Summary
A sample of healthy unrelated individuals (882 from Continental Italy and Sicily, and 139 from Sardinia) were typed for HLA and Bf polymorphisms. Bf gene frequencies in Continental Italy and Sicily show an intermediate position among European populations, with Lapps on one side and Basques on the other side; while a very peculiar pattern is observed among Sardinians, with an impressive similarity with French Basques and with the highest F1 gene frequency so far observed. The HLA: Bf gametic associations in Italy and Sardinia are also reported, which confirm the different ethnic background of these populations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allen FH Jr (1974) Linkage of HLA and GBG. Vox Sang 27:382–384
Alper CA, Boenisch T, Watson L (1972) Genetic polymorphism in human glycine-rich β-glycoprotein. J Exp Med 135:68–80
Bargagna M, Benciolini P, Breda F, Cortivo P, Domenici R, Jayakar S, Pecori F, Piazza A (1979) Rapporto sulla distribuzione delle frequenze geniche dei principali marcatori genetici del sangue e sul loro uso per il calcolo delle probabilità di paternità. Riv It Med Leg 4:535–566
Barreca F (1974) La Sardegna fenicia e punica. Chiarella, Sassari
Bender K, Mayerová A, Frank R, Hiller C, Wienker T (1977) Haplotype analysis of the linkage group HLA-A:HLA-B:Bf and its bearing on the interpretation of the linkage disequilibrium. Hum Genet 36:191–196
Cavalli-Sforza LL, Bodmer WF (1971) The genetics of human populations. Freeman and Co, San Francisco, p 704
Dausset J, Legrand L, Lepage V, Contu L, Marcelli Barge A, Wildloecher I, Benajam A, Meo T, Degos L (1978) A haplotype study of HLA complex with special reference to the HLA-DR series and to Bf.C2 and glyoxalase I polymorphisms. Tissue Antigens 12: 297–307
Hauptmann G, Tongio MM, Mayer S (1977) La liaison génétique HLA-complément. Rev Fr Transfus Immunohématol 20:19–22
Jones EA, Goodfellow PN, Bodmer JG, Bodmer WF (1975) Serological identification of HLA-linked human “la-type” antigens. Nature 256:650–652
Lachmann PJ, Hobart MJ (1978) Complement genetics in relation to HLA. Br Med Bull 34:247–252
Malavasi F, Olivetti E (1981) Il polimorfismo del fattore B della Properdina nelle regioni italiane. La Trasfusione del Sangue (to be published)
Mattiuz PL, Ihde D, Piazza A, Ceppellini R, Bodmer WD (1970) New approaches to the population genetic and segregation analysis of the HL-A system. In: Terasaki PI (ed) Histocompatibility testing. Munksgaard, Copenhagen, p 193
Mauff G, Hauptmann G, Hitzeroth HW, Gauschel F, Scherz R (1978) The nomenclature of properdin factor B allotypes. Z Immunitaets-forsch Immunobiol 154:115–120
Menozzi P, Piazza A, Cavalli-Sforza L (1978) Synthetic maps of human gene frequencies in Europeans. Science 201:786–792
Mourant AE, Kopec AC, Domaniewska-Sobczak K (1976) The distribution of the human blood groups and other polymorphisms. Oxford University Press, London
Ohayon E, deMouzon A, Hauptmann G, Klein J, Ducos J (1980a) Genetic linkage between BfS0.7 (BfS1) and HLA-Bw50. Hum Genet 54:417–418
Ohayon E, deMouzon A, Hauptmann G, Klein J, Aabbal M, Constans J, Mayer S, Ducos J (1980b) High frequency of the properdin factor BfF1 and its linkage to HLA in French Basques. J Immunogenet 7:441–445
Olivetti E, Crepaldi T, Borelli I, Richiardi P, Curtoni ES (1980) Analisi di un campione della popolazione italiana per gli antigeni HLA-DR. Frequence geniche ed associazioni gametiche. G Batteriol Virol Immunol 73:7–12
Piazza A, Belvedere MC, Bernoco D, Conighi C, Contu L, Curtni ES, Mattiuz PL, Mayr W, Richiardi P, Scudeller G, Ceppellini R (1973) HL-A variation in four Sardinian villages under differential selective pressure by malaria. In: Dausset J, Colombani J (eds) Histocompatibility testing 1972. Munksgaard, Copenhagen, p 73
Piazza A, Menozzi P, Cavalli-Sforza L (1980) The HLA-A, B gene frequencies in the world: migration or selection? Hum Immunol 4:297–304
Püschel K, Schmidt M, Söder R, Brinkmann B (1979) Population genetic data on properdin factor B (Bf) in Northern Germany. Am J Phys Anthropol 50:247–250
Ryder LP, Andersen E, Svejgaard A (1978) An HLA map of Europe. Hum Hered 28:171–200
Rodriguez de Córdoba S, Bootello A, Arnaiz-Villen A (1981) Bf polymorphism and its relationship with HLA antigens in a sample of Spanish population: high BfF1 frequencies. TissueAntigens 2:231–237
Scherz R, Pflugshaupt R, Büttler R (1977) Genetic polymorphism of glycine-rich β-glycoprotein in the Swiss and Italian populations. Hum Hered 27:143–146
Scherz R, Pflugshaupt R, Büttler R, Peyretti F (to be published) Genetic polymorphism of glycine-rich beta-glycoprotein in the Italian population. Hum Hered
Stewart GJ, Cann HM, Grumet FC, Hay J, Kirk RL, Payne R (1980) Linkage disequilibrium between HLA-B and the rarer properdin factor B alleles, BfF1 and BfS1. Hum Immunol 1:31–36
Teisberg P, Olaisen B (1977) Properdin factor B (Bf) in Norway. Vox Sang 32:52–55
Terasaki PI, McClelland JD (1964) Microdroplet assay for human serum cytotoxins. Nature 204:998–1007
Author information
Authors and Affiliations
Additional information
This work was supported by Centro di Immunogenetica ed Istocompatibilità, C.N.R., Torino, Italy and by a grant of Ministero Pubblica Istruzione (M.P.I., Cap. 8551/1980).
Rights and permissions
About this article
Cite this article
Malavasi, F., Olivetti, E., Milanese, C. et al. Properdin factor B polymorphism in continental Italy and Sardinia. Hum Genet 58, 209–212 (1981). https://doi.org/10.1007/BF00278713
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00278713