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Effect of gold salt treatment on the receptor binding activity of monocytes and macrophages isolated from rats with adjuvant arthritis

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Summary

We investigated the effect of chrysotherapy on the Fc and complement receptor binding activity of peripheral blood (PB) monocytes and peritoneal (PE) macrophages isolated from normal rats and rats with adjuvant induced arthritis. The adjuvant induced severe disease in Dark Agouti (DA) rats and less marked disease in J. C. Lewis (JC) rats. Gold treatment reduced the disease in DA rats but exacerbated the disease in JC rats. PB monocytes generally exhibited increased receptor activity after adjuvant injection. Gold treatment resulted in a simultaneous reduction of the PB monocyte receptor activity and increased the PE macrophage receptor activity. This was considered to be due to a direct effect of gold, since the Fc receptor activity of PE macrophages increased after in vitro gold treatment.

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References

  1. Lewis AJ, Walz DT (1982) Immunopharmacology of gold. In: Ellis GP, West GB (eds) Progress in medical chemistry. Elsevier, New York, pp 1–42

    Google Scholar 

  2. Liebfarth JH, Persellin RH (1981) Review: mechanism of action of gold. Agents Actions 11:458–472

    Google Scholar 

  3. Lipsky PE, Ziff M (1977) Inhibition of antigen and mitogen induced human lymphocyte proliferation by gold compounds. J Clin Invest 59:455–466

    Google Scholar 

  4. Persellin RH, Ziff M (1966) The effect of gold salts on lysosomal enzymes of the peritoneal macrophage. Arthritis Rheum 9:57–65

    Google Scholar 

  5. Vernon-Roberts B, Dore JL, Jessop JD, Henderson WJ (1976) Selective concentration and localization of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients. Ann Rheum Dis 35:477–486

    Google Scholar 

  6. Ghadially FN, Oryschak AF, Mitchell DM (1976) Ultrastructural changes in rheumatoid synovial membrane by chrysotherapy. Ann Rheum Dis 35:67–72

    Google Scholar 

  7. Norton WL, Lewis DC, Ziff M (1968) Electron-dense deposits following injection of gold sodium thiomalate and thiomalic acid. Arthritis Rheum 11:436–443

    Google Scholar 

  8. Nakamura H, Igarashi M (1977) Localization of gold in synovial membrane of rheumatoid arthritis treated with sodium aurothiomalate: studies by electron microscope and electron probe X-ray microanalysis. Ann Rheum Dis 36:209–215

    Google Scholar 

  9. Ugai K, Ziff M, Lipsky PE (1979) Gold induced changes in morphology and functional capabilities of human monocytes. Arthritis Rheum 22:1352–1360

    Google Scholar 

  10. Jessop JD, Vernon-Roberts B, Harris J (1973) Effects of gold salts and prednisolone on inflammatory cells. I. The phagocytic activity of macrophages and neutrophil polymorphs in inflammatory exudates studied by the “skinwindow” technique in rheumatoid and control subjects. Ann Rheum Dis 32:294–299

    Google Scholar 

  11. Vernon-Roberts B, Jessop JD, Dore J (1973) Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat. Ann Rheum Dis 32:301–306

    Google Scholar 

  12. Scheinborg MA, Santos LMB, Finkelstein AE (1982) The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes. J Rheumatol 9:3, 366–369

    Google Scholar 

  13. Ho PPK, Young AL, Southard GL (1978) Methyl ester of N-formylmethionyl-leucyl-phenylalanine: chemotactic responses of human blood monocytes and inhibition of gold compounds. Arthritis Rheum 21:133–136

    Google Scholar 

  14. Otha A, Louie JS, Uitto J (1986) Collagenase production by human mononuclear cells in culture: inhibition by gold containing compounds and other antirheumatic agents. Ann Rheum Dis 45:996–1003

    Google Scholar 

  15. Moroz LA (1979) Effects of gold sodium thiomalate on fibrinolysis. J Rheumatol 6 (suppl 5):149–153

    Google Scholar 

  16. Pruzanski W, Saito S, DeBoer G (1983) Modulation of phagocytosis and bactericidal activity of human polymorphonuclear and mononuclear phagocytes by antiarthritic agents. J Rheumatol 10:197–203

    Google Scholar 

  17. Sung CP, Mirabelli CK, Badger J (1984) Effect of gold compounds on phorbol myristic acetate (PMA) activated superoxide (O -2 ) production by mouse peritoneal macrophages. J Rheumatol 11:153–158

