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A mathematical model of heterogeneous behavior of single muscle fibres

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Abstract

A mathematical model of contracting muscle fibre is studied. The model is composed of an array of segments placed in series; any segment has an elastic element (PE i ) and a contractile element (CE i ) that describes the cross bridge kinetics.

The corresponding system of nonlinear partial differential equations of the model is analyzed. Existence, uniqueness and continuous dependence of the solution are proven.

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References

  1. Browder F.: Problèmes non linéaires. Lecture Notes, University of Montréal 1966

  2. Capelo A., Comincioli V., Minelli R., Poggesi C., Reggiani C., Ricciardi L.: Study and parameters identification of a rheological model for excised quiescent cardiac muscle. J. Biomechanics 14, 1–11 (1981)

    Google Scholar 

  3. Comincioli V., Torelli A.: Mathematical aspects of the cross-bridge mechanism in muscle contraction. Nonlinear analysis, theory, methods and applications 7, 661–683 (1983)

    Google Scholar 

  4. Comincioli V., Torelli A., Poggesi C., Reggiani C.: A four-state cross bridge model for muscle contraction. Mathematical study and validation. J. Math. Biol. 20, 277–304 (1984)

    Google Scholar 

  5. Comincioli V., Torelli A., Poggesi C., Reggiani C.: Mathematical models for contracting muscle. France-Italy-URSS 6th joint symposium 1983, I.N.R.I.A. 52–65 (1984)

  6. Douglas J., Milner F. A.: Numerical methods for a model of cardiac muscle contraction. Calcolo XX, 123–141 (1983)

    Google Scholar 

  7. Eisemberg E., Hill T. L.: A cross-bridge model of muscle contraction. Prog. Biophys. Mol. Biol. 33, 55–82 (1978)

    Google Scholar 

  8. Edman K. A. P., Reggiani C.: Redistribution of sarcomere length during isometric contraction of frog muscle fibres and its relation to tension creep. J. Physiol. 351, 169–198 (1984)

    Google Scholar 

  9. Edman K. A. P., Reggiani C.: Absence of plateau of the sarcomere length-tension relation in frog muscle fibres. Acta Physiol. Scand. 122, 213–216 (1984)

    Google Scholar 

  10. Gastaldi L., Tomarelli F.: A nonlinear hyperbolic Cauchy problem arising in the dynamic of cardiac muscle. Pubbl. I.A.N. del C.N.R., Pavia no. 340 (1983)

  11. Gastaldi L., Tomarelli F.: A uniqueness result for a nonlinear hyperbolic equation. Ann. Mat. Pura Appl. (4), 137, 175–205 (1984)

    Google Scholar 

  12. Hill T. L.: Theoretical formalism for the sliding filament model of contraction of striated muscle, Part I. Prog. Biophys. Mol. Biol. 28, 267–340 (1974)

    Google Scholar 

  13. Hill T. L.: Theoretical formalism for the sliding filament model of contraction of striated muscle, Part II. Prog. Biophys. Mol. Biol. 29, 105–159 (1975)

    Google Scholar 

  14. Huxley A. F.: Muscle structure and theories of contraction. Prog. Biophys. Biophys. Chem. 7, 255–318 (1957)

    Google Scholar 

  15. Minelli R., Comincioli V., Poggesi C., Reggiani C., Ricciardi L.: Mathematical models for isolated resting and active cardiac muscle. Progetto HUSPI 6, 105–130 (1981)

    Google Scholar 

  16. Poggesi C., Comincioli V., Reggiani C., Ricciardi L., Minelli R.: A model of contracting cardiac muscle. Proc. Third Meeting of the European Society of Biomechanics. Nijmegen 1982

  17. Potter A. J. B.: An elementary version of the Leray-Schauder Theorem. J. London Math. Soc. 5, 414–416 (1972)

    Google Scholar 

  18. Reggiani C., Edman K. A. P., Comincioli V., Poggesi C., Ricciardi L., Bottinelli R., Hoglund O.: Model simulation of non-uniform behaviour of single muscle fibres. Progetto HUSPI 8, 191–198 (1984)

    Google Scholar 

  19. Torelli A.: A non linear hyperbolic equation related to the dynamics of cardiac muscle. Portugaliae Mathematica, 41, 171–188 (1982)

    Google Scholar 

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This work has been supported by Ministero Pubblica Istruzione (fondi per la ricerca scientifica) and by Istituto di Analisi Numerica del C.N.R., Pavia

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Colli, P. A mathematical model of heterogeneous behavior of single muscle fibres. J. Math. Biology 24, 103–118 (1986). https://doi.org/10.1007/BF00275723

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  • DOI: https://doi.org/10.1007/BF00275723

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