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Lipoteichoic acid and lipids in the membrane of Staphylococcus aureus

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References

  1. Alkan ML, Beachy EM (1978) Excretion of lipoteichoic acid by group A streptococci: influence of penicillin on excretion and loss of ability to adhere to human oral mucosal cells. J Clin Invest 61:671–677

    Google Scholar 

  2. Archibald AR, Baddiley J, Heptinstall S (1973) The alanine ester content and magnesium binding capacity of walls of Staphylococcus aureus H, grown at different pH values. Biochim Biophys Acta 291:629–634

    Google Scholar 

  3. Baddiley J (1985) Trans-membrane synthesis of cell wall polymers. Biochem Soc Trans 13:992–994

    Google Scholar 

  4. Bhakdi S, Klonisch T, Nuber P, Fischer W (1991) Stimulation of monokine production by lipoteichoic acids. Infect Immun 59:4614–4620

    Google Scholar 

  5. Bierbaum G, Sahl H-G (1991) Induction of autolysis of Staphylococcus simulans 22 by Pep5 and nisin and influence of the cationic peptides on the activity of the autolytic enzymes. In: Jung G, Sahl H-G (eds) Nisin and novel lantibiotics. ESCOM, Leiden, pp 386–396

    Google Scholar 

  6. Boaretti M, Canepari P, Lleò MM, Satta G (1993) The activity of daptomycin on Enterococcus faecium protoplasts: indirect evidence supporting a novel mode of action on lipoteichoic acid synthesis. J Antimicrob Chemother 31:227–235

    Google Scholar 

  7. Bracha R, Chang M, Fiedler F, Glaser L (1978) Biosynthesis of teichoic acids. Methods Enzymol 50:387–402

    Google Scholar 

  8. Brade L, Brade H, Fischer W (1990) A 28 kDa protein of normal mouse serum binds lipopolysaccharides of Gram-negative and lipoteichoic acids of Gram-positive bacteria. Microb Pathog 9:355–362

    Google Scholar 

  9. Canepari P, Boaretti M, Lleò MM, Satta G (1990) Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY 146032). Antimicrob Agents Chemother 34:1220–1226

    Google Scholar 

  10. Chatterjee AN, Mirelman D, Singer HJ, Park JT (1969) Properties of a novel pleiotropic bacteriophage resistent mutant of Staphylococcus aureus H. J Bacteriol 100:846–853

    Google Scholar 

  11. Cleveland RF, Höltje JV, Wicken AJ, Tomasz A, Daneo-More L, Shockman GD (1975) Inhibition of bacterial wall lysins by lipoteichoic acids and related compounds. Biochem Biophys Res Commun 67:1128–1135

    Google Scholar 

  12. Coley J, Tarelli E, Archibald AR, Baddiley J (1978) The linkage between teichoic acid and peptidoglycan in bacterial cell walls. FEBS Lett 88:1–9

    Google Scholar 

  13. Courtney HS, Simpson WA, Beachy EH (1986) Relationship of critical micelle concentrations of bacterial lipoteichoic acids to biological activities. Infect Immun 51:414–418

    Google Scholar 

  14. Duckworth M, Archibald AR, Baddiley J (1975) Lipoteichoic acid and lipoteichoic acid carrier in Staphylococcus aureus H. FEBS Lett 53:176–179

    Google Scholar 

  15. Eliopoulos GM, Thauvin C, Gerson B, Moellering RC (1985) In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopepide antibiotic. Antimicrob Agents Chem-other 27:357–362

    Google Scholar 

  16. Fischer W (1977) The polar lipids of group B streptococci. II. Composition and positional distribution of fatty acids. Biochim Biophys Acta 487:89–104

    Google Scholar 

  17. Fischer W (1988) Physiology of lipoteichoic acids in bacteria. Adv Microb Physiol 29:233–302

    Google Scholar 

  18. Fischer W (1990) Bacterial phosphoglycolipids and lipoteichoic acids. In: Hanahan DJ (ed) Handbook of lipid research, Kates M (ed) vol 6. Plenum Press, New York, pp 123–234

    Google Scholar 

  19. Fischer W (1993) Molecular analysis of lipid macroamphiphiles by hydrophobic interaction chromatography, exemplified with lipoteichoic acids. Anal Biochem 208:49–56

    Google Scholar 

  20. Fischer W (1994) Lipoteichoic acids and lipoglycans. In: Ghuysen JM, Hakenbeck R (eds) New comprehensive biochemistry, vol 27. Elsevier, Amsterdam, pp 199–215

    Google Scholar 

  21. Fischer W (1994) Biological activities of lipoteichoic acids in the mammalian host. In: Faist E (ed) Proceedings of the 3rd International Congress on the immune consequences of trauma, shock and sepsis (Munich, March 1994). Springer, Berlin Heidelberg New York (in press)

    Google Scholar 

  22. Fischer W, Rösel P (1980) The alanine ester substitution of lipoteichoic acid (LTA) in Staphylococcus aureus. FEBS Lett 119:224–226

