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Pharmacokinetics of intravenous bisoprolol in obese and non-obese volunteers

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Summary

The pharmacokinetics of a single i. v. dose of dlbisoprolol 0.16 mg·kg−1 ideal body weight has been studied in 8 obese women (mean weight 91 kg; 161% of ideal body weight) and 8 non-obese women (51 kg; 94% of ideal body weight).

Compared to the controls, the obese subjects showed an increase in the total apparent volume of distribution (Vz) (182 vs 135 1) and a decrease in Vz per kg body weight (2 vs 2.7 l·kg−1). There was a negative correlation between Vz l·kg−1 and the percentage of ideal body weight (r=−0.672). Total body clearance was increased, but t1/2 and renal clearance was unchanged.

It is concluded that tissue diffusion of bisoprolol in obese subjects is limited, despite its lipophilicity, possibly because of alteration in the blood flow to adipose tissue produced by bisoprolol.

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Authors and Affiliations

  1. Service de Médecine Interne, Hôpital Laennec, Paris, France

    C. Le Jeunne & F. C. Hugues

  2. Service de Pharmacologie, Hôpital Saint-Antoine, Paris, France

    J. M. Poirier, G. Cheymol & F. Engel

  3. Laboratoires Lederlé, Paris, France

    O. Ertzbischoff

Authors
  1. C. Le Jeunne
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  2. J. M. Poirier
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  3. G. Cheymol
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  4. O. Ertzbischoff
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  5. F. Engel
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  6. F. C. Hugues
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Le Jeunne, C., Poirier, J.M., Cheymol, G. et al. Pharmacokinetics of intravenous bisoprolol in obese and non-obese volunteers. Eur J Clin Pharmacol 41, 171–174 (1991). https://doi.org/10.1007/BF00265912

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  • DOI: https://doi.org/10.1007/BF00265912

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