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Enzymic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L. cell suspension cultures

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Abstract

o-Succinylbenzoic acid (OSB) is an intermediate in the biosynthesis of shikimatederived anthraquinones. The cell free activation of o-succinylbenzoic acid in extracts of anthraquinone producing cells of Galium mollugo L. is demonstrated for the first time. This activation depends on the presence of ATP, coenzyme A and Mg2+. The o-succinylbenzoic acid coenzyme A ester was identified by converting it to 1,4-dihydroxy-2-naphthoic acid by a bacterial enzyme, viz. naphthoatesynthase. It is thus demonstrated that the o-succinylbenzoic acid coenzyme A ester derived from bacteria and from Galium mollugo cells are identical.

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Authors and Affiliations

  1. Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität, Hittorfstraße 56, D-4400, Münster, F.R.G.

    Lutz Heide, Rainer Kolkmann, Sibylle Arendt & Eckhard Leistner

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  1. Lutz Heide
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  2. Rainer Kolkmann
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  3. Sibylle Arendt
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  4. Eckhard Leistner
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Heide, L., Kolkmann, R., Arendt, S. et al. Enzymic synthesis of o-succinylbenzoyl-CoA in cell-free extracts of anthraquinone producing Galium mollugo L. cell suspension cultures. Plant Cell Reports 1, 180–182 (1982). https://doi.org/10.1007/BF00269193

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  • DOI: https://doi.org/10.1007/BF00269193

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