., Perraudin, N.: In vitro cultivation of cells from aneuploid human embryos. Initiation of cell lines and longevity of the cultures. In vitro 11, 409–413 (1975)

    Google Scholar 

  • Boué, J., Boué, A.: Anomalies chromosomiques dans les avortements spontanés. In: Symposium on chromosomal errors in relation to reproductive failure, A. Boué, C. Thibault, eds., p. 29. Paris: INSERM 1973

    Google Scholar 

  • Boué, J., Boué, A., Lazar, P.: Les aberrations chromosomiques dans les avortements. Ann. Genet. 10, 179–187 (1967)

    Google Scholar 

  • Boué, J., Philippe, E., Giroud, A., Boué, A.: Phenotypic expression of lethal chromosomal anomalies in human abortuses. Teratology 14, 3–20 (1976)

    Google Scholar 

  • Brantbar, C., Puyne, R., Hayflick, L.: Fate of HLA antigens in aging cultured human diploid cell strains. Exp. Cell Res. 75, 31–38 (1972)

    Google Scholar 

  • Brown, S. W., Chandra, H. S.: Inactivation system of the mammalian X chromosome. Proc. Natl. Acad. Sci. (USA) 70, 195–199 (1973)

    Google Scholar 

  • Couillin, P., Boué, A., Boué, J., Ravise, N., Feingold, N., Hors, J.: HLA markers in parents of triploid conceptuses (in press, 1977)

  • Creasy, M. R., Crolla, J. A., Alberman, E. D.: A cytogenetic study of human spontaneous abortions using banding techniques. Hum. Genet. 31, 177–196 (1976)

    Google Scholar 

  • Cure, S., Boué, J., Boué, A.: Growth characteristics of human embryonic cell lines with chromosomal anomalies. Biomedicine 21, 233–236 (1974)

    Google Scholar 

  • Dao, V. L., Hors, J., Sasportes, M., Netter, R., Colombani, J.: HLA markers on human diploid skin fibroblast. Biol. Standardization 2, 121–128 (1974)

    Google Scholar 

  • Edwards, J. H., Yuncken, C., Rushton, D. I., Richards, S., Mittwoch, U.: Three cases of triploidy in man. Cytogenetics 6, 81–104 (1967)

    Google Scholar 

  • Fellous, M., Dausset, J.: Probable haploid expression of HLA antigens on human spermatozoa. Nature 225, 191–193 (1970)

    Google Scholar 

  • Francke, U., Pellegrino, M. A.: Assignment of the major histocompatibility complex to a region of the short arms of human chromosome 6. Proc. Natl. Acad. Sci. (USA) 74, 1147–1151 (1977)

    Google Scholar 

  • Jacobs, P. A., Morton, N. E.: Origin of human trisomies and polyploidies. Hum. Hered. 27, 59–72 (1977)

    Google Scholar 

  • Kajii, T., Niikawa, N.: Origin of triploidy and tetraploidy in man: 11 cases with chromosome markers. Cytogenet. Cell Genet. 18, 109–125 (1977)

    Google Scholar 

  • Kunze, J., Oldigs, H. D., Tolksdorf, M.: Identification of the triploid genome by the C-banding method. Europ. J. Pediat. 123, 111–114 (1976)

    Google Scholar 

  • Lauritsen, J. G.: Aetiology of spontaneous abortuses. Acta. Obstet. Gynec. Scand. Suppl. 52, 2 (1976)

    Google Scholar 

  • Mittal, K. K., Mickey, H. R., Songal, D. P., Terasaki, P.: Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 6, 913 (1968)

    Google Scholar 

  • Niebuhr, E.: Triploidy in man: Cytogenetical and clinical aspects. Humangenetik 21, 103–125 (1974)

    Google Scholar 

  • Niikawa, N., Kajii, T.: A triploid human abortus due to dispermy. Humangenetik 24, 261–264 (1974)

    Google Scholar 

  • Reid, D. E., Ryan, K. S., Benirschke, K.: Principles and management of human reproduction, p. 255. Philadelphia-London-Toronto: Saunders 1972

    Google Scholar 

  • Sasportes, M., Dehay, C., Fellous, M.: Variations of the expression of HLA antigens on human diploid fibroblasts in vitro. Nature 233, 332–334 (1971)

    Google Scholar 

  • Schindler, A. M., Mikamo, K.: Triploidy in man: report of a case and discussion on etiology. Cytogenetics 9, 116–130 (1970)

    Google Scholar 

  • Schingel, A., Hayashi, K., Schmid, W., Knecht, B., Tuschy, G., Boltshauser E.: Triploidie als Ursache von Schwangerschaftsgestose im 2. Trimenon. Arch. Gynäk. 218, 113–123 (1975)

    Google Scholar 

  • Terasaki, P. J., Mickey, M. R., Yamazaki, J. N., Vrederove, D.: Maternal—fetal incompatibility. Transplantation 9, 538–543 (1970)

    Google Scholar 

  • Therkelsen, A. J., Grunnet, N., Hjort, T., Jensen, O. M., Jonasson, J., Lauritsen, J. G., Lindsten, J., Petersen, G. B.: Studies on spontaneous abortions. In: Chromosome errors in relation to reproductive failure, A. Boué, C. Thibault, eds., pp. 81–93. Paris: INSERM 1974

    Google Scholar 

  • Uchida, I. A., Lin, C. C.: Identification of triploid genome by fluorescence microscopy. Science 176, 304–305 (1972)

    Google Scholar 

  • Wertelecki, W., Graham, J. M., Sergovich, F. R.: The clinical syndrome of triploidy. Obstet. Gynec. 47, 69–76 (1976)

    Google Scholar 

  • Yanagimachi, R.: Behavior and functions of the structural element of the mammalian sperm head in fertilization. In: Regulation of mammalian reproduction, S. Segal, ed., pp. 215–230. Springfield: Thomas 1973

    Google Scholar 

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Couillin, P., Hors, J., Boué, J. et al. Identification of the origin of triploidy by HLA markers. Hum Genet 41, 35–44 (1978). https://doi.org/10.1007/BF00278869

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