    Google Scholar 

  23. Fischer W, Koch HU, Rösel P, Fiedler F (1980) Alanine ester-containing native lipoteichoic acids do not act as lipoteichoic acid carrier. J Biol Chem 255:4557–4562

    Google Scholar 

  24. Fischer W, Rösel P, Koch HU (1981) Effect of alanine ester substitution and other structural features of lipoteichoic acids on their inhibitory activity against autolysins of Staphylococcus aureus. J Bacteriol 146:467–475

    Google Scholar 

  25. Fischer W, Mannsfeld T, Hagen G (1990) On the basic structure of poly (glycerophosphate) lipoteichoic acids. Biochem Cell Biol 68:33–43

    Google Scholar 

  26. Glaser L, Lindsay B (1974) The synthesis of lipoteichoic acid carrier. Biochem Biophys Res Commun 59:1131–1136

    Google Scholar 

  27. Glaser P, Kunst F, Arnaud M, Coudart M-P, Gonzales W, Hullo M-F, Ionescu M, Lubochinsky B, Marcelino M, Moszer I, Presecan E, Santana M, Schneider E, Schweizer J, Vertes A, Rapoport G, Danchin A (1993) Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325° to 333°. Mol Microbiol 10:371–384

    Google Scholar 

  28. Gutberlet T, Markwitz S, Labischinski H, Bradaczek H (1991) Monolayer investigations on the bacterial amphiphile lipoteichoic acid and on lipoteichoic acid/dipalmitoylphosphatidyl glycerol mixtures. Makromol Chem Makromol Symp 46:283–287

    Google Scholar 

  29. Haas R, Koch HU, Fischer W (1984) Alanyl turnover from lipoteichoic acid to teichoic acid in Staphylococcus aureus. FEMS Microbiol Lett 21:27–31

    Google Scholar 

  30. Hancock IC, Baddiley J (1985) Biosynthesis of the bacterial envelope polymers teichoic acid and teichuronic acid. In: Martonosi AN (ed) The enzymes of biological membranes, vol 2. Plenum Press, New York, pp 279–307

    Google Scholar 

  31. Heaton MP, Neuhaus FC (1992) Biosynthesis of d-alanyl-lipoteichoic acid: cloning, nucleotide sequence, and expression of the Lactobacillus casei gene for the d-alanine-activating enzyme. J Bacteriol 174:4707–4717

    Google Scholar 

  32. Heaton MP, Neuhaus FC (1994) Role of the d-alanyl carrier protein in the biosynthesis of d-alanyl-lipoteichoic acid. J Bacteriol 176:681–690

    Google Scholar 

  33. Heptinstall S, Archibald AR, Baddiley J (1970) Teichoic acids and membrane functions in bacteria. Nature 225:519–521

    Google Scholar 

  34. Herbold DR, Glaser L (1975) Interaction of N-acetylmuramic acid l-alanine amidase with cell wall polymers. J Biol Chem 250:7231–7238

    Google Scholar 

  35. Horne D, Tomasz A (1979) Release of lipoteichoic acid from Streptococcus sanguis: stimulation of release during penicillin treatment. J Bacteriol 137:1180–1184

    Google Scholar 

  36. Hummell DS, Winkelstein JA (1986) Bacterial lipoteichoic acid sensitizes host cells for destruction by autologous complement. J Clin Invest 77:1533–1538

    Google Scholar 

  37. Hummell DS, Swift AJ, Tomasz A, Winkelstein JA (1985) Activation of the alternative complement pathway by pneumococcal lipoteichoic acid. Infect Immun 47:384–387

    Google Scholar 

  38. Ishimoto N, Strominger JL (1966) Polyribitolphosphatesynthetase of Staphylococcus aureus strain Copenhagen. J Biol Chem 241:639–650

    Google Scholar 

  39. Keller R, Fischer W, Keist R, Bassetti S (1992) Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids. Infect Immun 60:3664–3672

    Google Scholar 

  40. Koch HU, Fischer W, Fiedler F (1982) Influence of alanine ester and glycosyl substitution on the lipoteichoic acid carrier activity of lipoteichoic acids. J Biol Chem 257:9473–9479

    Google Scholar 

  41. Koch HU, Haas R, Fischer W (1984) The role of lipoteichoic acid biosynthesis in membrane lipid metabolism of growing Staphylococcus aureus. Eur J Biochem 138:357–363

    Google Scholar 

  42. Koch HU, Döker R, Fischer W (1985) Maintenance of d-alanine ester substitution of lipoteichoic acid by re-esterification in Staphylococcus aureus. J Bacteriol 164:1211–1217

    Google Scholar 

  43. Kojima N, Araki Y, Ito E (1983) Structure of linkage region between ribitol teichoic acid and peptidoglycan in cell walls of Staphylococcus aureus H. J Biol Chem 258:9043–9045

