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Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants

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Abstract

The N-oxides of pyrrolizidine alkaloids such as senecionine or monocrotaline are rapidly taken up and accumulated by cell suspension cultures obtained from plants known to produce pyrrolizidines, i.e. Senecio vernalis, vulgaris, viscosus (Asteraceae) and Symphytum officinale (Boraginaceae). The transport of the N-oxides into the cells is a specific and selective process. Other alkaloid N-oxides such as sparteine N-oxide are not taken up. Cell cultures from plant species which do not synthesize pyrrolizidine alkaloids are unable to accumulate pyrrolizidine N-oxides. The suitability of the pyrrolizidine N-oxides in alkaloid storage and accumulation is emphasized.

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References

  • Boppré M (1985) Naturwissenschaften (in press).

  • Craig JC, Purushothaman KK (1970) J. Org. Chem. 35: 1721–1722.

    Google Scholar 

  • Deus-Neumann B, Zenk MH (1984) Planta 162: 250–260

    Google Scholar 

  • Hartmann T, Zimmer M (1986) J. Plant Physiol. 122: 67–80

    Google Scholar 

  • Matile P (1978) Ann. Rev. Plant Physiol. 29: 193–213.

    Google Scholar 

  • Neumann D, Krauss G, Hieke M, Groeger D (1983) Planta Medica 48: 20–23.

    Google Scholar 

  • Phillipson JD (1971) Xenobiotica 1: 419–447.

    Google Scholar 

  • Phillipson JD, Handa SS (1978) J. Nat. Prod. 41: 385–431.

    Google Scholar 

  • Renaudin JP, Guern J (1982) Physiol. Vegetale 20: 533–548.

    Google Scholar 

  • Rodriguez E, Levin DA (1976) In: Wallace JW, Mansell RL (eds) Rec. Adv. Phytochem. 10: 214–270 Plenum, New York.

    Google Scholar 

  • Wink M (1985) Naturwissenschaften 71: 635–636.

    Google Scholar 

  • Wink M, Witte L, Schiebel HM, Hartmann T (1980) Planta Medica 38: 238–245.

    Google Scholar 

  • Zenk MH, Rueffer M, Amann M, Deus-Neumann B (1985) J. Nat. Prod. 48: 725–738.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Institut für Pharmazeutische Biologie, Technische Universität Braunschweig, Mendelssohnstr. 1, D-3300, Braunschweig, Germany

    Kirsten von Borstel & Thomas Hartmann

Authors
  1. Kirsten von Borstel
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  2. Thomas Hartmann
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Communicated by M. H. Zenk

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von Borstel, K., Hartmann, T. Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants. Plant Cell Reports 5, 39–42 (1986). https://doi.org/10.1007/BF00269714

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  • DOI: https://doi.org/10.1007/BF00269714

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