    Google Scholar 

  18. Hafstrom I, Seligman BE, Friedman MM, Gallin JI (1984) Auranofin affects early events in human polymorphonuclear neutrophil activation by receptor-mediated stimuli. J Immunol 132:2007–2014

    Google Scholar 

  19. Griswold DE, Lee JC, Poste G, Hanna N (1985) Modulation of macrophage lymphocyte interactions by the antiarthritic gold compound, auranofin. J Rheumatol 12:490–497

    Google Scholar 

  20. Petersen J, Bendtzen K (1982) Involvement of monokines in antigen-and lectin-induced human lymphokine production. Acta Pathol Microbiol Immunol Scand [C] 90:229

    Google Scholar 

  21. Blistein-Willinger E (1985) Normalization of defective interleukin 1 and interleukin 2 production in patients with pemphigus vulgaris following chrysotherapy. Clin Exp Immunol 62:705–714

    Google Scholar 

  22. Yam LT, Li CY, Crosby WH (1971) Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 55:283–290

    Google Scholar 

  23. Kaplow LS (1965) Simplified myeloperoxidase stain using benzidine dihydrochloride. Blood 26:215–218

    Google Scholar 

  24. Garrett IR, Whitehouse MW, Vernon-Roberts B, Brooks PM (1985) Ambivalent effects of gold drugs in adjuvant induced polyarthritis in rats. J Rheumatol 12:1079–1082

    Google Scholar 

  25. Katayma S, Chia D, Nasu H, Knutson DW (1981) Increased Fc receptor activity in monocytes from patients with rheumatoid arthritis: a study of monocyte binding and catabolism of soluble aggregates of IgG in vivo. J Immunol 127:643–647

    Google Scholar 

  26. Hoch S, Schur PH (1981) Monocyte receptor function in patients with rheumatoid arthritis. Arthritis Rheum 24:1268–1227

    Google Scholar 

  27. Carter SD, Bourne JT, Elson CJ, Hutton CW, Czudek R, Dieppe PA (1984) Mononuclear phagocytes in rheumatoid arthritis: Fc-receptor expression by peripheral blood monocytes. Ann Rheum Dis 43:424–429

    Google Scholar 

  28. Vernon-Roberts B, Liyanage SP, Currey HLF (1976) Adjuvant arthritis in the rat. Distribution of fluorescent material after footpad injection of rhodamine-labelled tubercle bacilli. Ann Rheum Dis 35:389–397

    Google Scholar 

  29. Lorber A, Cohn RL, Chang C, Anderson HE (1968) Gold determination in biologiocal fluids by atomic absorption spectrometry. Arthritis Rheum 11:170–177

    Google Scholar 

  30. Garrett IR (1986) Studies of the effects of metal containing drugs on acute and chronic inflammation. PhD thesis, University of Adelaide, Australia

    Google Scholar 

  31. McCormack PL, Myers DB, Palmer DG (1978) Increase in Fc receptor activity of mouse peritoneal macrophages induced by sodium aurothiomalate. Proc Univ Otago Med School 56:17–19

    Google Scholar 

  32. Van Furth R, Zanvil AC (1970) The origin and kinetics of mononuclear phagocytes. Semin Hematol 7:125–141

    Google Scholar 

  33. Van Furth R, Diesselhoff-den Dulk MMC, Raeburn JA, Zwet TL, Crofton R, Albas O (1980) Characteristics, origin and kinetics of human and murine mononuclear phagocytes. In: Van Furth R (ed) Mononuclear phagocytes. Nijhoff, The Hague

    Google Scholar 

  34. Beelen RHJ, Broekhuis-Fluitsma DM, Kom C, Hoefsmit ECM (1978) Identification of exudate-resident macrophages on the basis of peroxidatic activity. J Reticulo Endothel 23:103–109

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Adelaide, Adelaide, South Australia

    D. R. Haynes & B. Vernon-Roberts

  2. Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia

    I. R. Garrett & B. Vernon-Roberts

Authors
  1. D. R. Haynes
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  2. I. R. Garrett
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  3. B. Vernon-Roberts
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Haynes, D.R., Garrett, I.R. & Vernon-Roberts, B. Effect of gold salt treatment on the receptor binding activity of monocytes and macrophages isolated from rats with adjuvant arthritis. Rheumatol Int 8, 159–164 (1988). https://doi.org/10.1007/BF00270454

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  • DOI: https://doi.org/10.1007/BF00270454

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