Summary
Linkage has been described between the loci for apolipoprotein E (apoE) and the complement C3 (C3) on chromosome 19. C3 is known to belong to a linkage group with gene order C3-Se-Lu. The present study revealed linkage between Se and apoE with peak lod score +3.3 at recombination fraction 0.08 in males and +1.36 at 0.22 in females, and linkage between apoE and Lu with lod score +4.52 at zero recombination in sexes combined. The C3-apoE linkage gives lod score +4.00 at \(\hat \Theta\)= 0.18 in males, but +0.04 at \(\hat \Theta\)=0.45 in females. Triple heterozygote families confirm that apoE is on the Se side and on the Lu side of C3. Allelic association between apoE and Lu has not been ruled out. Combining our data with published data on C3-Se and Se-Lu, this segment of chromosome 19 has an average sex ratio of female/male recombination of 2.3.
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Ball S, Buckton KE, Corney G, Fey G, Monteiro M, Noades JE, Pym B, Robson EB, Tippett P (1984) Mapping studies with peptidase D (PEPD). Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:411
Berg K, Børresen A-L, Heiberg A, Maartmann-Moe K (1984a) Study of the linkage relationship between apoE and familial hypercholesterolemia with xanthomatosis. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:418
Berg K, Heiberg A (1976) Linkage studies on familial hyperlipoproteinemia with xanthomatosis: normal lipoprotein markers and the C3 polymorphism. Human Gene Mapping 3, Baltimore Conference 1975. Cytogenet Cell Genet 16:266–270
Berg K, Julsrud JO, Børresen A-L, Fey G, Humphries SE (1984b) Study of the ApoE-C3 linkage relationship using a polymorphic DNA marker for C3. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:417
Cook PJL (1965) The Lutheran-secretor recombination fraction in man: a possible sex difference. Ann Hum Genet 28:393–401
Cumming AM, Robertson FW, Tippett P, Noades JE, Ball S (1984) Linkage data on apoprotein-E (APO-E) with respect to chromosome 19 markers. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:445
Donald JA, Humphries SE, Tippett P, Noades JE, Ball S (1984) Linkage relationships of familial hypercholesterolemia and chromosome 19 markers. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:452
Eiberg H, Mohr J, Nielsen LS, Simonsen N (1982) Linkage relations between the locus for C3 and 50 polymorphic systems: Assignment of C3 to the DM-Se-Lu linkage group: Confirmation of C3-LES linkage; support of LES-DM synteny. Proc VI Int Cong Hum Genet, Jerusalem 1981
Eiberg H, Mohr J, Staub Nielsen L (1983) Indication of linkage between the PEPD locus and the C3-DM-Le-Lu linkage group and support for assignment of this linkage group to chromosome no. 19. Clin Genet 23:228
Elston RC, Namboodiri KK, Go RCP, Siervogel RM, Glueck CJ (1976) Probable linkage between essential familial hypercholesterolemia and third complement component (C3). Human Gene Mapping 3, Baltimore Conference 1975. Cytogenet Cell Genet 16:294–297
Falk C, Walker ME, Martin MD, Allen FH (1975) Autosomal linkage in humans. Methodology and results of computer analysis. Ser Haematol 8:153–237
Gedde-Dahl T Jr, Teisberg P, Thorsby E (1974) C3 polymorphism: Genetic linkage relations. Clin Genet 6:66–72
Grubb R (1953) Zur Genetik des Lewis-Systems. Naturwissenschaften 21:560–561
Keats BJB (1981) Linkage and chromosome mapping in man. The University Press of Hawaii, Honolulu
Keats BJB, Morton NE, Rao DC, Williams WR (1979) A source book for linkage in man. Johns Hopkins University Press, Baltimore London
McAlpine PJ, Mohandas T, Ray M, Wang H, Hamerton JL (1976) Assignment of the peptidase D gene locus (PEPD) to chromosome 19 in man. Human Gene Mapping 3, Baltimore Conference 1975. Cytogenet Cell Genet 16:204–205
Mohr J (1951) Estimation of linkage between the Lutheran and the Lewis blood groups. Acta Path Microbiol Scand 29:339–344
Mohr J (1954) A study of linkage in man. Munksgaard, Copenhagen
Mohr J, Eiberg H (1979) Linkage relations of the ABH-secretor system with 33 other marker were considered in our family material No. 604-1505. Human Gene Mapping 5, Edinburgh Conference 1979. Cytogenet Cell Genet 25:188
Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277–318
O'Brien T, Ball S, Sarfarazi M, Harper PS, Robson EB (1983) Genetic linkage between the loci for myotonic dystrophy and peptidase D. Ann Hum Genet 47:117–121
Olaisen B, Teisberg P, Gedde-Dahl T Jr (1982) The locus for apolipoprotein (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man. Hum Genet 62:233–236
Olaisen B, Teisberg P, Gedde-Dahl T Jr, Constant Wilhelmy M, Mevåg B, Helland R (1984) The apolipoprotein E (apoE) locus on human chromosome 19. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:559
Oriol R, Le Pendu J, Bernez L, Lambert F, Dalix AM, Hawkins BR (1984) International cooperative study confirming close linkage between H and Se. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:564
Renwick JH (1968) Ratios of female to male recombination fractions in man. Bull Eur Soc Hum Genet 2:7–14
Renwick JH, Bolling DR (1971) An analysis procedure illustrated on triple linkage of use for prenatal diagnosis of myotonic dystrophy. J Med Genet 8:399–406
Simola K, de la Chapelle A, Pirkola A, Karli P, Cook PJL, Tippett PA (1982). Data on DM-Le linkage. Human Gene Mapping 6, Oslo Conference 1981. Cytogenet Cell Genet 32:317
Weitkamp LT, Johnston E, Guttormsen SA (1974) Probable genetic linkage between the loci for the Lewis blood group and complement C3. Human Gene Mapping 1, New Haven Conference 1973. Cytogenet Cell Genet 13:183–184
Westerveld A, Naylor S (1984) Report of the committee on the genetic constitution of chromosomes 18, 19, 20, 21, and 22. Human Gene Mapping 7, Los Angeles Conference 1983. Cytogenet Cell Genet 37:155–175
Whitehead AS, Solomon E, Chambers SP, Povey S, Bodmer WF (1982) Assignment of the gene for the third component of human complement (C3) to chromosome 19 using human-mouse somatic cell hybrids. Human Gene Mapping 6, Oslo Conference 1981. Cytogenet Cell Genet 32:326–327
Wøien D (1970) Description of MOSM, program for genetic linkage analysis. Norwegian Computing Center
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Gedde-Dahl, T., Olaisen, B., Teisberg, P. et al. The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19. Hum Genet 67, 178–182 (1984). https://doi.org/10.1007/BF00272996
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DOI: https://doi.org/10.1007/BF00272996