Summary
Sperm chromosomes from two human males, each heterozygous for a different reciprocal translocation, were examined. Chromosomally normal sperm were found in equal numbers to those carrying the translocation in the balanced form, in both males. Alternate segregation was more common than adjacent segregation in both translocations. Male W.G. had a greater proportion of sperm containing chromosome abnormalities unrelated to the translocation than did J.S., the second made studied. J.S. however, had a greater frequency of chromosomally unbalanced sperm. The great majority of unbalanced sperm in both males was due to adjacent I segregation.
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References
Akesson A, Henricson B (1972) Embryonic death in pigs caused by unbalanced karyotype. Acta Vet Scand 13:151–160
European Collaborative Study of Chromosome Abnormalities During Prenatal Diagnosis (1981) Proceedings of the Sixth International Congress of Human Genetics. Alan R. Liss, Jerusalem
Ford CE (1969) Meiosis in mammals. In: Benirschke K (ed) Comparative mammalian cytogenetics. Springer Verlag, New York, pp 91–106
Grell RF (1967) Pairing at the chromosome level. J Cell Physiol 70:119–146
Ljeune J, Dutrillaux B, de Grouchy J (1970) Reciprocal translocations in human populations: A preliminary analysis. In: Jacobs PA, Price WH, Law P (eds) Human population cytogenetics. Edinburgh University Press, Edinburgh, pp 81–87
Lindenbaum RH, Bobrow M (1975) Reciprocal translocation in man. 3:1 meiotic disjunction resulting in 47- or 45- chromosome off-spring. J Med Genet 12:29–43
Martin RH, Lin CC, Balkan W, Burns K (1982) Direct chromosomal analysis of human spermatozoa: Preliminary results from 18 normal men. Am J Hum Genet 34:459–468
Martin RH, Balkan W, Burns K, Rademaker AW, Lin CC, Rudd NL (1983) The chromosome constitution of 1000 human spermatozoa. Hum Genet
McClintock B (1945) Neurospora: I. Preliminary observations on the chromosomes of Neurospora crassa. Am J Bot 32:671–678
Mikamo K (1970) Anatomic and chromosomal anomalies in spontaneous abortion: Possible correlation with over-ripeness of oocytes. Am J Obstet Gynecol 106:243–254
Oshimura M, Takagi N (1975) Meiotic disjunction in T(14;15)6Ca heterozygotes and fate of chromosomally unbalanced gametes in embryonic development. Cytogenet Cell Genet 15:1–16
Rudak E, Jacobs PA, Yanagimachi R (1978) Direct analysis of the chromosome constitution of human spermatozoa. Nature 274:911–913
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Balkan, W., Martin, R.H. Chromosome segregation into the spermatozoa of two men heterozygous for different reciprocal translocations. Hum Genet 63, 345–348 (1983). https://doi.org/10.1007/BF00274760
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DOI: https://doi.org/10.1007/BF00274760