Summary
The Robertsonian translocation 45,X,t(Y;15q) was detected in four generations of male progeny. The karyotypes were studied by G-, Q-, and C-banding techniques. The chromosome Y involved in this translocation was of a “short”, “nonfluorescent” variant. The normal male phenotypes in all three adult translocation carriers (the great grandfather, the grandfather, and the father) support the hypothesis that the locus for the male determining factor is on the short arm of the chromosome Y.
Zusammenfassung
Eine Robertsonsche Translokation 45,X,t(Y;15q) wurde in vier Generationen der männlichen Linie entdeckt. Die Karyotypen wurden mittels der G-, R- und C-Banding-Techniken untersucht. Das in diese Translokation verwickelte Y-Chromosom gehörte zu der “kurzen”, nichtfluorescierenden Variante. Alle Translokationsträger aus vier Generationen hatten einen normalen männlichen Phänotyp. Dadurch wird die Hypothese bestätigt, daß der Locus für den die Männlichkeit bestimmenden Faktor auf dem kurzen Arm des Y-Chromosoms gelegen ist.
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Šubrt, I., Blehová, B. Robertsonian translocation between the chromosome Y and 15. Hum Genet 23, 305–309 (1974). https://doi.org/10.1007/BF00272514
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DOI: https://doi.org/10.1007/BF00272514