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Transposition of ampicillin resistance from RP4 to other replicons

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Summary

The ampicillin resistance (β-lactamase) determinant of RP4 can be transposed onto various other replicons genetically unrelated to RP4 including several but not all R factors.

Plasmids which acquire this resistance show an increase in molecular weight. They also acquire the ability to transpose the ampicillin resistance to further replicons.

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Authors and Affiliations

  1. Bacteriology Department, Royal Postgraduate Medical School, London

    R. W. Hedges & A. E. Jacob

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  1. R. W. Hedges
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  2. A. E. Jacob
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Communicated by W. Maas

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Hedges, R.W., Jacob, A.E. Transposition of ampicillin resistance from RP4 to other replicons. Molec. Gen. Genet. 132, 31–40 (1974). https://doi.org/10.1007/BF00268228

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  • DOI: https://doi.org/10.1007/BF00268228

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