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Exclusion of chromosomal mosaicism in prenatal diagnosis

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Summary

For use in prenatal diagnosis, tables were prepared giving the number of metaphases or clones, respectively, which must be analysed in order to detect fetal mosaicism of a given degree (=percentage of the aberrant cell population) or higher with at least 95% or 99% probability. Different tables are provided for the two techniques of chromosomal preparation: the colony method and the flask method.

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Author information

Authors and Affiliations

  1. Institute of Human Genetics and Anthropology, University of Düsseldorf, D-4000, Düsseldorf, FRG

    Uwe Claussen

  2. Institute for Medical Documentation, Statistics and Data Processing, University of Heidelberg, D-6900, Heidelberg, FRG

    Helmut Schäfer

  3. Institute of Medical Statistics and Biomathematics, University of Düsseldorf, D-4000, Düsseldorf, FRG

    Hans J. Trampisch

Authors
  1. Uwe Claussen
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  2. Helmut Schäfer
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  3. Hans J. Trampisch
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Claussen, U., Schäfer, H. & Trampisch, H.J. Exclusion of chromosomal mosaicism in prenatal diagnosis. Hum Genet 67, 23–28 (1984). https://doi.org/10.1007/BF00270553

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  • DOI: https://doi.org/10.1007/BF00270553

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