Summary
The predictive accuracy of the Cockroft and Gault equation in the assessment of creatinine clearance was evaluated in 30 Nigerian patients with hypertension, congestive heart failure, chronic renal failure and varying degrees of renal impairment.
There was a high correlation between the measured and predicted creatinine clearance as shown by the regression equation: measured creatinine clearance = 0.84 predicted creatinine clearance +4.5 ml·min−1 (r 2=0.74). The prediction error, reflecting the disparity between measured and calculated clearance was low at 2.0 (15.4) ml·min−1.
Neither sex nor disease state or level of creatinine concentration had an important effect on the predictive value of the equation in Nigerians.
References
Cockroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16: 31–41
Hull JH, Hak LJ, Kock GG, Wargin WA, Chi SL, Mattocks AM (1981) Influence of range of renal function and liver disease on predictability of creatinine clearance. Clin Pharmacol Ther 29: 516–521
Jellife RW (1973) Creatinine clearance: Bedside estimate. Ann Intern Med 79: 604–605
Mawer EG, Knowles BR, Lucas SB, Stirland RM, Tooth JA (1972) Computer assisted prescribing of Kanamycin for patients with renal insufficiency. Lancet I: 12–15
Robert Shaw M, Lai KN, Swaminathan R (1989) Prediction of creatinine clearance from plasma creatinine: Comparison of five formulae. Br J Clin Pharmacol 28: 275–280
Durakovic Z (1986) Creatinine clearance in the elderly: A comparison of direct measurement and calculation from serum creatinine. Nephron 44: 66–69
Salazar DE, Corcoran GB (1988) Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat free body mass. Am J Med 84: 1053–1060
Gates GF (1985) Creatinine clearance estimation from serum creatinine values: An analysis of three mathematical modes of Glomerular filtration. Am J Kid Dis S 5: 199–205
Payne RB (1986) Creatinine clearance: a redundant clinical investigation. Ann Clin Biochem 23: 243–250
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Ajayi, A.A. Estimation of creatinine clearance from serum creatinine: utility of the cockroft and gault equation in Nigerian patients. Eur J Clin Pharmacol 40, 429–431 (1991). https://doi.org/10.1007/BF00265859
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DOI: https://doi.org/10.1007/BF00265859