Abstract
A model for the growth of a size-structured cell population reproducing by fission into two identical daughters is formulated and analysed. The model takes the form of a linear first order partial differential equation (balance law) in which one term has a transformed argument. Using semigroup theory and compactness arguments we establish the existence of a stable size distribution under a certain condition on the growth rate of the individuals. An example shows that one cannot dispense with this condition.
Similar content being viewed by others
References
Anderson, E. C., Bell, G. I., Peterson, D. F., Tobey, R. A.: Cell growth and division. IV. Determination of volume growth rate and division probability. Biophys. J. 9, 246–263 (1969)
Bell, G. I., Anderson, E. C.: Cell growth and division. I. A mathematical model with applications to cell volume distributions in mammalian suspension cultures. Biophys. J. 7, 329–351 (1967)
Bell, G. I.: Cell growth and division. III. Conditions for balanced exponential growth in a mathematical model. Biophys. J. 8, 431–444 (1968)
Diekmann, O., Lauwerier, H. A., Aldenberg, T., Metz, J. A. J.: Growth, fission and the stable size distribution. J. Math. Biol. 18, 135–148 (1983)
Feller, W.: An introduction to probability theory and its applications, vol. II. New York: Wiley 1966–1971
Fredrickson, A. G., Ramkrishna, D., Tsuchiya, H. M.: Statistics and dynamics of procaryotic cell populations. Math. Biosc. 1, 327–374 (1967)
Gyllenberg, M.: Nonlinear age-dependent population dynamics in continuously propagated bacterial cultures. Math. Biosc. 62, 45–74 (1982)
Hale, J. K.: Theory of functional differential equations. Berlin-Heidelberg-New York: Springer 1977
Heijmans, H. J. A. M.: An eigenvalue problem related to cell growth, preprint TW229 (1982) Mathematisch Centrum, Amsterdam, to appear in J. Math. Anal. Appl.
Heijmans, H. J. A. M.: On the stable size distribution of populations reproducing by fission into two unequal parts. In preparation
Hoppensteadt, F.: Mathematical theories of populations: Demographics, genetics and epidemics, SIAM, 1975
Keyfitz, N.: Introduction to the mathematics of population. Addison-Wesley, 1968
Ladas, G. E., Lakshmikantham, V.: Differential equations in abstract spaces. Academic Press 1972
Nisbet, R. M., Gurney, W. S. C.: The systematic formulation of population models for insects with dynamically varying instar duration. Theoret. Population Biology 23, 114–135 (1983)
Nussbaum, R. D.: The radius of the essential spectrum. Duke Math. J. 37, 473–488 (1970)
Pazy, A.: Semi-groups of linear operators and applications to partial differential equations. Berlin-Heidelberg-New York: Springer 1983
Rubinow, S. I.: Age-structured equations in the theory of cell populations. In: Studies in Math. Biol. (Levin, S. A., ed.) MAA Studies in Math. 16, 389–410 (1978)
Sinko, J. W., Streifer, W.: A new model for age-size structure of a population. Ecology 48, 910–918 (1967)
Sinko, J. W., Streifer, W.: A model for populations reproducing by fission. Ecology 52, 330–335 (1971)
Sudbury, A.: The expected population size in a cell-size dependent branching process. J. Appl. Prob. 18, 65–75 (1981)
Greiner, G.: Zur Perron-Frobenius theorie stark stetiger halbgruppen. Math. Z. 177, 401–423 (1981)
Greiner, G., Voigt, J., Wolff, M.: On the spectral bound of the generator of semigroups of positive operators. J. Operator Theory 5, 245–256 (1981)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Diekmann, O., Heijmans, H.J.A.M. & Thieme, H.R. On the stability of the cell size distribution. J. Math. Biology 19, 227–248 (1984). https://doi.org/10.1007/BF00277748
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00277748