    Google Scholar 

  44. Labischinski H, Naumann D, Fischer W (1991) Small and medium angle X-ray analysis of bacterial lipoteichoic acid phase structure. Eur J Biochem 202:1269–1274

    Google Scholar 

  45. Lambert PA, Hancock IC, Baddiley J (1975) Influence of alanyl ester residues on the binding of magnesium ions to teichoic acids. Biochem J 51:671–676

    Google Scholar 

  46. Lambert PA, Hancock IC, Baddiley J (1977) Occurrence and function of membrane teichoic acids. Biochim Biophys Acta 472:1–12

    Google Scholar 

  47. Loos M, Clas F, Fischer W (1986) Interaction of purified lipoteichoic acid with the classical complement pathway. Infect Immun 53:595–599

    Google Scholar 

  48. Mancuso DJ, Junker DD, Hsu SC, Chiu T-H (1979) Biosynthesis of glycosylated glycerolphosphate polymers in Streptococcus sanguis. J Bacteriol 140:547–554

    Google Scholar 

  49. Markham JL, Knox KW, Wicken AJ, Hewett MJ (1975) Formation of extracellular lipoteichoic acid by oral streptococci and lactobacilli. Infect Immun 12:378–386

    Google Scholar 

  50. Mauël C, Young M, Margot P, Karamata D (1989) The essential nature of teichoic acids in Bacillus subtilis as revealed by insertional mutagenesis. Mol Gen Genet 215:388–394

    Google Scholar 

  51. Ntamere AS, Taron JD, Neuhaus FC (1987) Assembly of d-alanyl lipoteichoic acid in Lactobacillus casei: mutants deficient in d-alanyl ester content of this amphiphile. J Bacteriol 169:1702–1711

    Google Scholar 

  52. Ou L-T, Marquis RE (1970) Electromechanical interactions in cell walls of gram-positive cocci. J Bacteriol 101:92–101

    Google Scholar 

  53. Pollack JH, Ntamere AS, Neuhaus FC (1992) d-Alanyl-lipoteichoic acid in Lactobacillus casei: secretion of vesicles in response to benzylpenicillin. J Gen Microbiol 138:849–859

    Google Scholar 

  54. Schleifer KH, Kroppenstedt RM (1990) Chemical and molecular classification of staphylococci. J Appl Bacteriol [Symp Suppl] 9S–24S

  55. Seydel U, Labischinski H, Kastowsky M, Brandenburg K (1993) Phase behavior, supramolecular structure, and molecular conformation of lipopolysaccharide. Immunobiology 187:191–211

    Google Scholar 

  56. Smith R, Tanford C (1972) The critical micelle concentration of l-α-dipalmitoylphosphatidylcholine in water and water/methanol solutions. J Mol Biol 67:75–83

    Google Scholar 

  57. Sugai M, Koike H, Hong Y-M, Miyake Y, Nogami R, Suginaka H (1989) Purification of a 51 kDa endo-β-N-acetylglucosaminidase from Staphylococcus aureus. FEMS Microbiol Lett 61:267–272

    Google Scholar 

  58. Taron DJ, Childs WC III, Neuhaus FC (1983) Biosynthesis of d-alanyl-lipoteichoic acid: role of diglyceride kinase in the synthesis of phosphatidylglycerol for chain elongation. J Bacteriol 154:1110–1116

    Google Scholar 

  59. Wadström T (1970) Bacteriolytic enzymes from Staphylococcus aureus. Properties of endo-β-N-acetyl-glucosaminidase. Biochem J 120:745–752

    Google Scholar 

  60. Ward JB (1981) Teichoic and teichuronic acids: biosynthesis, assembly and location. Microbiol Rev 45:211–243

    Google Scholar 

  61. Wicken AJ, Knox KW (1977) Immunological properties of lipoteichoic acids. Prog Immunol 3:135–143

    Google Scholar 

  62. Wicken AJ, Evans JD, Knox KW (1986) Critical micelle concentrations of lipoteichoic acids. J Bacteriol 166:72–77

    Google Scholar 

  63. Yokoyama K, Miyashita T, Araki Y, Ito E (1986) Structure and functions of linkage unit intermediates in the biosynthesis of ribitol teichoic acids in Staphylococcus aureus H and Bacillus subtilis W23. Eur J Biochem 161:479–489

    Google Scholar 

  64. Yokoyama K, Araki Y, Ito E (1988) The function of galactosylphosphorylpolyprenol in biosynthesis of lipoteichoic acid in Bacillus coagulans. Eur J Biochem 173:453–458

    Google Scholar 

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  1. Institut für Biochemie der Medizinischen Fakultät der Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054, Erlangen, Germany

    Werner Fischer

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This brief review is based on a presentation at the Gordon Conference on Staphylococcal Diseases, Andover, New Hampshire, USA, August 9–13, 1993

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Fischer, W. Lipoteichoic acid and lipids in the membrane of Staphylococcus aureus . Med Microbiol Immunol 183, 61–76 (1994). https://doi.org/10.1007/BF00277157

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