Summary
Correlated responses to selection for increased 3–6 week postweaning gain in male mice were estimated for seven internal organs (testes, spleen, liver, kidneys, heart, small intestine (S intest) and stomach) weighed at specific degrees of maturity in body weight (37.5, 50.0, 62.5, 75.0, 87.5 and 100%). Correlated responses in organ weights were generally large, but the magnitude and direction of response depended upon whether 1) comparisons were made at the same age, degree of maturity or body weight and 2) absolute or proportional organ weights were used. The selected line (M16) weighed more and had larger organ weights than controls (ICR) when compared at either the same degree of maturity or the same age, indicating positive genetic correlations between body weight and the respective organ weights. Positive correlated responses were found in spleen weight/body weight at all degrees of maturity and in liver and S intest weights as a proportion of body weight at some degrees of maturity. Testes, kidneys, heart and stomach weights as a proportion of body weight had negative correlated responses, though this was consistent only for kidneys across all degrees of maturity. Correlated responses in organ weights adjusted for body weight by covariance analysis were positive for spleen, S intest and stomach and negative for testes and kidneys. Based on the constrained quadratic model, degree of maturity in organ weight relative to degree of maturity in body weight responded positively for testes, kidneys and S intest and negatively for spleen and liver. Selection for increased growth caused negative correlated responses in allometric growth of testes, kidneys, S intest and stomach.
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References
Allen P, McCarthy JC (1980) The effects of selection for high and low body weight on the proportion and distribution of fat in mice. Anim Prod 31:1–11
Atchley WR (1984) The effect of selection on brain and body size association in rats. Genet Res 43:289–298
Baldwin RL, Smith NE, Taylor J, Sharp M (1980) Manipulating metabolic parameters to improve growth rate and milk secretion. J Anim Sci 51:1416–1428
Brown V, Davies RG (1972) Allometric growth in two species of Ectobius (Dictyoptera: Blattidae). J Zool 166:97–132
Bünger L, Remus N, Roschlau D (1985) Selection for different growth parameters in laboratory mice and its correlated effects on body composition and organ weights. Die Nahrung 29:549–560
Butterfield RM, Griffiths DA, Thompson JM, Zamora J, James AM (1983a) Changes in body composition relative to weight and maturity in large and small strains of Australian Merino rams. 1. Muscle, bone and fat. Anim Prod 36:29–37
Butterfield RM, Zamora J, James AM, Thompson JM, Reddacliff KJ (1983b) Changes in body composition relative to weight and maturity in large and small strains of Australian Merino rams. 3. Body organs. Anim Prod 36:461–470
Byrne I, Hooper JC, McCarthy JC (1973) Effects of selection for body size on the weight and cellular structure of seven mouse muscles. Anim Prod 17:187–196
Cochard LR (1985) Ontogenetic allometry of the skull and dentition of the rhesus monkey (Macaca mulatta). In: Jungers WL (ed) Size and scaling in primate biology. Plenum Press, New York, pp 231–255
Davies RG, Brown V (1972) A multivariate analysis of post-embryonic growth in two species of Ectobius (Dictyoptera: Blattidae). J Zool 168:51–79
Doornenbal H, Tong AKW (1981) Growth, development and chemical composition of the pig. 4. Relative growth of visceral organs. Growth 45:270–285
Eisen EJ (1975) Population size and selection intensity effects on long-term selection response in mice. Genetics 79:305–323
Eisen EJ (1987) Effects of selection for rapid postweaning gain on maturing patterns of fat depots in mice. J Anim Sci (in press)
Eisen EJ, Johnson BH (1981) Correlated responses in male reproductive traits in mice selected for litter size and body weight. Genetics 99:513–524
Eisen EJ, Leatherwood JM (1978) Adipose cellularity and body composition in polygenic obese mice as influenced by preweaning nutrition. J Nutr 108:1652–1662
Eisen EJ, Hayes JF, Allen CE, Bakker H, Nagai J (1978) Cellular characteristics of gonadal fat pads, livers and kidneys in two strains of mice selected for rapid growth. Growth 42:7–25
Falconer DS, Gauld IK, Roberts RC (1978) Cell numbers and cell sizes in organs of mice selected for large and small body size. Genet Res 31:287–301
Garlick PJ, Burk GL, Swick RW (1976) Protein synthesis and RNA in tissues of the pig. Am J Physiol 230:1108–1112
Gould SJ (1966) Allometry and size in ontogeny and phylogeny. Biol Rev 41:587–640
Harvey WR (1979) Least-squares analysis of data with unequal subclass numbers. USDA ARS H-4, Beltsville
Hooper ACB (1977) Effects of divergent selection for body weight on bone length and diameter in mice. Anim Prod 24:77–82
Huxley JS (1932) Problems of relative growth. Methuen, London
Jolicoeur P (1963 a) The multivariate generalization of the allometry equation. Biometrics 19:497–499
Jolicoeur P (1963 b) The degree of generality of robustness in Martes americana. Growth 27:1–27
Larson SG (1985) Organ weight scaling in primates. In: Jungers WL (ed) Size and scaling in primate biology. Plenum Press, New York, pp 91–113
Morrison DF (1976) Multivariate statistical methods. McGraw-Hill, New York
Nash DJ, Logsdon DF Jr (1978) Morphological and physiological changes in mice (Mus musculus) selected for large size. Comp Biochem Physiol A 61:283–285
Parks JR (1983) A note on the theoretical relation between the fractions of maturity of organs and of the whole animal. Anim Prod 37:145–148
Robinson DW, Bradford GE (1969) Cellular response to selection for rapid growth in mice. Growth 33:221–279
Shea BT (1985) Bivariate and multivariate growth allometry: statistical and biological considerations. J Zool 206:367–390
Shibata K (1965) Genetical and biometrical studies on the body weight of mice. 6. Genetic and phenotypic correlations between adult body weight and viscus weight, and among viscera weights in F1 hybrids of highly inbred albino strains. J Agr Sci, Tokyo Nogyo Daigaku 11:57–61
Taylor St CS (1980 a) Genetic size-scaling rules in animal growth. Anim Prod 30:161–165
Taylor St CS (1980 b) Genetically standardized growth equations. Anim Prod 30:167–175
Taylor St CS (1985) Use of genetic size-scaling in evaluation of animal growth. In: Current concepts of animal growth, vol 1. J Anim Sci 61 (Suppl 2):118–143
Tess MW, Dickerson GE, Nienaber JA, Ferrell CL (1984) The effects of body composition on fasting heat production in pigs. J Anim Sci 58:99–110
Tess MW, Dickerson GE, Nienaber JA, Ferrell CL (1986) Growth development and body composition in three genetic stocks of swine. J Anim Sci 62:968–979
Trieb G, Pappritz G, Lutzen L (1976) Allometric analysis of organ weights. 1. Rats. Toxicol Appl Pharmacol 35:531–542
Webster SH, Liljegren EJ (1955) Organ: body-weight ratios for certain organs of laboratory animals. 3. White Swiss mouse. Am J Anat 85:199–230
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Communicated by H. F. Linskens
Paper No. 10,545 of the Journal Series of the North Carolina Agricultural Research Service, Raleigh, 27695-7601. The use of trade names in this publication does not imply endorsement by the North Carolina Agricultural Research Service of the products named, nor criticism of similar ones not mentioned
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Eisen, E.J. Maturing patterns of organ weights in mice selected for rapid postweaning gain. Theoret. Appl. Genetics 73, 148–157 (1986). https://doi.org/10.1007/BF00273732
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DOI: https://doi.org/10.1007/BF00273732