Summary
It is shown that pyrimidine dimers formed by ultraviolet light in the DNA of haploid Saccharomyces cerevisae are removed under the influence of photoreactivating light and also in the dark under growth conditions. The integrity of the rad 1 locus is necessary for the dark-removal of dimers.
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Boyce, R. P., Howard-Flanders, P.: Release of ultraviolet and light-induced thymine dimers from DNA in E. coli K12. Proc. nat. Acad. Sci. (Wash.) 51, 293–300 (1964).
Game, J. C., Cox, B. S.: Allelism tests of mutants affecting sensitivity to radiation in yeast and a proposed nomenclature. Mutation Res. 12, 328–331 (1971).
Nakai, S., Matsumoto, S.: Two types of radiation-senstive mutant in yeast. Mutation Res. 4, 129–136 (1967).
Parry, J. M., Cox, B. S.: The effects of dark holding and photo-reactivation on ultraviolet light-induced mitotic recombination and survival in yeast. Genet. Res. 12, 187–198 (1968).
—, Parry, E. M.: The effects of UV-light post-treatments on the survival characteristics of 21 UV-sensitive mutants of Saccharomyces cerevisiae. Mutation Res. 8, 545–556 (1969).
Patrick, M. H., Haynes, R. H., Uretz, R. B.: Dark recovery phenomena in yeast. I. Comparative effects with various inactivating agents. Radiat. Res. 21, 144–163 (1964).
Setlow, R., Carrier, W. L.: The disappearance of thymine dimers from DNA: an error-correcting mechanism. Proc. nat., Acad. Sci. (Wash.) 51, 226–231 (1964).
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Communicated by Ch. Auerbach
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Unrau, P., Wheatcroft, R. & Cox, B.S. The excision of pyrimidine dimers from DNA of ultraviolet irradiated yeast. Molec. Gen. Genet. 113, 359–362 (1971). https://doi.org/10.1007/BF00272336
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DOI: https://doi.org/10.1007/BF00272336