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Analysis of meiotic segregation in a man heterozygous for a 13;15 Robertsonian translocation and a review of the literature

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Summary

Meiotic segregation was studied in a male heterozygous for a 13;15 Robertsonian translocation using in vitro sperm penetration of hamster eggs. Sixty-seven sperm chromosome complements were obtained and R-banded. Alternate segregation produced equal numbers of normal (31) and balanced (29) gametes, as was theoretically expected. Incidence of unbalanced complements was 10.4%, and the frequency of abnormalities unrelated to the translocation was 7.4%. This study confirms the predominance of alternate meiotic segregation in Robertsonian translocation carriers. Four sperm studies of Robertsonian translocation have been previously reported. A review of the combined results points out the low incidence of imbalance in the sperm of Robertsonian translocation carrier and the lack of evidence for an interchromosomal effect.

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  1. Franck Pellestor

    Present address: Medical Genetics Clinic, Alberta Children's Hospital, 1820 Richmond Road S.W., T2T5C7, Calgary, Alberta, Canada

Authors and Affiliations

  1. Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, F-38700, La Tronche, France

    Franck Pellestor

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  1. Franck Pellestor
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Pellestor, F. Analysis of meiotic segregation in a man heterozygous for a 13;15 Robertsonian translocation and a review of the literature. Hum Genet 85, 49–54 (1990). https://doi.org/10.1007/BF00276325

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  • DOI: https://doi.org/10.1007/BF00276325

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