Summary
The relationship between arterial blood pressure and diabetic nephropathy was examined in 61 Type 1 (insulin-dependent) diabetic patients (22 females and 39 males). All patients fulfilled the following criteria: persistent proteinuria (>0.5g/day), onset of diabetes before 31 years of age, age <42 years, serum creatinine <130 μmol/l, and no antihypertensive treatment. Thirty Type 1 diabetic patients without persistent proteinuria but matched for sex, age, ideal body weight and duration of diabetes, and 30 healthy subjects matched for sex, age and ideal body weight were also studied as controls. The diabetic patients with persistent proteinuria had elevated blood pressures (146/96±17/10 mmHg, mean±SD) compared with 123/75±11/8 mmHg in diabetic patients without persistent proteinuria, and normal subjects (120/77±6/6 mmHg; p<0.001 for each). Diastolic blood pressure ⩾95 mmHg was found in 51% of the group with persistent proteinuria. Elevated arterial blood pressure is frequently present in young Type 1 diabetic patients with diabetic nephropathy and normal serum creatinine.
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References
Honey GE, Pryse-Davies J, Roberts DM (1962) A survey of nephropathy in young diabetics. Q J Med 31: 473–483
Thomsen AC (1965) The kidney in diabetes mellitus. Munksgaard, Copenhagen
Knowles HC (1974) Magnitude of the renal failure problem in diabetes. Kidney Int (Suppl) 6: 2–7
Ireland JT, Viberti GC, Watkins PJ (1982) The kidney and renal tract. In: Keen H, Jarrett J (eds) Complications of diabetes, 2nd eds. Edward Arnold, London, pp 166–172
Deckert T, Poulsen JE, Larsen M (1978) Prognosis of diabetics with diabetes onset before the age of thirty-one. Diabetologia 14: 363–370
Watkins PJ, Blainey JD, Brewer DB, Fitzgerald MG, Malins JM, O'Sullivan DJ, Pinto JA (1972) The natural history of diabetic renal disease. Q J Med 41: 437–456
Leading article (1978) Diabetes and hypertension. Lancet 2: 138–139
Parving H-H, Smidt UM, Friisberg B, Bonnevie-Nielsen V, Andersen AR (1981) A prospective study of glomerular filtration rate and arterial blood pressure in insulin-dependent diabetics with diabetic nephropathy. Diabetologia 20: 457–461
Larsen K (1972) Creatinine assay by a reaction-kinetic principle. Clin Chim Acta 41: 209–217
Laipply TC, Eitzen O, Dutra FR (1944) Intercapillary glomerulosclerosis. Arch Int Med 74: 354–364
Henderson LL, Spraue RG, Wagener HP (1947) Intercapillary glomerulosclerosis. Am J Med 3:131–144
Mendelow H, Britt G (1956) Intercapillary glomerulosclerosis. Aclinico-pathologic study. J Mt Sinai Hosp 23: 663–670
Bjerkelund CJ (1951) Diabetic renal disease. Acta Med Scand 139: 133–145
Malins J (1968) Clinical diabetes mellitus. Eyre and Spottiswoode, London, pp 152–185
Hatch FE, Watt MF, Kramer NC, Parrish AE, Howe JS (1961) Diabetic glomerulosclerosis. Am J Med 31: 216–230
Freedman P, Moulton R, Spencer AG (1958) Hypertension and diabetes mellitus. Q J Med 27: 293–305
Keen H, Track NS, Clive Sowry GS (1975) Arterial pressure in clinically apparent diabetics. Diabet Metabol (Paris) 1: 159–178
Deckert T, Poulsen JE (1981) Diabetic nephropathy: Fault or destiny? Diabetologia 21: 178–183
Christlieb AR (1973) Diabetes and hypertensive vascular disease. Am J Cardiol 32: 592–606
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Parving, H.H., Andersen, A.R., Smidt, U.M. et al. Diabetic nephropathy and arterial hypertension. Diabetologia 24, 10–12 (1983). https://doi.org/10.1007/BF00275939
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DOI: https://doi.org/10.1007/BF00275939