Summary
The study of the high reversion frequency of the nic-2 mutant of Coprinus radiatus has been carried out with the help of homothallic strains and by selecting for diploïds. Homothallic strains revert at meïosis with the usual frequency of about 20%; this is definitely in favor of the high reversion frequency being an intrinsic property of the mutation. Diploid nic-2 strains also exhibit the usual reversion frequency at meiosis but no more than haploïd strains or dicaryotes do, they do not revert during vegetative growth. The reversion is therefore not directly correlated with the diploïd state. The possible nature of the nic-2 mutation and how its reversion could occur are discussed.
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Bibliographie
Atwood, K. C.: Some aspects of the bobbed problem in Drosophila. Genetics 61, 319–328 (1969).
Bausum, H. T., Wagner, R. P.: “Selfing” and other form of aberrant recombination in isoleucine-valine mutants of Neurospora. Genetics 51, 815–830 (1965).
Benziger, R., Hartmann, P. E.: Effects of U. V. light on transducing phage P22. Virology 18, 614–628 (1962).
Boncinelli, E., Graziani, F., Polito, L., Malva, C. Ritossa, F.: rDNA magnification at the bobbed locus of the Y chromosome of Drosophila melanogaster. J. Cell Diff. (sous presse). (1972).
Brygoo, Y.: Comm. pers.
Callan, H. G.: On the organisation of genetics units in chromosomes. J. Cell Sci. 2, 1–7 (1967).
Clark, A. J.: Recurrent nucleotide sequences as explanation of the Selfing phenomenon in Salmonella typhimurium. Z. Vererbungsl. 95, 368–373 (1964).
Dawson, G. W. P., Smith Keary, P. F.: Episomic control of mutation in Salmonella thyphimurium. Heredity 18, 1–20 (1963).
Demerec, M.: Selfer mutants of Salmonella typhimurium. Genetics 48, 1519–1531 (1963).
Fincham, J. R. S.: Mutable genes in the light of callan's hypothesis of serially repeated gene copies. Nature (Lond.) 215, 864–866 (1967).
Fox, A. S., Yoon, S. B.: DNA induced transformation in Drosophila: locus specificity and the establishement of transformed stocks. Proc. nat. Acad. Sci. (Wash.) 67, 1608–1615 (1970).
Gall, J. G.: The genes for ribosomal RNA during oogenesis. Genetics, Suppl. 121–132 (1969).
Gans, M., Masson, M.: Structure fine du locure ur-1 chez Coprinus radiatus. Molec. gen. Genet. 105, 164–181 (1969).
Grell, R.: Meiotic and somatic pairing dans “Genetic Organisation” Caspari C. (1970).
Green, M. M.: The genetics of a mutable gene at the white locus of D. melanogaster. Genetics 56, 467–482 (1967).
Green, M. M.: Some genetic properties of intrachromosomal recombination. Molec. gen. Genet. 103, 209–217 (1968).
Guerdoux, J. L.: Réversion à haute fréquence d'un gène nicotinique moins chez le Coprinus radiatus. Molec. gen. Genet. 105, 334–343 (1969).
Guerdoux, J. L.: Modifications de la haute fréquence de réversion du mutant nic-2. Molec. gen. Genet. 110, 307–326 (1971).
Imada, M., Inouye, M., Eda, M., Tsugita, A.: Frameshift mutation in the lysozyme gene of bacteriophage T 4: demonstration of the insertion of four bases and the preferential occurence of base addition in Acridine mutagenesis. J. molec. Biol. 54, 199–217 (1970).
Jordan, E.: 0° and strong polar mutations in the gal operon are insertions. Molec. gen. Genet. 102, 353–363 (1968).
Lewis, D.: Genetic analysis of methionine suppressor in Coprinus. Genet. Res. 2, 141–155 (1961)
McClintock, B.: Controlling elements and the gene. Cold Spr. Harb. Symp. quant. Biol. 21, 197–216 (1956).
Morgan, D. H.: Suppression of purple in Coprinus lagopus: an anomalous genetic situation. Genet. Res. 7, 195–206 (1966).
Motta, R.: Comm. Pers.
Ocada, Y., Amagase, S., Tsugita, A.: Framshift mutation in the lysozyme gene of bacteriophage T 4: demonstration of the insertion of gene bases, and a summary of in vivo codons and lysozyme activities. J. molec. Biol. 54, 219–246 (1970).
Peterson, P. A.: Controlling elements and mutable loci in maize: their relationship to bacterial episomes. Genetica 41, 33–56 (1970).
Prevost, G.: Etude génétique d'un basidiomycète: «Coprinus radiatus» Fr. ex. Bolt. Thèse Paris (1962).
Prud'Homme, N.: Recombinaisons mitotiques chez un basidiomycète Coprinus radiatus. Molec. gen. Genet. 107, 256–271 (1970).
Ritossa, F. M.: Unstable redundancy of genes for ribosomal DNA. Proc. nat. Acad. Sci. (Wash.) 60, 509–516 (1968).
Shapiro, J. A.: Mutations caused by the insertion of genetic material into the galactose operon of Escherichia coli. J. molec. Biol. 40, 93–105 (1969).
Streisinger, G., Ocada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., Inouye, M.: Frameshift mutations and the genetic code. Cold Spri. Harb. Symp. quant. Biol. 31, 77–84 (1966).
Sturtevant, A. M.: A further study of the so-called mutation at the Bar locus of Drosophila. Genetics 12, 401 (1927).
Thomas, C. A., Jr.: Recombination of DNA molecules. Dans “Progress in nuclei acid research and molecular biology” Davidson et Cohn éditeurs.
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Guerdoux, J.L. Transformations spontanées du mutant nicotinique deux du Coprinus radiatus: Etude de souches nic-2 homothalliques ou diploides. Molec. Gen. Genet. 119, 119–129 (1972). https://doi.org/10.1007/BF00269131
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DOI: https://doi.org/10.1007/BF00269131