Summary
The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l·h−1.
In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bowery NG, Hill DR, Hudson AL, Doble A, Middlemiss DN, Shaw JS, Turnbull M (1980) Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283: 92–94
Bowery NG, Doble A, Hill DR, Hudson AL, Shaw JS, Turnbull MJ, Warrington R (1981) Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals. Eur J Pharmacol 71: 53–70
Bowery NG, Hill DR, Hudson AL (1983) Characteristics of GABA-B receptor binding sites on rat whole brain synaptic membranes. Br J Pharmacol 78: 191–206
Price GW, Wilkin GP, Turnbull MJ, Bowery NG (1984) Are baclofen sensitive GABA-B receptors present on primary afferent terminals of the spinal cord. Nature 307: 71–74
Knutsson E, Lindblom U, Martensson A (1974) Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis. J Neurol Sci 23: 473–484
Penn RD, Kroin JS (1983) Intrathecal baclofen alleviates spinal cord spasticity. Lancet I: 116–121
Sallerin-Caute B, Monsarrat B, Lazorthes Y, Cross J, Bastide R (1988) A sensitive method for the determination of baclofen in human CSF by high performance liquid chormatography. J Liq Chromatogr 11 (8): 1753–1761
Lazorthes Y, Sallerin-Caute B, Verdie JC, Bastide R, Carillo JP (1990) Chronic intrathecal baclofen administration for control of severe spasticity. J Neurosurg 72: 393–402
Penn RD, Kroin JS (1987) Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 66: 181–185
Faigle JW, Keberle H (1972) The chemistry and kinetics of Lioresal. Postgrad Med J 48 [Suppl]: 9–13
Faigle JW, Keberle H, Degen PH (1980) Chemistry and pharmacokinetics of baclofen. In: Feldman RG, Young RR, Koalla WP (eds) Spasticity: disordered motor control. Year Book, Chicago, 461–475
Ahuja S (1985) Baclofen. Analyt Profiles Drug Subst 14: 527–548
Wuis EW, Dirks RJM, Vree TB, Van Der Kleyn E (1985) High-performance liquid chromatographic analysis of baclofen in plasma and urine of man after precolumn extraction and derivatization with O-phtadialdehyde. J Chromatogr 337: 341–350
Muller H, Zierski J, Dralle D, Kraub D, Mart-Schler E (1988) Pharmacokinetics of intrathecal baclofen. In: Muller H, Zierski J, Penn R (eds) Local spinal therapy of spasticity. Springer, Berlin Heidelberg New York, pp 155–214
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sallerin-Caute, B., Lazorthes, Y., Monsarrat, B. et al. CSF Baclofen levels after intrathecal administration in severe spasticity. Eur J Clin Pharmacol 40, 363–365 (1991). https://doi.org/10.1007/BF00265844
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00265844