Summary
Serum samples from 79 healthy subjects and 31 patients with type I amyloid neuropathy were typed for nine Gm markers. No significant associations were found between any of the Gm phenotypes and the disease. The frequencies of the various phenotypes showed satisfactory agreement with the Hardy-Weinberg distribution. One individual had an unusual Gm phenotype.
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References
Andrade C, Canijo M, Klein D, Kaelin A (1969) The genetic aspect of the familial amyloidotic polyneuropathy. Humangenetik 7:163–175
Da Silva BM, Santarem MM, Arala-Chaves MP (1980) Evidence for high incidence of HLA-A2 and HLA-A9 in patients afflicted with type I (Andrade) amyloid neuropathy—preliminary studies. In: Glenner GG, e Costa PP, deFreitas AF (eds) Amyloid and amyloidosis. Excerpta Medica, Amsterdam, pp 125–130
Fraser GR, Volkers WS, Bernini LF, van Loghem E, Khan PM, Nihenhuis LE (1974) Gene frequencies in a Dutch population. Hum Hered 24:435–448
Grubb R (1970) The genetic markers of human immunoglobulins. Springer, Berlin Heidelberg New York
Kurczynski TW, Steinberg AG (1967) A general program for maximum likelihood estimation of gene frequencies. Am J Hum Genet 19: 178–179
Pandey JP, Fudenberg HH, Amos DB (1978) A Caucasian pedigree demonstrating the transmission of a Gm1,2,17,5,13,14 haplotype. J Immunogenet 5:1–4
Pereira TM, Manso C (1975) Immunoglobulin allotypes in Portugal. Humangenetik 27:137–140
Steinberg AG, Cook CE (1981) The distribution of the human immunoglobulin allotypes. Oxford University Press, New York
Whittingham S, Mathews JD, Schanfield MS, Tait BD, Mackay IR (1981) Interaction of HLA and Gm in autoimmune chronic active hepatitis. Clin Exp Immunol 43:80–86
Vyas GN, Fudenberg HH, Pretty HM, Gold ER (1968) A new rapid method for genetic typing of human immunoglobulins. J Immunol 100:274–279
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Publication no. 526 from the Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina. Research supported in part by USPHS Grants CA-25746 and AI-07063, and by South Carolina State Appropriations for Research
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Pandey, J.P., Shannon, B.T., Arala-Chaves, M.P. et al. Gm and Km frequencies in a Portugese population. Hum Genet 61, 154–156 (1982). https://doi.org/10.1007/BF00274207
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DOI: https://doi.org/10.1007/BF00274207